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• W2972498170 abstract "MHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified a regulatory role of MHC I in TLR signaling and antibacterial immunity. However, its role in innate antiviral immunity remains unknown. In this study, we found a reduced viral load in MHC I-deficient macrophages that was independent of type I IFN production. Mechanically, MHC I mediated viral suppression by inhibiting the type I IFN signaling pathway, which depends on SHP2. Cross-linking MHC I at the membrane increased SHP2 activation and further suppressed STAT1 phosphorylation. Therefore, our data revealed an inhibitory role of MHC I in type I IFN response to viral infection and expanded our understanding of MHC I and antigen presentation." @default.
• W2972498170 created "2019-09-19" @default.
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• W2972498170 date "2019-09-09" @default.
• W2972498170 modified "2023-10-15" @default.
• W2972498170 title "MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling" @default.
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• W2972498170 doi "https://doi.org/10.1155/2019/5370706" @default.
• W2972498170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6754968" @default.
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