FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972521565> ?p ?o ?g. }

• W2972521565 endingPage "E205" @default.
• W2972521565 startingPage "E204" @default.
• W2972521565 abstract "Radiation (RT)-induced lymphopenia (RIL) is associated with worse survival in patients with solid tumors. Here, it was hypothesized that spleen dosimetry parameters would correlate with lymphocyte loss rate during RT and total % lymphocyte loss. This registry-based study included 211 patients who received conventionally fractionated RT for pancreaticobiliary (PB, n = 86) or gastroesophageal (GE, n = 65) tumors and stereotactic body RT (SBRT, n = 56) for hepatic tumors who had spleen dose volume histograms (DVHs) available. Area under each DVH (AUC) was approximated using the trapezoidal rule. Loss rates were determined through a previously described method where the initial 3 weeks of treatment are fit to an exponential decay in the form ALC(x) = ae-bx and the percent per fraction lymphocyte loss (FLL) was calculated as FLL = (1 – e-b)*100. Intergroup comparisons between PB and GE patients were done with the Mann-Whitney U Test. For each treatment site, spleen volumes receiving anywhere from 2 Gy (V2) to 25 Gy (V25), mean spleen dose, and AUC were correlated with FLL and the total % loss in absolute lymphocyte count (ALC) throughout treatment using simple linear regression. Multiple variable regression was then used to control for planning treatment volume (PTV) for each parameter. Median FLL (9.5, 12.5), % ALC loss (80.0, 88.9), mean spleen dose (7.8, 17.1), V15 (45.3, 114.6), and AUC (2448.7, 3913.9) were all lower for PB patients as compared to GE patients (all p < 0.001). PB and SBRT patients had no correlations between any volume from V2–V25, mean spleen dose, and AUC with FLL or % ALC loss. For GE patients, volumes from V3-V25 (highest at V15, R = 0.363, p = 0.008), mean spleen dose (R = 0.353, p = 0.008), and AUC (R = 0.340, p = 0.011) all correlated with FLL. Similar statistically significant correlations were seen for those parameters with % ALC loss. After controlling for PTV, V15 (p = 0.019) held a significant correlation with FLL, though mean spleen dose (p = 0.055) and AUC (p = 0.059) were borderline insignificant. V15 (p = 0.038), mean spleen dose (p = 0.043), and AUC (p = 0.038) were each significantly correlated with % ALC loss after controlling for PTV. PB and SBRT patients showed no relationship between spleen dosimetry parameters and lymphocyte loss rate or % ALC loss through treatment. Given the relatively small dose delivered to the spleen, these results suggest that ALC loss in these patients is driven primarily by other parameters. In contrast, GE patients showed strong correlations of spleen dosimetry parameters with lymphocyte loss rates and % ALC loss." @default.
• W2972521565 created "2019-09-19" @default.
• W2972521565 creator A5023651604 @default.
• W2972521565 creator A5025641478 @default.
• W2972521565 creator A5072194902 @default.
• W2972521565 creator A5091243183 @default.
• W2972521565 date "2019-09-01" @default.
• W2972521565 modified "2023-09-26" @default.
• W2972521565 title "Relationship Between Spleen Dosimetry Parameters and Lymphocyte Loss in Patients with Abdominal Tumors" @default.
• W2972521565 doi "https://doi.org/10.1016/j.ijrobp.2019.06.2037" @default.
• W2972521565 hasPublicationYear "2019" @default.
• W2972521565 type Work @default.
• W2972521565 sameAs 2972521565 @default.
• W2972521565 citedByCount "0" @default.
• W2972521565 crossrefType "journal-article" @default.
• W2972521565 hasAuthorship W2972521565A5023651604 @default.
• W2972521565 hasAuthorship W2972521565A5025641478 @default.
• W2972521565 hasAuthorship W2972521565A5072194902 @default.
• W2972521565 hasAuthorship W2972521565A5091243183 @default.
• W2972521565 hasConcept C126322002 @default.
• W2972521565 hasConcept C126894567 @default.
• W2972521565 hasConcept C2777761686 @default.
• W2972521565 hasConcept C2780931953 @default.
• W2972521565 hasConcept C2989005 @default.
• W2972521565 hasConcept C71924100 @default.
• W2972521565 hasConcept C75088862 @default.
• W2972521565 hasConcept C90924648 @default.
• W2972521565 hasConceptScore W2972521565C126322002 @default.
• W2972521565 hasConceptScore W2972521565C126894567 @default.
• W2972521565 hasConceptScore W2972521565C2777761686 @default.
• W2972521565 hasConceptScore W2972521565C2780931953 @default.
• W2972521565 hasConceptScore W2972521565C2989005 @default.
• W2972521565 hasConceptScore W2972521565C71924100 @default.
• W2972521565 hasConceptScore W2972521565C75088862 @default.
• W2972521565 hasConceptScore W2972521565C90924648 @default.
• W2972521565 hasIssue "1" @default.
• W2972521565 hasLocation W29725215651 @default.
• W2972521565 hasOpenAccess W2972521565 @default.
• W2972521565 hasPrimaryLocation W29725215651 @default.
• W2972521565 hasRelatedWork W1629649714 @default.
• W2972521565 hasRelatedWork W1991176685 @default.
• W2972521565 hasRelatedWork W2057536270 @default.
• W2972521565 hasRelatedWork W2148656812 @default.
• W2972521565 hasRelatedWork W2349150299 @default.
• W2972521565 hasRelatedWork W2353767080 @default.
• W2972521565 hasRelatedWork W2392413698 @default.
• W2972521565 hasRelatedWork W2512421757 @default.
• W2972521565 hasRelatedWork W45329928 @default.
• W2972521565 hasRelatedWork W2118673085 @default.
• W2972521565 hasVolume "105" @default.
• W2972521565 isParatext "false" @default.
• W2972521565 isRetracted "false" @default.
• W2972521565 magId "2972521565" @default.
• W2972521565 workType "article" @default.