Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972536090> ?p ?o ?g. }
- W2972536090 endingPage "144" @default.
- W2972536090 startingPage "126" @default.
- W2972536090 abstract "ABSTRACT Human skin wound repair may result in various outcomes with most of them leading to scar formation. Commonly seen in many cutaneous wound healing cases, hypertrophic scars are considered as phenotypes of abnormal wound repair. To prevent the formation of hypertrophic scars, efforts have been made to understand the mechanism of scarring following wound closure. Numerous in vivo and in vitro models have been created to facilitate investigations into cutaneous scarring and the development of antiscarring treatments. To select the best model for a specific study, background knowledge of the current models of hypertrophic scars is necessary. In this review, we describe in vivo and in vitro models for studying hypertrophic scars, as well as the distinct characteristics of these models. The choice of models for a specific study should be based on the characteristics of the model and the goal of the study. In general, in vivo animal models are often used in phenotypical scar formation analysis, development of antiscarring treatment, and functional analyses of individual genes. In contrast, in vitro models are chosen to pathway identification during scar formation as well as in high‐throughput analysis in drug development. Besides helping investigators choose the best scarring model for their research, the goal of this review is to provide knowledge for improving the existing models and development of new models. These will contribute to the progress of scarring studies." @default.
- W2972536090 created "2019-09-19" @default.
- W2972536090 creator A5012922632 @default.
- W2972536090 creator A5039078294 @default.
- W2972536090 creator A5052947572 @default.
- W2972536090 creator A5059729439 @default.
- W2972536090 creator A5081564639 @default.
- W2972536090 creator A5086249677 @default.
- W2972536090 creator A5086862928 @default.
- W2972536090 date "2019-10-21" @default.
- W2972536090 modified "2023-10-10" @default.
- W2972536090 title "Experimental models for cutaneous hypertrophic scar research" @default.
- W2972536090 cites W1499425017 @default.
- W2972536090 cites W1523516129 @default.
- W2972536090 cites W1582568528 @default.
- W2972536090 cites W1603490962 @default.
- W2972536090 cites W1660648079 @default.
- W2972536090 cites W1895645464 @default.
- W2972536090 cites W1924256936 @default.
- W2972536090 cites W1958710513 @default.
- W2972536090 cites W1963867132 @default.
- W2972536090 cites W1964770310 @default.
- W2972536090 cites W1966739314 @default.
- W2972536090 cites W1968054341 @default.
- W2972536090 cites W1969613624 @default.
- W2972536090 cites W1969703263 @default.
- W2972536090 cites W1971460749 @default.
- W2972536090 cites W1973733466 @default.
- W2972536090 cites W1975411426 @default.
- W2972536090 cites W1976252450 @default.
- W2972536090 cites W1979581862 @default.
- W2972536090 cites W1982284613 @default.
- W2972536090 cites W1984777209 @default.
- W2972536090 cites W1985171009 @default.
- W2972536090 cites W1986853633 @default.
- W2972536090 cites W1988264024 @default.
- W2972536090 cites W1988871156 @default.
- W2972536090 cites W1989250954 @default.
- W2972536090 cites W1990932797 @default.
- W2972536090 cites W1992089021 @default.
- W2972536090 cites W1995456591 @default.
- W2972536090 cites W1996131014 @default.
- W2972536090 cites W1999852483 @default.
- W2972536090 cites W2000865288 @default.
- W2972536090 cites W2001524594 @default.
- W2972536090 cites W2001731847 @default.
- W2972536090 cites W2006175469 @default.
- W2972536090 cites W2006533920 @default.
- W2972536090 cites W2009109939 @default.
- W2972536090 cites W2009721592 @default.
- W2972536090 cites W2010649547 @default.
- W2972536090 cites W2010798028 @default.
- W2972536090 cites W2012072987 @default.
- W2972536090 cites W2015551486 @default.
- W2972536090 cites W2019054421 @default.
- W2972536090 cites W2020149007 @default.
- W2972536090 cites W2020427308 @default.
- W2972536090 cites W2025780832 @default.
- W2972536090 cites W2026129217 @default.
- W2972536090 cites W2028260435 @default.
- W2972536090 cites W2029858303 @default.
- W2972536090 cites W2032013289 @default.
- W2972536090 cites W2033859027 @default.
- W2972536090 cites W2035243135 @default.
- W2972536090 cites W2038242891 @default.
- W2972536090 cites W2038812640 @default.
- W2972536090 cites W2039295429 @default.
- W2972536090 cites W2042754317 @default.
- W2972536090 cites W2043900785 @default.
- W2972536090 cites W2047803542 @default.
- W2972536090 cites W2050252268 @default.
- W2972536090 cites W2051247089 @default.
- W2972536090 cites W2051803926 @default.
- W2972536090 cites W2053688285 @default.
- W2972536090 cites W2054091637 @default.
- W2972536090 cites W2054560451 @default.
- W2972536090 cites W2056072605 @default.
- W2972536090 cites W2056892942 @default.
- W2972536090 cites W2057634651 @default.
- W2972536090 cites W2058882213 @default.
- W2972536090 cites W2060715443 @default.
- W2972536090 cites W2062252963 @default.
- W2972536090 cites W2064405864 @default.
- W2972536090 cites W2064761422 @default.
- W2972536090 cites W2067479803 @default.
- W2972536090 cites W2071463380 @default.
- W2972536090 cites W2073028076 @default.
- W2972536090 cites W2074149819 @default.
- W2972536090 cites W2077081478 @default.
- W2972536090 cites W2077446787 @default.
- W2972536090 cites W2078480708 @default.
- W2972536090 cites W2079292560 @default.
- W2972536090 cites W2080318490 @default.
- W2972536090 cites W2083509286 @default.
- W2972536090 cites W2087194472 @default.
- W2972536090 cites W2090221057 @default.
- W2972536090 cites W2091282532 @default.
- W2972536090 cites W2092889585 @default.