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• W2972606485 startingPage "2619" @default.
• W2972606485 abstract "Abstract Megakaryopoiesis is the process of formation of mature megakaryocytes that takes place in the bone marrow niche resulting in the release of platelets into the peripheral blood. It has been suggested that cell to cell communication in this dense bone marrow niche may influence the fate of the cells. Numerous studies point to the role of exosomes and microvesicles not only as a messenger of the cellular crosstalk but also in growth and developmental process of various cell types. In the current study, we explored the effects of megakaryocyte‐derived microvesicles in hematopoietic cell lines in the context of differentiation. Our study demonstrated that microvesicles isolated from the induced megakaryocytic cell lines have the ability to stimulate noninduced cells specifically into that particular lineage. We showed that this lineage commencement comes from the change in the methylation status of Notch1 promoter, which is regulated by DNA methyltransferases." @default.
• W2972606485 created "2019-09-19" @default.
• W2972606485 creator A5004376410 @default.
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• W2972606485 date "2019-09-09" @default.
• W2972606485 modified "2023-10-14" @default.
• W2972606485 title "Microvesicles promote megakaryopoiesis by regulating DNA methyltransferase and methylation of Notch1 promoter" @default.
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• W2972606485 doi "https://doi.org/10.1002/jcp.29166" @default.
• W2972606485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31502256" @default.
• W2972606485 hasPublicationYear "2019" @default.
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