Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972607617> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2972607617 endingPage "74" @default.
- W2972607617 startingPage "69" @default.
- W2972607617 abstract "Prolyl endopeptidase is involved in neurodegeneration, proliferation, neuroinflammation, and neuron differentiation. It has been observed that severity of the neurodegenerative process correlates with an increasing level of prolyl endopeptidase in the brain. According to recent research, prolyl endopeptidase might interact with prion-like proteins, which are believed to play the key role in the development of neurodegenerative diseases. Consequently, prolyl endopeptidase inhibitors might be a promising group of chemicals to study in neurodegenerative diseases, particularly Parkinson’s disease. The aim of this research was to determine the effects of benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, a new inhibitor of prolyl endopeptidase, using haloperidol catalepsy test in SHK outbred mice and Parkinson-like syndrome induced by a single systemic injection of neurotoxic 1-methyl-4-phenyl-tetrahydropiridine at a dose of 30 mg/kg in C57Bl/6 inbred mice. As a result, the compound reduces the severity of the main extrapyramidal symptoms: rigidity and motor deficits. However, anticataleptic activity was not found. According to our results, the prolyl endopeptidase inhibitor does not affect the dopaminergic neurons directly but provides possible neuroprotection to the neurons." @default.
- W2972607617 created "2019-09-19" @default.
- W2972607617 creator A5039642895 @default.
- W2972607617 creator A5056156940 @default.
- W2972607617 creator A5065152731 @default.
- W2972607617 creator A5066360697 @default.
- W2972607617 date "2019-04-01" @default.
- W2972607617 modified "2023-10-13" @default.
- W2972607617 title "Antiparkinsonian Action of the Prolyl Endopeptidase Inhibitor in Mice" @default.
- W2972607617 cites W1487661483 @default.
- W2972607617 cites W1958274942 @default.
- W2972607617 cites W1979591162 @default.
- W2972607617 cites W1989984498 @default.
- W2972607617 cites W1999123976 @default.
- W2972607617 cites W2012933599 @default.
- W2972607617 cites W2028315913 @default.
- W2972607617 cites W2058698021 @default.
- W2972607617 cites W2112399469 @default.
- W2972607617 cites W2121065389 @default.
- W2972607617 cites W2288087911 @default.
- W2972607617 cites W2546550351 @default.
- W2972607617 cites W2605252223 @default.
- W2972607617 cites W2633685052 @default.
- W2972607617 cites W2871293796 @default.
- W2972607617 doi "https://doi.org/10.3103/s0096392519020044" @default.
- W2972607617 hasPublicationYear "2019" @default.
- W2972607617 type Work @default.
- W2972607617 sameAs 2972607617 @default.
- W2972607617 citedByCount "5" @default.
- W2972607617 countsByYear W29726076172020 @default.
- W2972607617 countsByYear W29726076172021 @default.
- W2972607617 countsByYear W29726076172022 @default.
- W2972607617 crossrefType "journal-article" @default.
- W2972607617 hasAuthorship W2972607617A5039642895 @default.
- W2972607617 hasAuthorship W2972607617A5056156940 @default.
- W2972607617 hasAuthorship W2972607617A5065152731 @default.
- W2972607617 hasAuthorship W2972607617A5066360697 @default.
- W2972607617 hasBestOaLocation W29726076172 @default.
- W2972607617 hasConcept C104826730 @default.
- W2972607617 hasConcept C126322002 @default.
- W2972607617 hasConcept C137183658 @default.
- W2972607617 hasConcept C15744967 @default.
- W2972607617 hasConcept C169760540 @default.
- W2972607617 hasConcept C181199279 @default.
- W2972607617 hasConcept C185592680 @default.
- W2972607617 hasConcept C25498285 @default.
- W2972607617 hasConcept C2776775109 @default.
- W2972607617 hasConcept C2776925932 @default.
- W2972607617 hasConcept C2779134260 @default.
- W2972607617 hasConcept C2779734285 @default.
- W2972607617 hasConcept C2780476085 @default.
- W2972607617 hasConcept C2780948584 @default.
- W2972607617 hasConcept C513476851 @default.
- W2972607617 hasConcept C55493867 @default.
- W2972607617 hasConcept C71924100 @default.
- W2972607617 hasConcept C87753298 @default.
- W2972607617 hasConcept C98274493 @default.
- W2972607617 hasConceptScore W2972607617C104826730 @default.
- W2972607617 hasConceptScore W2972607617C126322002 @default.
- W2972607617 hasConceptScore W2972607617C137183658 @default.
- W2972607617 hasConceptScore W2972607617C15744967 @default.
- W2972607617 hasConceptScore W2972607617C169760540 @default.
- W2972607617 hasConceptScore W2972607617C181199279 @default.
- W2972607617 hasConceptScore W2972607617C185592680 @default.
- W2972607617 hasConceptScore W2972607617C25498285 @default.
- W2972607617 hasConceptScore W2972607617C2776775109 @default.
- W2972607617 hasConceptScore W2972607617C2776925932 @default.
- W2972607617 hasConceptScore W2972607617C2779134260 @default.
- W2972607617 hasConceptScore W2972607617C2779734285 @default.
- W2972607617 hasConceptScore W2972607617C2780476085 @default.
- W2972607617 hasConceptScore W2972607617C2780948584 @default.
- W2972607617 hasConceptScore W2972607617C513476851 @default.
- W2972607617 hasConceptScore W2972607617C55493867 @default.
- W2972607617 hasConceptScore W2972607617C71924100 @default.
- W2972607617 hasConceptScore W2972607617C87753298 @default.
- W2972607617 hasConceptScore W2972607617C98274493 @default.
- W2972607617 hasIssue "2" @default.
- W2972607617 hasLocation W29726076171 @default.
- W2972607617 hasLocation W29726076172 @default.
- W2972607617 hasOpenAccess W2972607617 @default.
- W2972607617 hasPrimaryLocation W29726076171 @default.
- W2972607617 hasRelatedWork W2024094300 @default.
- W2972607617 hasRelatedWork W2028586227 @default.
- W2972607617 hasRelatedWork W2168941505 @default.
- W2972607617 hasRelatedWork W2170532269 @default.
- W2972607617 hasRelatedWork W2194824303 @default.
- W2972607617 hasRelatedWork W2531113777 @default.
- W2972607617 hasRelatedWork W2574513759 @default.
- W2972607617 hasRelatedWork W2763534419 @default.
- W2972607617 hasRelatedWork W2996807866 @default.
- W2972607617 hasRelatedWork W3154300785 @default.
- W2972607617 hasVolume "74" @default.
- W2972607617 isParatext "false" @default.
- W2972607617 isRetracted "false" @default.
- W2972607617 magId "2972607617" @default.
- W2972607617 workType "article" @default.