FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972640888> ?p ?o ?g. }

• W2972640888 endingPage "711" @default.
• W2972640888 startingPage "711" @default.
• W2972640888 abstract "Background: Sometimes dental implants seem to be the only therapeutic alternative for the oral rehabilitation of patients with Down syndrome, given that they usually lose all their teeth early due to suffering aggressive periodontitis and they do not usually have the skills required to wear removable prostheses. However, the evolution of dental implants in these patients shows very adverse results. It is possible that basal genetic alterations, or at least some characteristics of these, may underlie these clinical results. The metabolic pathway of metallothioneins, molecules with an important influence on bone metabolism, could be one of the said alterations. Aims: To determine whether the expression of metallothioneins (MTs) and their metabolic pathway may be identified and related to the periodontitis and lack of osseointegration of dental implants in Down syndrome patients. Materials and Methods: Retrospective study of cases and controls by comparing patients with Down syndrome, periodontal disease, and implant failure (four patients, test group) with patients with Down syndrome, without periodontal disease, and without implant failure after two years of following (seven patients, control group), by extracting peripheral blood at the time of the dental examination to extract RNA and its subsequent processing in relation to gene expression of the metabolic pathway of metallothioneins. Results: The results identified low expression in the group of patients with periodontal disease and implant failure of genes MT1E, MT1H, MT1X, MT1A, MT1B, MT1C, MT1L, MT2A, MT1M, and MT1G. Conclusions: The low MT1 and MT2 gene expression seems to be related to the onset of periodontal disease and implant rejection in Down syndrome patients, although more data are required to confirm whether this relationship is due to one of the two conditions, to both independently, or to the two jointly—this last option being indicated by our current study." @default.
• W2972640888 created "2019-09-19" @default.
• W2972640888 creator A5002811242 @default.
• W2972640888 creator A5014398550 @default.
• W2972640888 creator A5041712262 @default.
• W2972640888 creator A5052978488 @default.
• W2972640888 creator A5054393881 @default.
• W2972640888 creator A5056913085 @default.
• W2972640888 creator A5065608841 @default.
• W2972640888 creator A5078011550 @default.
• W2972640888 date "2019-09-14" @default.
• W2972640888 modified "2023-10-18" @default.
• W2972640888 title "Metallothioneins in Failure of Dental Implants and Periodontitis Down Syndrome Patients" @default.
• W2972640888 cites W1759490374 @default.
• W2972640888 cites W2011242572 @default.
• W2972640888 cites W2041169931 @default.
• W2972640888 cites W2055778425 @default.
• W2972640888 cites W2065743337 @default.
• W2972640888 cites W2083662957 @default.
• W2972640888 cites W2098263816 @default.
• W2972640888 cites W2117908259 @default.
• W2972640888 cites W2124205377 @default.
• W2972640888 cites W2146140434 @default.
• W2972640888 cites W2155198112 @default.
• W2972640888 cites W2163970776 @default.
• W2972640888 cites W2164272347 @default.
• W2972640888 cites W2165172658 @default.
• W2972640888 cites W2274079794 @default.
• W2972640888 cites W2406020967 @default.
• W2972640888 cites W2531578787 @default.
• W2972640888 cites W2799274979 @default.
• W2972640888 doi "https://doi.org/10.3390/genes10090711" @default.
• W2972640888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6770985" @default.
• W2972640888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31540037" @default.
• W2972640888 hasPublicationYear "2019" @default.
• W2972640888 type Work @default.
• W2972640888 sameAs 2972640888 @default.
• W2972640888 citedByCount "9" @default.
• W2972640888 countsByYear W29726408882020 @default.
• W2972640888 countsByYear W29726408882021 @default.
• W2972640888 countsByYear W29726408882022 @default.
• W2972640888 countsByYear W29726408882023 @default.
• W2972640888 crossrefType "journal-article" @default.
• W2972640888 hasAuthorship W2972640888A5002811242 @default.
• W2972640888 hasAuthorship W2972640888A5014398550 @default.
• W2972640888 hasAuthorship W2972640888A5041712262 @default.
• W2972640888 hasAuthorship W2972640888A5052978488 @default.
• W2972640888 hasAuthorship W2972640888A5054393881 @default.
• W2972640888 hasAuthorship W2972640888A5056913085 @default.
• W2972640888 hasAuthorship W2972640888A5065608841 @default.
• W2972640888 hasAuthorship W2972640888A5078011550 @default.
• W2972640888 hasBestOaLocation W29726408881 @default.
• W2972640888 hasConcept C101414908 @default.
• W2972640888 hasConcept C126322002 @default.
• W2972640888 hasConcept C141071460 @default.
• W2972640888 hasConcept C170033053 @default.
• W2972640888 hasConcept C199343813 @default.
• W2972640888 hasConcept C2776541429 @default.
• W2972640888 hasConcept C2778614594 @default.
• W2972640888 hasConcept C2779134260 @default.
• W2972640888 hasConcept C2779240191 @default.
• W2972640888 hasConcept C2780338112 @default.
• W2972640888 hasConcept C2780385504 @default.
• W2972640888 hasConcept C2781411149 @default.
• W2972640888 hasConcept C71924100 @default.
• W2972640888 hasConceptScore W2972640888C101414908 @default.
• W2972640888 hasConceptScore W2972640888C126322002 @default.
• W2972640888 hasConceptScore W2972640888C141071460 @default.
• W2972640888 hasConceptScore W2972640888C170033053 @default.
• W2972640888 hasConceptScore W2972640888C199343813 @default.
• W2972640888 hasConceptScore W2972640888C2776541429 @default.
• W2972640888 hasConceptScore W2972640888C2778614594 @default.
• W2972640888 hasConceptScore W2972640888C2779134260 @default.
• W2972640888 hasConceptScore W2972640888C2779240191 @default.
• W2972640888 hasConceptScore W2972640888C2780338112 @default.
• W2972640888 hasConceptScore W2972640888C2780385504 @default.
• W2972640888 hasConceptScore W2972640888C2781411149 @default.
• W2972640888 hasConceptScore W2972640888C71924100 @default.
• W2972640888 hasIssue "9" @default.
• W2972640888 hasLocation W29726408881 @default.
• W2972640888 hasLocation W29726408882 @default.
• W2972640888 hasLocation W29726408883 @default.
• W2972640888 hasLocation W29726408884 @default.
• W2972640888 hasLocation W29726408885 @default.
• W2972640888 hasLocation W29726408886 @default.
• W2972640888 hasLocation W29726408887 @default.
• W2972640888 hasLocation W29726408888 @default.
• W2972640888 hasOpenAccess W2972640888 @default.
• W2972640888 hasPrimaryLocation W29726408881 @default.
• W2972640888 hasRelatedWork W2095213076 @default.
• W2972640888 hasRelatedWork W2163766559 @default.
• W2972640888 hasRelatedWork W2176158768 @default.
• W2972640888 hasRelatedWork W2347233032 @default.
• W2972640888 hasRelatedWork W2353286404 @default.
• W2972640888 hasRelatedWork W2565159973 @default.
• W2972640888 hasRelatedWork W2589424220 @default.
• W2972640888 hasRelatedWork W2908578951 @default.
• W2972640888 hasRelatedWork W4323310030 @default.

• next