Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972654985> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2972654985 endingPage "119" @default.
- W2972654985 startingPage "119" @default.
- W2972654985 abstract "INTRODUCTION: Fat grafting is a valuable technique in soft-tissue reconstruction. However, ischemia of the grafted tissue with subsequent necrosis and tissue loss impede us from having satisfying long-term results. Recently, the quality and quantity (QQ) culture has been established to increase the vasculogenic potential of endothelial progenitor cells in peripheral blood-derived mononuclear cells (MNCs). Our experiment was designed to test whether QQ-cultured MNC (MNC-QQ) can contribute to vasculogenesis in the human fat graft and decrease the tissue loss. METHODS: Adipose tissue and peripheral blood were harvested from healthy subjects. Fat grafts were created with peripheral blood-derived MNC (N = 16), MNC-QQ (N = 16), and stromal vascular fraction (N = 16) before grafting in BALB/c nude mice, and compared to nonenriched control fat grafts (N = 16). Grafts were explanted after 1 and 7 weeks and analyzed by weight persistence, immunohistochemistry, and quantitative polymerase chain reaction. RESULTS: Weight persistence after 7 weeks was significantly higher in the MNC-QQ group (89.8% ± 3.5%) and SVF group (90.1 ± 4.2) compared to control (70.4% ± 6.3%). With 96.6 ± 6.5 vessels/mm2, grafts in the MNC-QQ group had the most dense vessel network and scored significantly better than control (70.4 ± 5.6 vessels/mm2). MNC-QQ exerted a direct effect on vasculogenesis by integrating in vessels, and a paracrine VEGF-mediated effect. Tissue consisting of fibrosis and perilipin-positive adipocytes was unchanged among all groups. CONCLUSIONS: QQ-cultured MNC containing endothelial progenitor cell stimulates the formation of a blood vessel network in the fat graft and enhances the graft survival, indicating its potential for clinical fat grafting." @default.
- W2972654985 created "2019-09-19" @default.
- W2972654985 creator A5010379899 @default.
- W2972654985 creator A5013774025 @default.
- W2972654985 creator A5015087794 @default.
- W2972654985 creator A5026380231 @default.
- W2972654985 creator A5051442523 @default.
- W2972654985 creator A5053047794 @default.
- W2972654985 creator A5057916809 @default.
- W2972654985 creator A5071325678 @default.
- W2972654985 creator A5081965607 @default.
- W2972654985 creator A5083099954 @default.
- W2972654985 creator A5091310908 @default.
- W2972654985 date "2019-08-01" @default.
- W2972654985 modified "2023-09-27" @default.
- W2972654985 title "Quality- and Quantity-cultured Peripheral Blood Mononuclear Cell Improve the Fat Graft Vascularization and Survival" @default.
- W2972654985 doi "https://doi.org/10.1097/01.gox.0000584908.40073.80" @default.
- W2972654985 hasPublicationYear "2019" @default.
- W2972654985 type Work @default.
- W2972654985 sameAs 2972654985 @default.
- W2972654985 citedByCount "0" @default.
- W2972654985 crossrefType "journal-article" @default.
- W2972654985 hasAuthorship W2972654985A5010379899 @default.
- W2972654985 hasAuthorship W2972654985A5013774025 @default.
- W2972654985 hasAuthorship W2972654985A5015087794 @default.
- W2972654985 hasAuthorship W2972654985A5026380231 @default.
- W2972654985 hasAuthorship W2972654985A5051442523 @default.
- W2972654985 hasAuthorship W2972654985A5053047794 @default.
- W2972654985 hasAuthorship W2972654985A5057916809 @default.
- W2972654985 hasAuthorship W2972654985A5071325678 @default.
- W2972654985 hasAuthorship W2972654985A5081965607 @default.
- W2972654985 hasAuthorship W2972654985A5083099954 @default.
- W2972654985 hasAuthorship W2972654985A5091310908 @default.
- W2972654985 hasBestOaLocation W29726549851 @default.
- W2972654985 hasConcept C126322002 @default.
- W2972654985 hasConcept C137061746 @default.
- W2972654985 hasConcept C142724271 @default.
- W2972654985 hasConcept C16685009 @default.
- W2972654985 hasConcept C16930146 @default.
- W2972654985 hasConcept C170493617 @default.
- W2972654985 hasConcept C171089720 @default.
- W2972654985 hasConcept C201750760 @default.
- W2972654985 hasConcept C202751555 @default.
- W2972654985 hasConcept C2780152582 @default.
- W2972654985 hasConcept C2780394083 @default.
- W2972654985 hasConcept C2780559512 @default.
- W2972654985 hasConcept C2780745355 @default.
- W2972654985 hasConcept C28328180 @default.
- W2972654985 hasConcept C55493867 @default.
- W2972654985 hasConcept C60781801 @default.
- W2972654985 hasConcept C71924100 @default.
- W2972654985 hasConcept C7876069 @default.
- W2972654985 hasConcept C86803240 @default.
- W2972654985 hasConcept C95444343 @default.
- W2972654985 hasConceptScore W2972654985C126322002 @default.
- W2972654985 hasConceptScore W2972654985C137061746 @default.
- W2972654985 hasConceptScore W2972654985C142724271 @default.
- W2972654985 hasConceptScore W2972654985C16685009 @default.
- W2972654985 hasConceptScore W2972654985C16930146 @default.
- W2972654985 hasConceptScore W2972654985C170493617 @default.
- W2972654985 hasConceptScore W2972654985C171089720 @default.
- W2972654985 hasConceptScore W2972654985C201750760 @default.
- W2972654985 hasConceptScore W2972654985C202751555 @default.
- W2972654985 hasConceptScore W2972654985C2780152582 @default.
- W2972654985 hasConceptScore W2972654985C2780394083 @default.
- W2972654985 hasConceptScore W2972654985C2780559512 @default.
- W2972654985 hasConceptScore W2972654985C2780745355 @default.
- W2972654985 hasConceptScore W2972654985C28328180 @default.
- W2972654985 hasConceptScore W2972654985C55493867 @default.
- W2972654985 hasConceptScore W2972654985C60781801 @default.
- W2972654985 hasConceptScore W2972654985C71924100 @default.
- W2972654985 hasConceptScore W2972654985C7876069 @default.
- W2972654985 hasConceptScore W2972654985C86803240 @default.
- W2972654985 hasConceptScore W2972654985C95444343 @default.
- W2972654985 hasIssue "8S-1" @default.
- W2972654985 hasLocation W29726549851 @default.
- W2972654985 hasLocation W29726549852 @default.
- W2972654985 hasLocation W29726549853 @default.
- W2972654985 hasOpenAccess W2972654985 @default.
- W2972654985 hasPrimaryLocation W29726549851 @default.
- W2972654985 hasRelatedWork W1664379753 @default.
- W2972654985 hasRelatedWork W1988194787 @default.
- W2972654985 hasRelatedWork W2008604199 @default.
- W2972654985 hasRelatedWork W2066495913 @default.
- W2972654985 hasRelatedWork W2324345789 @default.
- W2972654985 hasRelatedWork W2348173845 @default.
- W2972654985 hasRelatedWork W2886093265 @default.
- W2972654985 hasRelatedWork W3108289107 @default.
- W2972654985 hasRelatedWork W3115604897 @default.
- W2972654985 hasRelatedWork W4255249089 @default.
- W2972654985 hasVolume "7" @default.
- W2972654985 isParatext "false" @default.
- W2972654985 isRetracted "false" @default.
- W2972654985 magId "2972654985" @default.
- W2972654985 workType "article" @default.