FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972667725> ?p ?o ?g. }

• W2972667725 endingPage "e0221936" @default.
• W2972667725 startingPage "e0221936" @default.
• W2972667725 abstract "ToxR and TcpP, two winged helix-turn-helix (w-HTH) family transcription factors, co-activate expression of the toxT promoter in Vibrio cholerae. ToxT then directly regulates a number of genes required for virulence. In addition to co-activation of toxT, ToxR can directly activate the ompU promoter and repress the ompT promoter. Based on a previous study suggesting that certain wing residues of ToxR are preferentially involved in toxT co-activation compared to direct ompU activation, we employed alanine-scanning mutagenesis to determine which residues in the wing of ToxR are required for activation of each promoter. All of the ToxR wing residues tested that were critical for transcriptional activation of toxT and/or ompU were also critical for DNA binding. While some ToxR wing mutants had reduced interaction with TcpP, that reduced interaction did not correlate with a specific defect in toxT activation. Rather, such mutants also affected ompU activation and DNA binding. Based on these findings we conclude that the primary role of the wing of ToxR is to bind DNA, along with the DNA recognition helix of ToxR, and this function is required both for direct activation of ompU and co-activation of toxT." @default.
• W2972667725 created "2019-09-19" @default.
• W2972667725 creator A5014930140 @default.
• W2972667725 creator A5027545880 @default.
• W2972667725 creator A5076458015 @default.
• W2972667725 creator A5091220986 @default.
• W2972667725 date "2019-09-09" @default.
• W2972667725 modified "2023-10-03" @default.
• W2972667725 title "The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU" @default.
• W2972667725 cites W1479962123 @default.
• W2972667725 cites W1670752878 @default.
• W2972667725 cites W1839711456 @default.
• W2972667725 cites W1953071049 @default.
• W2972667725 cites W1971541237 @default.
• W2972667725 cites W1975415672 @default.
• W2972667725 cites W1993888597 @default.
• W2972667725 cites W1995445964 @default.
• W2972667725 cites W2009189380 @default.
• W2972667725 cites W2014843464 @default.
• W2972667725 cites W2027442700 @default.
• W2972667725 cites W2028625767 @default.
• W2972667725 cites W2033210346 @default.
• W2972667725 cites W2039761675 @default.
• W2972667725 cites W2044431824 @default.
• W2972667725 cites W2047842601 @default.
• W2972667725 cites W2053458854 @default.
• W2972667725 cites W2055827889 @default.
• W2972667725 cites W2062139058 @default.
• W2972667725 cites W2068247287 @default.
• W2972667725 cites W2080314452 @default.
• W2972667725 cites W2101241330 @default.
• W2972667725 cites W2110914325 @default.
• W2972667725 cites W2112463766 @default.
• W2972667725 cites W2113086108 @default.
• W2972667725 cites W2113690363 @default.
• W2972667725 cites W2119127986 @default.
• W2972667725 cites W2119442043 @default.
• W2972667725 cites W2125397110 @default.
• W2972667725 cites W2128189068 @default.
• W2972667725 cites W2128560189 @default.
• W2972667725 cites W2129524689 @default.
• W2972667725 cites W2135473823 @default.
• W2972667725 cites W2144191719 @default.
• W2972667725 cites W2144516903 @default.
• W2972667725 cites W2160321020 @default.
• W2972667725 cites W2280283366 @default.
• W2972667725 cites W2610384405 @default.
• W2972667725 cites W2659083529 @default.
• W2972667725 cites W2765289022 @default.
• W2972667725 doi "https://doi.org/10.1371/journal.pone.0221936" @default.
• W2972667725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6733452" @default.
• W2972667725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31498842" @default.
• W2972667725 hasPublicationYear "2019" @default.
• W2972667725 type Work @default.
• W2972667725 sameAs 2972667725 @default.
• W2972667725 citedByCount "11" @default.
• W2972667725 countsByYear W29726677252020 @default.
• W2972667725 countsByYear W29726677252021 @default.
• W2972667725 countsByYear W29726677252022 @default.
• W2972667725 countsByYear W29726677252023 @default.
• W2972667725 crossrefType "journal-article" @default.
• W2972667725 hasAuthorship W2972667725A5014930140 @default.
• W2972667725 hasAuthorship W2972667725A5027545880 @default.
• W2972667725 hasAuthorship W2972667725A5076458015 @default.
• W2972667725 hasAuthorship W2972667725A5091220986 @default.
• W2972667725 hasBestOaLocation W29726677251 @default.
• W2972667725 hasConcept C101762097 @default.
• W2972667725 hasConcept C104317684 @default.
• W2972667725 hasConcept C138885662 @default.
• W2972667725 hasConcept C143065580 @default.
• W2972667725 hasConcept C150194340 @default.
• W2972667725 hasConcept C16318435 @default.
• W2972667725 hasConcept C179926584 @default.
• W2972667725 hasConcept C199487717 @default.
• W2972667725 hasConcept C2778643871 @default.
• W2972667725 hasConcept C41895202 @default.
• W2972667725 hasConcept C523546767 @default.
• W2972667725 hasConcept C54355233 @default.
• W2972667725 hasConcept C552990157 @default.
• W2972667725 hasConcept C86339819 @default.
• W2972667725 hasConcept C86803240 @default.
• W2972667725 hasConcept C94966510 @default.
• W2972667725 hasConcept C95444343 @default.
• W2972667725 hasConceptScore W2972667725C101762097 @default.
• W2972667725 hasConceptScore W2972667725C104317684 @default.
• W2972667725 hasConceptScore W2972667725C138885662 @default.
• W2972667725 hasConceptScore W2972667725C143065580 @default.
• W2972667725 hasConceptScore W2972667725C150194340 @default.
• W2972667725 hasConceptScore W2972667725C16318435 @default.
• W2972667725 hasConceptScore W2972667725C179926584 @default.
• W2972667725 hasConceptScore W2972667725C199487717 @default.
• W2972667725 hasConceptScore W2972667725C2778643871 @default.
• W2972667725 hasConceptScore W2972667725C41895202 @default.
• W2972667725 hasConceptScore W2972667725C523546767 @default.
• W2972667725 hasConceptScore W2972667725C54355233 @default.
• W2972667725 hasConceptScore W2972667725C552990157 @default.
• W2972667725 hasConceptScore W2972667725C86339819 @default.
• W2972667725 hasConceptScore W2972667725C86803240 @default.

• next