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• W2972689018 endingPage "112235" @default.
• W2972689018 startingPage "112235" @default.
• W2972689018 abstract "Adult female rats show greater running output compared with age-matched male rats, and the midbrain dopaminergic system may account for behavioral differences in running output. However, it is unknown if the lower running output in adult males can be regulated by wheel running experience during adolescence, and whether wheel running experience during adolescence will diminish the sex differences in running output during adulthood. We therefore determined and compared the exercise output in adult male and female rats that either had initiated voluntary wheel running only during adulthood or during adolescence. Our results demonstrate that running output in adult males were significantly higher when running was initiated during adolescence, and this higher running output was not significantly different from females. Running output did not differ during adulthood in females when wheel running was initiated during adolescence or during adulthood. Higher running output in females was associated with reduced expression of tyrosine hydroxylase and hyperactivation of calcium/calmodulin-dependent protein kinase II (CaMKII) in the dorsal striatum. Notably, running during adolescence-induced higher exercise output in adult males was associated with hyperactivation of CaMKII in the dorsal striatum, indicating a mechanistic role for CaMKII in running output. Together, the present results indicate sexually dimorphic adaptive biochemical changes in the dorsal striatum in rats that had escalated running activity, and highlight the importance of including sex as a biological variable in exploring neuroplasticity changes that predict enhanced exercise output in a voluntary physical activity paradigm." @default.
• W2972689018 created "2019-09-19" @default.
• W2972689018 creator A5020004061 @default.
• W2972689018 creator A5041667614 @default.
• W2972689018 creator A5042670875 @default.
• W2972689018 creator A5046821859 @default.
• W2972689018 date "2020-01-01" @default.
• W2972689018 modified "2023-10-07" @default.
• W2972689018 title "Voluntary wheel running during adolescence distinctly alters running output in adulthood in male and female rats" @default.
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• W2972689018 doi "https://doi.org/10.1016/j.bbr.2019.112235" @default.
• W2972689018 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6913875" @default.
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• W2972689018 hasPublicationYear "2020" @default.
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