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- W2972782015 abstract "We investigated the anti-cancer activity of [Ag(μ-dicl)]n1 and [AgH(nif)2] 2 complexes against human cancer cell lines (MCF-7, HT-29, and HepG2) and mouse fibroblast (3T3-L1) cell line. Anti-proliferative activity was monitored by XTT cell viability and LDH leakage assays. Cell death mode was evaluated by multi-caspase activity, annexin V cytofluorimetric, MMP, cell cycle arrest, and ROS generation assays. Antioxidant capacity was evaluated on SOD, GPx, GR, and CAT enzymes. The XTT and LDH assay results showed that both complexes exhibited strong cytotoxicity against the tested cancer cell lines. The apoptotic mechanisms of the complexes were demonstrated by loss of MMP and increase in phosphatidylserine translocation, sub-G1 phase, and multi-caspase activity. Besides, both complexes induced the oxidative stress in MCF-7 cells by decreasing the activity of GPx, GR, and CAT enzymes. In conclusion, both Ag(I) complexes, especially 1, warrant for further in vivo evaluation as a new alternative in cancer treatment.HighlightsAg(I) complexes inhibited cell proliferation and induced LDH leakage in human cancer cell lines.Ag(I) complexes induced apoptosis through MMP disruption and ROS generation.Ag(I) complexes mimicked the multi-caspase activity.Ag(I) complexes increased the accumulation of sub-G1 phase.Ag(I) complexes inhibited the activity of antioxidant system enzymes." @default.
- W2972782015 created "2019-09-19" @default.
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- W2972782015 date "2019-09-13" @default.
- W2972782015 modified "2023-09-30" @default.
- W2972782015 title "Silver(I) complexes containing diclofenac and niflumic acid induce apoptosis in human-derived cancer cell lines" @default.
- W2972782015 cites W1122013619 @default.
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- W2972782015 cites W1973153850 @default.
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- W2972782015 doi "https://doi.org/10.1080/13813455.2019.1662454" @default.
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