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• W2972826013 abstract "Abstract Ectopic protein with proper steric structure was efficiently loaded onto the envelope of the F gene-defective BC-PIV vector derived from human parainfluenza virus type 2 (hPIV2) by a reverse genetics method of recombinant virus production. Further, ectopic antigenic peptide was successfully loaded either outside, inside, or at both sides of the envelope of the vector. The BC-PIV vector harboring the Ebola virus GP gene was able to elicit neutralizing antibodies in mice. In addition, BC-PIV with antigenic epitopes of both melanoma gp100 and WT1 tumor antigen induced a CD8+ T-cell-mediated response in tumor-transplanted syngeneic mice. Considering the low pathogenicity and recurrent infections of parental hPIV2, BC-PIV can be used as a versatile vector with high safety for recombinant vaccine development, addressing unmet medical needs." @default.
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• W2972826013 date "2019-09-09" @default.
• W2972826013 modified "2023-10-16" @default.
• W2972826013 title "A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector" @default.
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• W2972826013 doi "https://doi.org/10.1038/s41598-019-49579-y" @default.
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