FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972836615> ?p ?o ?g. }

• W2972836615 endingPage "452" @default.
• W2972836615 startingPage "445" @default.
• W2972836615 abstract "Osteoporosis is a progressive systematic skeletal disorder featured by decreased bone and enhanced risk of fracture due to an uncoupling of bone resorption. Chronic inflammatory response plays an essential role in osteoporosis progression. Unfortunately, the pathogenesis that contributes to osteoporosis still remains unclear. Dual-specificity phosphatase 14 (Dusp14, also known as MKP6) is a MAP kinase phosphatase, and has important roles in regulating various cellular processes. In the study, we attempted to explore the effects of Dusp14 on osteoporosis development. The results indicated that Dusp14 expression was decreased during osteoclast differentiation and that Dusp14 over-expression markedly alleviated osteoclast generation regulated by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL). In M-CSF/RANKL-treated bone marrow-derived cells (BMMs), promoting Dusp14 expression significantly alleviated inflammation and apoptosis by suppressing nuclear factor (NF)-κB and Caspase-3 signaling pathways, respectively. Furthermore, AMP-activated protein kinase (AMPK)-α activation was markedly increased by Dusp14 over-expression in M-CSF/RANKL-incubated BMMs. Importantly, we found that AMPKα blockage obviously abolished the role of Dusp14 in preventing osteoclasts differentiation at least partly via elevating M-CSF/RANKL-elicited inflammation and apoptosis. In vivo, magnesium silicate-induced inflammatory osteoporosis was obviously alleviated in Dusp14 transgenic (TG) mice. Taken together, we defined Dusp14 as an important molecular switch resulting in osteoporosis through an AMPKα-dependent manner." @default.
• W2972836615 created "2019-09-19" @default.
• W2972836615 creator A5033713296 @default.
• W2972836615 creator A5062226113 @default.
• W2972836615 creator A5076942757 @default.
• W2972836615 date "2019-11-01" @default.
• W2972836615 modified "2023-09-23" @default.
• W2972836615 title "Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKα-dependent manner" @default.
• W2972836615 cites W1513928844 @default.
• W2972836615 cites W1717133667 @default.
• W2972836615 cites W1981518028 @default.
• W2972836615 cites W1984833201 @default.
• W2972836615 cites W2033620181 @default.
• W2972836615 cites W2034698186 @default.
• W2972836615 cites W2038965450 @default.
• W2972836615 cites W2048696832 @default.
• W2972836615 cites W2068057432 @default.
• W2972836615 cites W2069677102 @default.
• W2972836615 cites W2103506151 @default.
• W2972836615 cites W2128816394 @default.
• W2972836615 cites W2140883834 @default.
• W2972836615 cites W2159061765 @default.
• W2972836615 cites W2171709369 @default.
• W2972836615 cites W2289906098 @default.
• W2972836615 cites W2290677193 @default.
• W2972836615 cites W2318642498 @default.
• W2972836615 cites W2330722106 @default.
• W2972836615 cites W2552074235 @default.
• W2972836615 cites W2668361924 @default.
• W2972836615 cites W2752685412 @default.
• W2972836615 cites W2766313289 @default.
• W2972836615 cites W2801730642 @default.
• W2972836615 cites W4214942744 @default.
• W2972836615 doi "https://doi.org/10.1016/j.bbrc.2019.07.091" @default.
• W2972836615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31526569" @default.
• W2972836615 hasPublicationYear "2019" @default.
• W2972836615 type Work @default.
• W2972836615 sameAs 2972836615 @default.
• W2972836615 citedByCount "3" @default.
• W2972836615 countsByYear W29728366152021 @default.
• W2972836615 countsByYear W29728366152023 @default.
• W2972836615 crossrefType "journal-article" @default.
• W2972836615 hasAuthorship W2972836615A5033713296 @default.
• W2972836615 hasAuthorship W2972836615A5062226113 @default.
• W2972836615 hasAuthorship W2972836615A5076942757 @default.
• W2972836615 hasConcept C126322002 @default.
• W2972836615 hasConcept C134018914 @default.
• W2972836615 hasConcept C170493617 @default.
• W2972836615 hasConcept C184235292 @default.
• W2972836615 hasConcept C185592680 @default.
• W2972836615 hasConcept C2776033226 @default.
• W2972836615 hasConcept C2776541429 @default.
• W2972836615 hasConcept C2776914184 @default.
• W2972836615 hasConcept C2779428903 @default.
• W2972836615 hasConcept C2780124434 @default.
• W2972836615 hasConcept C502942594 @default.
• W2972836615 hasConcept C62478195 @default.
• W2972836615 hasConcept C673006 @default.
• W2972836615 hasConcept C71924100 @default.
• W2972836615 hasConcept C86803240 @default.
• W2972836615 hasConcept C88045685 @default.
• W2972836615 hasConcept C95444343 @default.
• W2972836615 hasConcept C97029542 @default.
• W2972836615 hasConceptScore W2972836615C126322002 @default.
• W2972836615 hasConceptScore W2972836615C134018914 @default.
• W2972836615 hasConceptScore W2972836615C170493617 @default.
• W2972836615 hasConceptScore W2972836615C184235292 @default.
• W2972836615 hasConceptScore W2972836615C185592680 @default.
• W2972836615 hasConceptScore W2972836615C2776033226 @default.
• W2972836615 hasConceptScore W2972836615C2776541429 @default.
• W2972836615 hasConceptScore W2972836615C2776914184 @default.
• W2972836615 hasConceptScore W2972836615C2779428903 @default.
• W2972836615 hasConceptScore W2972836615C2780124434 @default.
• W2972836615 hasConceptScore W2972836615C502942594 @default.
• W2972836615 hasConceptScore W2972836615C62478195 @default.
• W2972836615 hasConceptScore W2972836615C673006 @default.
• W2972836615 hasConceptScore W2972836615C71924100 @default.
• W2972836615 hasConceptScore W2972836615C86803240 @default.
• W2972836615 hasConceptScore W2972836615C88045685 @default.
• W2972836615 hasConceptScore W2972836615C95444343 @default.
• W2972836615 hasConceptScore W2972836615C97029542 @default.
• W2972836615 hasIssue "3" @default.
• W2972836615 hasLocation W29728366151 @default.
• W2972836615 hasLocation W29728366152 @default.
• W2972836615 hasOpenAccess W2972836615 @default.
• W2972836615 hasPrimaryLocation W29728366151 @default.
• W2972836615 hasRelatedWork W1979662128 @default.
• W2972836615 hasRelatedWork W2025062373 @default.
• W2972836615 hasRelatedWork W2029202516 @default.
• W2972836615 hasRelatedWork W2042509724 @default.
• W2972836615 hasRelatedWork W2045966750 @default.
• W2972836615 hasRelatedWork W2124998345 @default.
• W2972836615 hasRelatedWork W2203452075 @default.
• W2972836615 hasRelatedWork W2355303118 @default.
• W2972836615 hasRelatedWork W2961466102 @default.
• W2972836615 hasRelatedWork W2970891634 @default.
• W2972836615 hasVolume "519" @default.
• W2972836615 isParatext "false" @default.

• next