Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972882848> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2972882848 abstract "Approximately 7–10% of the general population and 30% of cancer patients suffer from neuropathic pain, which is induced by the damage or disease of the neurologic structures. Sometimes neuropathic pain is caused by the pressure on a nerve but more often pain is due to the sensitization of the centers in the spinal cord and brain. Some structures become so sensitive to the peripheral pain impulses that they become totally independent of them. Recently neuropathic pain is seen as an activation process of the innate immunologic system. In this area the Toll-like receptors seems to play an important role and many drugs are able to inhibit their activation. Treatment of neuropathic pain depends on the possibility of nerve decompression. However, in many cases, the sensitization is the target for treatment. For this purpose, most useful are gabapentinoids that inhibit influx of calcium across the membrane. Antidepressants (SNRI) such as duloxetine and venlafaxine are also useful as well as tricyclic antidepressants, although the latter are characterized by significant adverse effects. In some types of neuropathic pain 8% capsaicin, as well as 5% lidocaine plasters or different opioids, are successfully used although there is still a lack of sufficient, good quality controlled clinical trials. The description of the role of Toll-like receptors in the pathophysiology of neuropathic pain is a breakthrough in thinking and hope for the future to elaborate new, more effective treatment methods. Palliat Med Pract 2019; 13, 3: 123–128" @default.
- W2972882848 created "2019-09-19" @default.
- W2972882848 creator A5073047612 @default.
- W2972882848 date "2019-09-13" @default.
- W2972882848 modified "2023-09-24" @default.
- W2972882848 title "Neuropathic pain: new mechanisms of action of old drugs" @default.
- W2972882848 doi "https://doi.org/10.5603/pmpi.2019.0016" @default.
- W2972882848 hasPublicationYear "2019" @default.
- W2972882848 type Work @default.
- W2972882848 sameAs 2972882848 @default.
- W2972882848 citedByCount "0" @default.
- W2972882848 crossrefType "journal-article" @default.
- W2972882848 hasAuthorship W2972882848A5073047612 @default.
- W2972882848 hasBestOaLocation W29728828481 @default.
- W2972882848 hasConcept C142724271 @default.
- W2972882848 hasConcept C15744967 @default.
- W2972882848 hasConcept C169760540 @default.
- W2972882848 hasConcept C197934379 @default.
- W2972882848 hasConcept C203014093 @default.
- W2972882848 hasConcept C204787440 @default.
- W2972882848 hasConcept C2775991916 @default.
- W2972882848 hasConcept C2776217527 @default.
- W2972882848 hasConcept C2776468701 @default.
- W2972882848 hasConcept C2777107010 @default.
- W2972882848 hasConcept C2780149897 @default.
- W2972882848 hasConcept C2780764818 @default.
- W2972882848 hasConcept C2908647359 @default.
- W2972882848 hasConcept C42219234 @default.
- W2972882848 hasConcept C71924100 @default.
- W2972882848 hasConcept C98274493 @default.
- W2972882848 hasConcept C99454951 @default.
- W2972882848 hasConceptScore W2972882848C142724271 @default.
- W2972882848 hasConceptScore W2972882848C15744967 @default.
- W2972882848 hasConceptScore W2972882848C169760540 @default.
- W2972882848 hasConceptScore W2972882848C197934379 @default.
- W2972882848 hasConceptScore W2972882848C203014093 @default.
- W2972882848 hasConceptScore W2972882848C204787440 @default.
- W2972882848 hasConceptScore W2972882848C2775991916 @default.
- W2972882848 hasConceptScore W2972882848C2776217527 @default.
- W2972882848 hasConceptScore W2972882848C2776468701 @default.
- W2972882848 hasConceptScore W2972882848C2777107010 @default.
- W2972882848 hasConceptScore W2972882848C2780149897 @default.
- W2972882848 hasConceptScore W2972882848C2780764818 @default.
- W2972882848 hasConceptScore W2972882848C2908647359 @default.
- W2972882848 hasConceptScore W2972882848C42219234 @default.
- W2972882848 hasConceptScore W2972882848C71924100 @default.
- W2972882848 hasConceptScore W2972882848C98274493 @default.
- W2972882848 hasConceptScore W2972882848C99454951 @default.
- W2972882848 hasLocation W29728828481 @default.
- W2972882848 hasOpenAccess W2972882848 @default.
- W2972882848 hasPrimaryLocation W29728828481 @default.
- W2972882848 hasRelatedWork W116501248 @default.
- W2972882848 hasRelatedWork W1520338020 @default.
- W2972882848 hasRelatedWork W2044085041 @default.
- W2972882848 hasRelatedWork W2053971092 @default.
- W2972882848 hasRelatedWork W2055437867 @default.
- W2972882848 hasRelatedWork W2055711558 @default.
- W2972882848 hasRelatedWork W2064469413 @default.
- W2972882848 hasRelatedWork W2080938027 @default.
- W2972882848 hasRelatedWork W2123134015 @default.
- W2972882848 hasRelatedWork W2320262341 @default.
- W2972882848 hasRelatedWork W2353231234 @default.
- W2972882848 hasRelatedWork W2605663867 @default.
- W2972882848 hasRelatedWork W2794084717 @default.
- W2972882848 hasRelatedWork W2969743588 @default.
- W2972882848 hasRelatedWork W2977606683 @default.
- W2972882848 hasRelatedWork W31040855 @default.
- W2972882848 hasRelatedWork W3116745050 @default.
- W2972882848 hasRelatedWork W90534654 @default.
- W2972882848 hasRelatedWork W2183010088 @default.
- W2972882848 hasRelatedWork W2188014095 @default.
- W2972882848 isParatext "false" @default.
- W2972882848 isRetracted "false" @default.
- W2972882848 magId "2972882848" @default.
- W2972882848 workType "article" @default.