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- W2972883669 abstract "We propose a unifying perspective of heart failure in patients with type 2 diabetes mellitus. The reasoning is as follows: cellular responses to fuel overload include dysregulated insulin signaling, impaired mitochondrial respiration, reactive oxygen species formation, and the accumulation of certain metabolites, collectively termed glucolipotoxicity. As a consequence, cardiac function is impaired, with intracellular calcium cycling and diastolic dysfunction as an early manifestation. In this setting, increasing glucose uptake by insulin or insulin sensitizing agents only worsens the disrupted fuel homeostasis of the heart. Conversely, restricting fuel supply by means of caloric restriction, surgical intervention, or certain pharmacologic agents will improve cardiac function by restoring metabolic homeostasis. The concept is borne out by clinical interventions, all of which unload the heart from metabolic stress." @default.
- W2972883669 created "2019-09-19" @default.
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- W2972883669 date "2020-03-01" @default.
- W2972883669 modified "2023-10-16" @default.
- W2972883669 title "Strategies of Unloading the Failing Heart from Metabolic Stress" @default.
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- W2972883669 doi "https://doi.org/10.1016/j.amjmed.2019.08.035" @default.
- W2972883669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054139" @default.
- W2972883669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31520618" @default.
- W2972883669 hasPublicationYear "2020" @default.
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