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• W2972885998 abstract "In meiosis, multiple different DNA sequence motifs help to position homologous recombination at hotspots in the genome. How do the seemingly disparate cis-acting regulatory modules each promote locally the activity of the basal recombination machinery? We defined molecular mechanisms of action for five different hotspot-activating DNA motifs (M26, CCAAT, Oligo-C, 4095, 4156) located independently at the same site within the ade6 locus of the fission yeast Schizosaccharomyces pombe Each motif promoted meiotic recombination (i.e., is active) within this context, and this activity required the respective binding proteins (transcription factors Atf1, Pcr1, Php2, Php3, Php5, Rst2). High-resolution analyses of chromatin structure by nucleosome scanning assays revealed that each motif triggers the displacement of nucleosomes surrounding the hotspot motif in meiosis. This chromatin remodeling required the respective sequence-specific binding proteins, was constitutive for two motifs, and was enhanced meiotically for three others. Hotspot activity of each motif strongly required the ATP-dependent chromatin remodeling enzyme Snf22 (Snf2/Swi2), with lesser dependence on Gcn5, Mst2, and Hrp3. These findings support a model in which most meiotic recombination hotspots are positioned by the binding of transcription factors to their respective DNA sites. The functional redundancy of multiple, sequence-specific protein-DNA complexes converges upon shared chromatin remodeling pathways that help provide the basal recombination machinery (Spo11/Rec12 complex) access to its DNA substrates within chromatin." @default.
• W2972885998 created "2019-09-19" @default.
• W2972885998 creator A5006089537 @default.
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• W2972885998 creator A5068210347 @default.
• W2972885998 date "2019-11-01" @default.
• W2972885998 modified "2023-10-11" @default.
• W2972885998 title "Diverse DNA Sequence Motifs Activate Meiotic Recombination Hotspots Through a Common Chromatin Remodeling Pathway" @default.
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• W2972885998 cites W1918698168 @default.
• W2972885998 cites W1954272065 @default.
• W2972885998 cites W1966361889 @default.
• W2972885998 cites W1972513815 @default.
• W2972885998 cites W1973405970 @default.
• W2972885998 cites W1982553713 @default.
• W2972885998 cites W1987555050 @default.
• W2972885998 cites W1992076531 @default.
• W2972885998 cites W2001319692 @default.
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• W2972885998 cites W2013550946 @default.
• W2972885998 cites W2021353981 @default.
• W2972885998 cites W2021733542 @default.
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• W2972885998 doi "https://doi.org/10.1534/genetics.119.302679" @default.
• W2972885998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6827382" @default.
• W2972885998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33954703" @default.
• W2972885998 hasPublicationYear "2019" @default.
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