Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972912589> ?p ?o ?g. }
- W2972912589 endingPage "53" @default.
- W2972912589 startingPage "42" @default.
- W2972912589 abstract "Alzheimer's disease (AD) neuropathology is extremely heterogeneous, and the evolution from preclinical to mild cognitive impairment until dementia is driven by interacting genetic/biological mechanisms not fully captured by current clinical/research criteria. We characterized the heterogeneous “construct” of AD through a cerebrospinal fluid biomarker-guided stratification approach. We analyzed 5 validated pathophysiological cerebrospinal fluid biomarkers (Aβ1-42, t-tau, p-tau181, NFL, YKL-40) in 113 participants (healthy controls [N = 20], subjective memory complainers [N = 36], mild cognitive impairment [N = 20], and AD dementia [N = 37], age: 66.7 ± 10.4, 70.4 ± 7.7, 71.7 ± 8.4, 76.2 ± 3.5 years [mean ± SD], respectively) using Density-Based Spatial Clustering of Applications with Noise, which does not require a priori determination of the number of clusters. We found 5 distinct clusters (sizes: N = 38, 16, 24, 14, and 21) whose composition was independent of phenotypical groups. Two clusters showed biomarker profiles linked to neurodegenerative processes not associated with classical AD-related pathophysiology. One cluster was characterized by the neuroinflammation biomarker YKL-40. Combining nonlinear data aggregation with informative biomarkers can generate novel patient strata which are representative of cellular/molecular pathophysiology and may aid in predicting disease evolution and mechanistic drug response." @default.
- W2972912589 created "2019-09-19" @default.
- W2972912589 creator A5002348728 @default.
- W2972912589 creator A5005778444 @default.
- W2972912589 creator A5009712890 @default.
- W2972912589 creator A5010629974 @default.
- W2972912589 creator A5016497611 @default.
- W2972912589 creator A5018024665 @default.
- W2972912589 creator A5020944505 @default.
- W2972912589 creator A5021647808 @default.
- W2972912589 creator A5021920622 @default.
- W2972912589 creator A5024848742 @default.
- W2972912589 creator A5031924662 @default.
- W2972912589 creator A5032131314 @default.
- W2972912589 creator A5035330581 @default.
- W2972912589 creator A5035338217 @default.
- W2972912589 creator A5035612340 @default.
- W2972912589 creator A5037109052 @default.
- W2972912589 creator A5037665944 @default.
- W2972912589 creator A5039123084 @default.
- W2972912589 creator A5046900294 @default.
- W2972912589 creator A5052883385 @default.
- W2972912589 creator A5054788080 @default.
- W2972912589 creator A5061637255 @default.
- W2972912589 creator A5061951766 @default.
- W2972912589 creator A5064008420 @default.
- W2972912589 creator A5068377025 @default.
- W2972912589 creator A5068394264 @default.
- W2972912589 creator A5069086884 @default.
- W2972912589 creator A5069514442 @default.
- W2972912589 creator A5074168134 @default.
- W2972912589 creator A5075596948 @default.
- W2972912589 creator A5075804608 @default.
- W2972912589 creator A5078876988 @default.
- W2972912589 creator A5079458580 @default.
- W2972912589 creator A5079766290 @default.
- W2972912589 creator A5079882077 @default.
- W2972912589 creator A5084534846 @default.
- W2972912589 creator A5085814761 @default.
- W2972912589 creator A5087099309 @default.
- W2972912589 creator A5089882765 @default.
- W2972912589 creator A5090536391 @default.
- W2972912589 creator A5090558659 @default.
- W2972912589 creator A5090830124 @default.
- W2972912589 creator A5091618250 @default.
- W2972912589 date "2019-11-01" @default.
- W2972912589 modified "2023-10-10" @default.
- W2972912589 title "Biomarker-guided clustering of Alzheimer's disease clinical syndromes" @default.
- W2972912589 cites W1575230904 @default.
- W2972912589 cites W1993571512 @default.
- W2972912589 cites W2013391120 @default.
- W2972912589 cites W2018821242 @default.
- W2972912589 cites W2042440292 @default.
- W2972912589 cites W2079651848 @default.
- W2972912589 cites W2085851888 @default.
- W2972912589 cites W2086197761 @default.
- W2972912589 cites W2093508373 @default.
- W2972912589 cites W2099570666 @default.
- W2972912589 cites W2106931873 @default.
- W2972912589 cites W2115017507 @default.
- W2972912589 cites W2116709840 @default.
- W2972912589 cites W2129497119 @default.
- W2972912589 cites W2129654888 @default.
- W2972912589 cites W2132066584 @default.
- W2972912589 cites W2134396625 @default.
- W2972912589 cites W2149489931 @default.
- W2972912589 cites W2156220037 @default.
- W2972912589 cites W2157110881 @default.
- W2972912589 cites W2291435159 @default.
- W2972912589 cites W2309442902 @default.
- W2972912589 cites W2313430655 @default.
- W2972912589 cites W2327547544 @default.
- W2972912589 cites W2469570354 @default.
- W2972912589 cites W2470863390 @default.
- W2972912589 cites W2473313434 @default.
- W2972912589 cites W2513016934 @default.
- W2972912589 cites W2518545320 @default.
- W2972912589 cites W2521236458 @default.
- W2972912589 cites W2522754681 @default.
- W2972912589 cites W2582524520 @default.
- W2972912589 cites W2586074729 @default.
- W2972912589 cites W2591661570 @default.
- W2972912589 cites W2594139905 @default.
- W2972912589 cites W2615249314 @default.
- W2972912589 cites W2743373469 @default.
- W2972912589 cites W2745191127 @default.
- W2972912589 cites W2772609666 @default.
- W2972912589 cites W2782660935 @default.
- W2972912589 cites W2782731988 @default.
- W2972912589 cites W2788507110 @default.
- W2972912589 cites W2789817872 @default.
- W2972912589 cites W2790952242 @default.
- W2972912589 cites W2791543129 @default.
- W2972912589 cites W2798054687 @default.
- W2972912589 cites W2798236352 @default.
- W2972912589 cites W2803346494 @default.
- W2972912589 cites W2805257646 @default.
- W2972912589 cites W2808696240 @default.