Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972923050> ?p ?o ?g. }
- W2972923050 endingPage "429" @default.
- W2972923050 startingPage "417" @default.
- W2972923050 abstract "Abstract Glioblastoma (GBM) is the most frequent and aggressive primary tumor in the central nervous system. Previously, the secretion of CXCL12 in the brain subventricular zones has been shown to attract GBM cells and protect against irradiation. However, the exact molecular mechanism behind this radioprotection is still unknown. Here, we demonstrate that CXCL12 modulates the phosphorylation of MAP kinases and their regulator, the nuclear MAP kinase phosphatase 1 (MKP1). We further show that MKP1 is able to decrease GBM cell death and promote DNA repair after irradiation by regulating major apoptotic players, such as Jun-N-terminal kinase, and by stabilizing the DNA repair protein RAD51. Increases in MKP1 levels caused by different corticoid treatments should be reexamined for GBM patients, particularly during their radiotherapy sessions, in order to prevent or to delay the relapses of this tumor." @default.
- W2972923050 created "2019-09-19" @default.
- W2972923050 creator A5011087733 @default.
- W2972923050 creator A5014777472 @default.
- W2972923050 creator A5015034172 @default.
- W2972923050 creator A5016223161 @default.
- W2972923050 creator A5028798264 @default.
- W2972923050 creator A5032724244 @default.
- W2972923050 creator A5041986818 @default.
- W2972923050 creator A5060762878 @default.
- W2972923050 creator A5082999758 @default.
- W2972923050 creator A5083206670 @default.
- W2972923050 creator A5085901747 @default.
- W2972923050 date "2019-08-31" @default.
- W2972923050 modified "2023-09-23" @default.
- W2972923050 title "MKP1 phosphatase is recruited by CXCL12 in glioblastoma cells and plays a role in DNA strand breaks repair" @default.
- W2972923050 cites W1989678310 @default.
- W2972923050 cites W2001544973 @default.
- W2972923050 cites W2009790690 @default.
- W2972923050 cites W2010336934 @default.
- W2972923050 cites W2011842532 @default.
- W2972923050 cites W2024727509 @default.
- W2972923050 cites W2046138697 @default.
- W2972923050 cites W2060475031 @default.
- W2972923050 cites W2082831924 @default.
- W2972923050 cites W2100774604 @default.
- W2972923050 cites W2105284981 @default.
- W2972923050 cites W2108343283 @default.
- W2972923050 cites W2109107700 @default.
- W2972923050 cites W2113942802 @default.
- W2972923050 cites W2119924720 @default.
- W2972923050 cites W2128827814 @default.
- W2972923050 cites W2144847992 @default.
- W2972923050 cites W2158985124 @default.
- W2972923050 cites W2161289668 @default.
- W2972923050 cites W2168253141 @default.
- W2972923050 cites W2172708546 @default.
- W2972923050 cites W2221248255 @default.
- W2972923050 cites W2253785907 @default.
- W2972923050 cites W2274721126 @default.
- W2972923050 cites W2326556817 @default.
- W2972923050 cites W2410946291 @default.
- W2972923050 cites W2469069584 @default.
- W2972923050 cites W2490921156 @default.
- W2972923050 cites W2523133038 @default.
- W2972923050 cites W2554553980 @default.
- W2972923050 cites W2556655162 @default.
- W2972923050 cites W2569221217 @default.
- W2972923050 cites W2606054097 @default.
- W2972923050 cites W2620801796 @default.
- W2972923050 cites W2680461124 @default.
- W2972923050 cites W2732346161 @default.
- W2972923050 cites W2745043236 @default.
- W2972923050 cites W2748516402 @default.
- W2972923050 cites W2773703040 @default.
- W2972923050 cites W2777214868 @default.
- W2972923050 cites W2887162196 @default.
- W2972923050 cites W2894671340 @default.
- W2972923050 cites W2896467153 @default.
- W2972923050 doi "https://doi.org/10.1093/carcin/bgz151" @default.
- W2972923050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31504251" @default.
- W2972923050 hasPublicationYear "2019" @default.
- W2972923050 type Work @default.
- W2972923050 sameAs 2972923050 @default.
- W2972923050 citedByCount "3" @default.
- W2972923050 countsByYear W29729230502021 @default.
- W2972923050 countsByYear W29729230502022 @default.
- W2972923050 crossrefType "journal-article" @default.
- W2972923050 hasAuthorship W2972923050A5011087733 @default.
- W2972923050 hasAuthorship W2972923050A5014777472 @default.
- W2972923050 hasAuthorship W2972923050A5015034172 @default.
- W2972923050 hasAuthorship W2972923050A5016223161 @default.
- W2972923050 hasAuthorship W2972923050A5028798264 @default.
- W2972923050 hasAuthorship W2972923050A5032724244 @default.
- W2972923050 hasAuthorship W2972923050A5041986818 @default.
- W2972923050 hasAuthorship W2972923050A5060762878 @default.
- W2972923050 hasAuthorship W2972923050A5082999758 @default.
- W2972923050 hasAuthorship W2972923050A5083206670 @default.
- W2972923050 hasAuthorship W2972923050A5085901747 @default.
- W2972923050 hasBestOaLocation W29729230501 @default.
- W2972923050 hasConcept C11960822 @default.
- W2972923050 hasConcept C134935766 @default.
- W2972923050 hasConcept C136834591 @default.
- W2972923050 hasConcept C143425029 @default.
- W2972923050 hasConcept C178666793 @default.
- W2972923050 hasConcept C184235292 @default.
- W2972923050 hasConcept C2777542384 @default.
- W2972923050 hasConcept C2779012473 @default.
- W2972923050 hasConcept C28328180 @default.
- W2972923050 hasConcept C502942594 @default.
- W2972923050 hasConcept C54355233 @default.
- W2972923050 hasConcept C552990157 @default.
- W2972923050 hasConcept C86803240 @default.
- W2972923050 hasConcept C95444343 @default.
- W2972923050 hasConceptScore W2972923050C11960822 @default.
- W2972923050 hasConceptScore W2972923050C134935766 @default.
- W2972923050 hasConceptScore W2972923050C136834591 @default.
- W2972923050 hasConceptScore W2972923050C143425029 @default.