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• W2972923840 endingPage "4558" @default.
• W2972923840 startingPage "4558" @default.
• W2972923840 abstract "Candida albicans is a polymorphic fungus responsible for mucosal and skin infections. Candida cells establish themselves into biofilm communities resistant to most currently available antifungal agents. An increase of severe infections ensuing in fungal septic shock in elderly or immunosuppressed patients, along with the emergence of drug-resistant strains, urge the need for the development of alternative antifungal agents. In the search for novel antifungal drugs our laboratory demonstrated that two human ribonucleases from the vertebrate-specific RNaseA superfamily, hRNase3 and hRNase7, display a high anticandidal activity. In a previous work, we proved that the N-terminal region of the RNases was sufficient to reproduce most of the parental protein bactericidal activity. Next, we explored their potency against a fungal pathogen. Here, we have tested the N-terminal derived peptides that correspond to the eight human canonical RNases (RN1-8) against planktonic cells and biofilms of C. albicans. RN3 and RN7 peptides displayed the most potent inhibitory effect with a mechanism of action characterized by cell-wall binding, membrane permeabilization and biofilm eradication activities. Both peptides are able to eradicate planktonic and sessile cells, and to alter their gene expression, reinforcing its role as a lead candidate to develop novel antifungal and antibiofilm therapies." @default.
• W2972923840 created "2019-09-19" @default.
• W2972923840 creator A5006915669 @default.
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• W2972923840 creator A5067145798 @default.
• W2972923840 creator A5072672798 @default.
• W2972923840 creator A5091216330 @default.
• W2972923840 date "2019-09-14" @default.
• W2972923840 modified "2023-09-26" @default.
• W2972923840 title "Insight into the Antifungal Mechanism of Action of Human RNase N-terminus Derived Peptides" @default.
• W2972923840 cites W1498823518 @default.
• W2972923840 cites W1600518717 @default.
• W2972923840 cites W1846616724 @default.
• W2972923840 cites W1964252630 @default.
• W2972923840 cites W1964546003 @default.
• W2972923840 cites W1969711244 @default.
• W2972923840 cites W1971218895 @default.
• W2972923840 cites W1977241485 @default.
• W2972923840 cites W1980132051 @default.
• W2972923840 cites W1984674703 @default.
• W2972923840 cites W1985816651 @default.
• W2972923840 cites W1986836541 @default.
• W2972923840 cites W1990436439 @default.
• W2972923840 cites W1991149656 @default.
• W2972923840 cites W1991488616 @default.
• W2972923840 cites W1992450378 @default.
• W2972923840 cites W1997152791 @default.
• W2972923840 cites W1997868832 @default.
• W2972923840 cites W1998601156 @default.
• W2972923840 cites W2000495088 @default.
• W2972923840 cites W2002666618 @default.
• W2972923840 cites W2009031433 @default.
• W2972923840 cites W2012064808 @default.
• W2972923840 cites W2016247087 @default.
• W2972923840 cites W2024074827 @default.
• W2972923840 cites W2027644963 @default.
• W2972923840 cites W2028138612 @default.
• W2972923840 cites W2031909430 @default.
• W2972923840 cites W2041504118 @default.
• W2972923840 cites W2054602599 @default.
• W2972923840 cites W2056782021 @default.
• W2972923840 cites W2062282451 @default.
• W2972923840 cites W2082441977 @default.
• W2972923840 cites W2086484104 @default.
• W2972923840 cites W2094300155 @default.
• W2972923840 cites W2102621484 @default.
• W2972923840 cites W2105743061 @default.
• W2972923840 cites W2109073452 @default.
• W2972923840 cites W2115372426 @default.
• W2972923840 cites W2124716790 @default.
• W2972923840 cites W2135623637 @default.
• W2972923840 cites W2147735231 @default.
• W2972923840 cites W2151183338 @default.
• W2972923840 cites W2152142388 @default.
• W2972923840 cites W2159326061 @default.
• W2972923840 cites W2159347501 @default.
• W2972923840 cites W2169487227 @default.
• W2972923840 cites W2170683413 @default.
• W2972923840 cites W2170764510 @default.
• W2972923840 cites W2174046412 @default.
• W2972923840 cites W2175270296 @default.
• W2972923840 cites W2230270032 @default.
• W2972923840 cites W2252911663 @default.
• W2972923840 cites W2287827867 @default.
• W2972923840 cites W2323453898 @default.
• W2972923840 cites W2332028486 @default.
• W2972923840 cites W2338180334 @default.
• W2972923840 cites W2344481781 @default.
• W2972923840 cites W237973401 @default.
• W2972923840 cites W2404010169 @default.
• W2972923840 cites W2415385378 @default.
• W2972923840 cites W2431337743 @default.
• W2972923840 cites W2500842273 @default.
• W2972923840 cites W2507236629 @default.
• W2972923840 cites W2516616885 @default.
• W2972923840 cites W2557546772 @default.
• W2972923840 cites W2559853894 @default.
• W2972923840 cites W2562261325 @default.
• W2972923840 cites W2585392292 @default.
• W2972923840 cites W2588436517 @default.
• W2972923840 cites W2592450576 @default.
• W2972923840 cites W2605235260 @default.
• W2972923840 cites W2607320059 @default.
• W2972923840 cites W2614095332 @default.
• W2972923840 cites W2616552386 @default.
• W2972923840 cites W2734826884 @default.
• W2972923840 cites W2745913634 @default.
• W2972923840 cites W2792847166 @default.
• W2972923840 cites W2800799562 @default.
• W2972923840 cites W2800910598 @default.
• W2972923840 cites W2801515807 @default.
• W2972923840 cites W2801674411 @default.
• W2972923840 cites W2803219518 @default.
• W2972923840 cites W2811376207 @default.
• W2972923840 cites W2884875215 @default.
• W2972923840 cites W2907406488 @default.

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