FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2972967929> ?p ?o ?g. }

• W2972967929 endingPage "496" @default.
• W2972967929 startingPage "489" @default.
• W2972967929 abstract "Gemcitabine (GEM) is the drug used as first line to treat pancreatic cancer, one of the most devastating human tumors. This peculiar type of tumor develops resistance to several drugs, including GEM, due to its desmoplastic reaction and other features. The GEM chemoresistance has been investigated at molecular level aiming to find a pathway whose inhibition or activation should overcome it. Through next-generation sequencing was performed a chemogenomic assay of GEM using Saccharomyces cerevisiae as model cell and the results showed that more than 40% of genes related to GEM response in yeast possess unknown or dubious function. We choose two yeast mutants to individually validate the fitness defect results observed by chemogenomic assay, Δhmt1 and Δcsi1, and it was found that in addition to some already described pathways involved in GEM resistance, cells deficient in deneddylation enzyme Cop9 Signalosome Interactor 1 (Csi1p) presented a high sensitivity to GEM. This was confirmed by individual growth analyses of Δcsi1 cells exposed to GEM, and this phenotype was reverted with CSI1 complementation gene. Csi1p is a well-characterized homolog equivalent to human Csn6 subunit of COP9 signalosome (CSN) involved in deneddylation process. We highlighted too that epigenetic alterations, such as methylation mediated by protein arginine methyltransferase 1, play an important role in regulating gemcitabine treatment resistance. Our results point out new unexplored molecular pathways that can be used to overcome GEM resistance: the inhibition of CSN and the arginine methyltransferase activities." @default.
• W2972967929 created "2019-09-19" @default.
• W2972967929 creator A5011740095 @default.
• W2972967929 creator A5049074479 @default.
• W2972967929 creator A5066089417 @default.
• W2972967929 creator A5071033413 @default.
• W2972967929 creator A5080217844 @default.
• W2972967929 date "2019-09-12" @default.
• W2972967929 modified "2023-10-18" @default.
• W2972967929 title "Chemogenomic study of gemcitabine using Saccharomyces cerevisiae as model cell—molecular insights about chemoresistance" @default.
• W2972967929 cites W1914408012 @default.
• W2972967929 cites W1989183186 @default.
• W2972967929 cites W1989697374 @default.
• W2972967929 cites W1994624068 @default.
• W2972967929 cites W2000465781 @default.
• W2972967929 cites W2014031830 @default.
• W2972967929 cites W2019784830 @default.
• W2972967929 cites W2023518810 @default.
• W2972967929 cites W2023571913 @default.
• W2972967929 cites W2032742826 @default.
• W2972967929 cites W2044642858 @default.
• W2972967929 cites W2045246542 @default.
• W2972967929 cites W2048793404 @default.
• W2972967929 cites W2054850848 @default.
• W2972967929 cites W2064906202 @default.
• W2972967929 cites W2086840140 @default.
• W2972967929 cites W2111952405 @default.
• W2972967929 cites W2116777384 @default.
• W2972967929 cites W2118103791 @default.
• W2972967929 cites W2131025996 @default.
• W2972967929 cites W2131070390 @default.
• W2972967929 cites W2153804545 @default.
• W2972967929 cites W2162537150 @default.
• W2972967929 cites W2199339413 @default.
• W2972967929 cites W2327334027 @default.
• W2972967929 cites W2414325687 @default.
• W2972967929 cites W2469500689 @default.
• W2972967929 cites W2528308411 @default.
• W2972967929 cites W2554320328 @default.
• W2972967929 cites W2614817084 @default.
• W2972967929 cites W2753179860 @default.
• W2972967929 cites W2761444903 @default.
• W2972967929 cites W2783002859 @default.
• W2972967929 cites W4294718043 @default.
• W2972967929 doi "https://doi.org/10.1007/s42770-019-00154-7" @default.
• W2972967929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7203405" @default.
• W2972967929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31515725" @default.
• W2972967929 hasPublicationYear "2019" @default.
• W2972967929 type Work @default.
• W2972967929 sameAs 2972967929 @default.
• W2972967929 citedByCount "1" @default.
• W2972967929 countsByYear W29729679292022 @default.
• W2972967929 crossrefType "journal-article" @default.
• W2972967929 hasAuthorship W2972967929A5011740095 @default.
• W2972967929 hasAuthorship W2972967929A5049074479 @default.
• W2972967929 hasAuthorship W2972967929A5066089417 @default.
• W2972967929 hasAuthorship W2972967929A5071033413 @default.
• W2972967929 hasAuthorship W2972967929A5080217844 @default.
• W2972967929 hasBestOaLocation W29729679292 @default.
• W2972967929 hasConcept C121608353 @default.
• W2972967929 hasConcept C126322002 @default.
• W2972967929 hasConcept C2777576037 @default.
• W2972967929 hasConcept C2779222958 @default.
• W2972967929 hasConcept C2780258809 @default.
• W2972967929 hasConcept C41008148 @default.
• W2972967929 hasConcept C54355233 @default.
• W2972967929 hasConcept C60644358 @default.
• W2972967929 hasConcept C70721500 @default.
• W2972967929 hasConcept C71924100 @default.
• W2972967929 hasConcept C86803240 @default.
• W2972967929 hasConceptScore W2972967929C121608353 @default.
• W2972967929 hasConceptScore W2972967929C126322002 @default.
• W2972967929 hasConceptScore W2972967929C2777576037 @default.
• W2972967929 hasConceptScore W2972967929C2779222958 @default.
• W2972967929 hasConceptScore W2972967929C2780258809 @default.
• W2972967929 hasConceptScore W2972967929C41008148 @default.
• W2972967929 hasConceptScore W2972967929C54355233 @default.
• W2972967929 hasConceptScore W2972967929C60644358 @default.
• W2972967929 hasConceptScore W2972967929C70721500 @default.
• W2972967929 hasConceptScore W2972967929C71924100 @default.
• W2972967929 hasConceptScore W2972967929C86803240 @default.
• W2972967929 hasFunder F4320320997 @default.
• W2972967929 hasFunder F4320321091 @default.
• W2972967929 hasFunder F4320322025 @default.
• W2972967929 hasIssue "2" @default.
• W2972967929 hasLocation W29729679291 @default.
• W2972967929 hasLocation W29729679292 @default.
• W2972967929 hasOpenAccess W2972967929 @default.
• W2972967929 hasPrimaryLocation W29729679291 @default.
• W2972967929 hasRelatedWork W1021033144 @default.
• W2972967929 hasRelatedWork W1861787140 @default.
• W2972967929 hasRelatedWork W1970227017 @default.
• W2972967929 hasRelatedWork W2014636677 @default.
• W2972967929 hasRelatedWork W2066889359 @default.
• W2972967929 hasRelatedWork W2068799564 @default.
• W2972967929 hasRelatedWork W2138564427 @default.
• W2972967929 hasRelatedWork W2163823651 @default.
• W2972967929 hasRelatedWork W2600787212 @default.

• next