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• W2972980454 abstract "Summary This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives bearing 2-chloroethyl and oligopeptide moieties was designed and synthesized . The most cytotoxic derivative was triazine with an Ala-Ala-OMe substituent on the ring (compound 7b ). This compound induced time- and dose-dependent cytotoxicity in the DLD-1 and HT-29 colon cancer cell lines. The triazine derivative furthermore induced apoptosis through intracellular signaling pathway attenuation. Compound 7b may be a candidate for further evaluation as a chemotherapeutic agent against colorectal cancer." @default.
• W2972980454 created "2019-09-19" @default.
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• W2972980454 date "2019-09-13" @default.
• W2972980454 modified "2023-10-17" @default.
• W2972980454 title "Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines" @default.
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• W2972980454 doi "https://doi.org/10.1007/s10637-019-00838-9" @default.
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