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- W2972988846 abstract "The Escherichia coli marRAB operon is a paradigm for chromosomally encoded antibiotic resistance. The operon exerts its effect via an encoded transcription factor called MarA that modulates efflux pump and porin expression. In this work, we show that MarA is also a regulator of biofilm formation. Control is mediated by binding of MarA to the intergenic region upstream of the ycgZ-ymgABC operon. The operon, known to influence the formation of curli fibres and colanic acid, is usually expressed during periods of starvation. Hence, the ycgZ-ymgABC promoter is recognised by σ38 (RpoS)-associated RNA polymerase (RNAP). Surprisingly, MarA does not influence σ38 -dependent transcription. Instead, MarA drives transcription by the housekeeping σ70 -associated RNAP. The effects of MarA on ycgZ-ymgABC expression are coupled with biofilm formation by the rcsCDB phosphorelay system, with YcgZ, YmgA and YmgB forming a complex that directly interacts with the histidine kinase domain of RcsC." @default.
- W2972988846 created "2019-09-19" @default.
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- W2972988846 date "2019-09-29" @default.
- W2972988846 modified "2023-10-16" @default.
- W2972988846 title "The <i>Escherichia coli</i> MarA protein regulates the <i>ycgZ</i> ‐ <i>ymgABC</i> operon to inhibit biofilm formation" @default.
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- W2972988846 doi "https://doi.org/10.1111/mmi.14386" @default.
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