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- W2973009393 abstract "Abstract The elderly population is more susceptible to pulmonary infections, including tuberculosis. In this article, we characterize the impact of aging on the phenotype of mouse alveolar macrophages (AMs) and their response to Mycobacterium tuberculosis. Uninfected AMs were isolated from bronchoalveolar lavage of young (3 mo) and old (18 mo) C57BL/6 mice. AMs from old mice expressed higher mRNA levels of CCL2, IFN-β, IL-10, IL-12p40, TNF-α, and MIF than young mice, and old mice contained higher levels of CCL2, IL-1β, IFN-β, and MIF in their alveolar lining fluid. We identified two distinct AM subpopulations, a major CD11c+ CD11b− population and a minor CD11c+ CD11b+ population; the latter was significantly increased in old mice (4-fold). Expression of CD206, TLR2, CD16/CD32, MHC class II, and CD86 was higher in CD11c+ CD11b+ AMs, and these cells expressed monocytic markers Ly6C, CX3CR1, and CD115, suggesting monocytic origin. Sorted CD11c+ CD11b+ AMs from old mice expressed higher mRNA levels of CCL2, IL-1β, and IL-6, whereas CD11c+ CD11b− AMs expressed higher mRNA levels of immune-regulatory cytokines IFN-β and IL-10. CD11c+ CD11b+ AMs phagocytosed significantly more M. tuberculosis, which expressed higher RNA levels of genes required for M. tuberculosis survival. Our studies identify two distinct AM populations in old mice: a resident population and an increased CD11c+ CD11b+ AM subpopulation expressing monocytic markers, a unique inflammatory signature, and enhanced M. tuberculosis phagocytosis and survival when compared with resident CD11c+ CD11b− AMs, which are more immune regulatory in nature." @default.
- W2973009393 created "2019-09-19" @default.
- W2973009393 creator A5003839986 @default.
- W2973009393 creator A5009709203 @default.
- W2973009393 creator A5026808662 @default.
- W2973009393 creator A5027549998 @default.
- W2973009393 creator A5043420038 @default.
- W2973009393 creator A5070140298 @default.
- W2973009393 creator A5090657616 @default.
- W2973009393 date "2019-10-15" @default.
- W2973009393 modified "2023-10-11" @default.
- W2973009393 title "Identification of an Increased Alveolar Macrophage Subpopulation in Old Mice That Displays Unique Inflammatory Characteristics and Is Permissive to <i>Mycobacterium tuberculosis</i> Infection" @default.
- W2973009393 cites W1490524938 @default.
- W2973009393 cites W1514633197 @default.
- W2973009393 cites W1524998078 @default.
- W2973009393 cites W1532427044 @default.
- W2973009393 cites W1535252929 @default.
- W2973009393 cites W1544053969 @default.
- W2973009393 cites W1549522998 @default.
- W2973009393 cites W1557707473 @default.
- W2973009393 cites W1838101013 @default.
- W2973009393 cites W1864461701 @default.
- W2973009393 cites W1901576288 @default.
- W2973009393 cites W1913299325 @default.
- W2973009393 cites W1921523468 @default.
- W2973009393 cites W1946912519 @default.
- W2973009393 cites W1956258286 @default.
- W2973009393 cites W1966100182 @default.
- W2973009393 cites W1967131562 @default.
- W2973009393 cites W1967994686 @default.
- W2973009393 cites W1968267504 @default.
- W2973009393 cites W1969619052 @default.
- W2973009393 cites W1973433801 @default.
- W2973009393 cites W1976273400 @default.
- W2973009393 cites W1980872490 @default.
- W2973009393 cites W1988598225 @default.
- W2973009393 cites W2004135191 @default.
- W2973009393 cites W2008808919 @default.
- W2973009393 cites W2023316354 @default.
- W2973009393 cites W2026377947 @default.
- W2973009393 cites W2026578487 @default.
- W2973009393 cites W2026874780 @default.
- W2973009393 cites W2029129613 @default.
- W2973009393 cites W2033135715 @default.
- W2973009393 cites W2036632702 @default.
- W2973009393 cites W2040739057 @default.
- W2973009393 cites W2041189421 @default.
- W2973009393 cites W2059890964 @default.
- W2973009393 cites W2062085316 @default.
- W2973009393 cites W2068009038 @default.
- W2973009393 cites W2071057295 @default.
- W2973009393 cites W2072462631 @default.
- W2973009393 cites W2078035421 @default.
- W2973009393 cites W2079027141 @default.
- W2973009393 cites W2082402714 @default.
- W2973009393 cites W2084628319 @default.
- W2973009393 cites W2086440596 @default.
- W2973009393 cites W2092068607 @default.
- W2973009393 cites W2092404576 @default.
- W2973009393 cites W2092708419 @default.
- W2973009393 cites W2100646399 @default.
- W2973009393 cites W2100902668 @default.
- W2973009393 cites W2103153413 @default.
- W2973009393 cites W2103793744 @default.
- W2973009393 cites W2104058942 @default.
- W2973009393 cites W2107168469 @default.
- W2973009393 cites W2107277218 @default.
- W2973009393 cites W2107953671 @default.
- W2973009393 cites W2108928286 @default.
- W2973009393 cites W2110456507 @default.
- W2973009393 cites W2110591588 @default.
- W2973009393 cites W2112991260 @default.
- W2973009393 cites W2121499583 @default.
- W2973009393 cites W2122445785 @default.
- W2973009393 cites W2123694117 @default.
- W2973009393 cites W2133286922 @default.
- W2973009393 cites W2136188258 @default.
- W2973009393 cites W2137798077 @default.
- W2973009393 cites W2139744167 @default.
- W2973009393 cites W2139928865 @default.
- W2973009393 cites W2141077333 @default.
- W2973009393 cites W2141320958 @default.
- W2973009393 cites W2141526752 @default.
- W2973009393 cites W2141922592 @default.
- W2973009393 cites W2143135577 @default.
- W2973009393 cites W2143500103 @default.
- W2973009393 cites W2144310026 @default.
- W2973009393 cites W2148361935 @default.
- W2973009393 cites W2148579227 @default.
- W2973009393 cites W2151586546 @default.
- W2973009393 cites W2153406260 @default.
- W2973009393 cites W2157527480 @default.
- W2973009393 cites W2158070898 @default.
- W2973009393 cites W2158838767 @default.
- W2973009393 cites W2164663656 @default.
- W2973009393 cites W2165725087 @default.
- W2973009393 cites W2167701137 @default.
- W2973009393 cites W2168944089 @default.