Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973016989> ?p ?o ?g. }
- W2973016989 abstract "The absence of a clinically relevant animal model addressing the typical immune characteristics of hepatocellular cancer (HCC) has significantly impeded elucidation of the underlying mechanisms and development of innovative immunotherapeutic strategies. To develop an ideal animal model recapitulating human HCC, immunocompetent male C57BL/6J mice first receive a carbon tetrachloride (CCl4) injection to induce liver fibrosis, then receive histologically-normal oncogenic hepatocytes from young male SV40 T antigen (TAg)-transgenic mice (MTD2) by intra-splenic (ISPL) inoculation. Androgen generated in recipient male mice at puberty initiates TAg expression under control of a liver-specific promoter. As a result, the transferred hepatocytes become cancer cells and form tumor masses in the setting of liver fibrosis/cirrhosis. This novel model mimics human HCC initiation and progression in the context of liver fibrosis/cirrhosis and reflects the most typical features of human HCC including immune dysfunction." @default.
- W2973016989 created "2019-09-19" @default.
- W2973016989 creator A5000341566 @default.
- W2973016989 creator A5006875608 @default.
- W2973016989 creator A5040371543 @default.
- W2973016989 creator A5065871160 @default.
- W2973016989 creator A5065897181 @default.
- W2973016989 creator A5070298378 @default.
- W2973016989 creator A5086997032 @default.
- W2973016989 date "2019-09-12" @default.
- W2973016989 modified "2023-10-18" @default.
- W2973016989 title "An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis" @default.
- W2973016989 cites W1493940088 @default.
- W2973016989 cites W1970060716 @default.
- W2973016989 cites W1983734516 @default.
- W2973016989 cites W1985199927 @default.
- W2973016989 cites W2015897371 @default.
- W2973016989 cites W2017352677 @default.
- W2973016989 cites W2017792524 @default.
- W2973016989 cites W2039475508 @default.
- W2973016989 cites W2042699075 @default.
- W2973016989 cites W2081127603 @default.
- W2973016989 cites W2096322385 @default.
- W2973016989 cites W2102724983 @default.
- W2973016989 cites W2117692326 @default.
- W2973016989 cites W2152925951 @default.
- W2973016989 cites W2153935627 @default.
- W2973016989 cites W2158965278 @default.
- W2973016989 cites W2163403599 @default.
- W2973016989 cites W2168006608 @default.
- W2973016989 cites W2284593700 @default.
- W2973016989 cites W2341369626 @default.
- W2973016989 cites W2418967275 @default.
- W2973016989 cites W2494328932 @default.
- W2973016989 cites W2520085757 @default.
- W2973016989 cites W2560367415 @default.
- W2973016989 cites W2569595372 @default.
- W2973016989 cites W2569886419 @default.
- W2973016989 cites W2586399611 @default.
- W2973016989 cites W2592187743 @default.
- W2973016989 cites W2603526557 @default.
- W2973016989 cites W2613223694 @default.
- W2973016989 cites W2624163993 @default.
- W2973016989 cites W2728903533 @default.
- W2973016989 cites W2737207041 @default.
- W2973016989 cites W2750607700 @default.
- W2973016989 cites W2786818729 @default.
- W2973016989 cites W2895336603 @default.
- W2973016989 cites W334309946 @default.
- W2973016989 cites W4211183069 @default.
- W2973016989 cites W4243625103 @default.
- W2973016989 cites W4300625153 @default.
- W2973016989 doi "https://doi.org/10.3791/59368" @default.
- W2973016989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408290" @default.
- W2973016989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31566616" @default.
- W2973016989 hasPublicationYear "2019" @default.
- W2973016989 type Work @default.
- W2973016989 sameAs 2973016989 @default.
- W2973016989 citedByCount "5" @default.
- W2973016989 countsByYear W29730169892020 @default.
- W2973016989 countsByYear W29730169892021 @default.
- W2973016989 countsByYear W29730169892022 @default.
- W2973016989 countsByYear W29730169892023 @default.
- W2973016989 crossrefType "journal-article" @default.
- W2973016989 hasAuthorship W2973016989A5000341566 @default.
- W2973016989 hasAuthorship W2973016989A5006875608 @default.
- W2973016989 hasAuthorship W2973016989A5040371543 @default.
- W2973016989 hasAuthorship W2973016989A5065871160 @default.
- W2973016989 hasAuthorship W2973016989A5065897181 @default.
- W2973016989 hasAuthorship W2973016989A5070298378 @default.
- W2973016989 hasAuthorship W2973016989A5086997032 @default.
- W2973016989 hasBestOaLocation W29730169892 @default.
- W2973016989 hasConcept C102230213 @default.
- W2973016989 hasConcept C104317684 @default.
- W2973016989 hasConcept C121608353 @default.
- W2973016989 hasConcept C126322002 @default.
- W2973016989 hasConcept C141035611 @default.
- W2973016989 hasConcept C142724271 @default.
- W2973016989 hasConcept C151730666 @default.
- W2973016989 hasConcept C202751555 @default.
- W2973016989 hasConcept C203014093 @default.
- W2973016989 hasConcept C2776200302 @default.
- W2973016989 hasConcept C2776231280 @default.
- W2973016989 hasConcept C2776914184 @default.
- W2973016989 hasConcept C2777214474 @default.
- W2973016989 hasConcept C2778019345 @default.
- W2973016989 hasConcept C2779343474 @default.
- W2973016989 hasConcept C2780559512 @default.
- W2973016989 hasConcept C502942594 @default.
- W2973016989 hasConcept C55493867 @default.
- W2973016989 hasConcept C71924100 @default.
- W2973016989 hasConcept C86803240 @default.
- W2973016989 hasConcept C8891405 @default.
- W2973016989 hasConceptScore W2973016989C102230213 @default.
- W2973016989 hasConceptScore W2973016989C104317684 @default.
- W2973016989 hasConceptScore W2973016989C121608353 @default.
- W2973016989 hasConceptScore W2973016989C126322002 @default.
- W2973016989 hasConceptScore W2973016989C141035611 @default.
- W2973016989 hasConceptScore W2973016989C142724271 @default.
- W2973016989 hasConceptScore W2973016989C151730666 @default.