FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973123432> ?p ?o ?g. }

• W2973123432 abstract "The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus primarily on the β subunit and II B genes. We explored MHC II A in Leach's storm-petrel, a seabird with two expressed, polymorphic II B genes. We found two II A genes, Ocle-DAA and Ocle-DBA, in contrast to the single II A gene in chicken and duck. In exon 2 which encodes the α1 domain, the storm-petrel II A genes differed strongly from each other but showed little within-gene polymorphism in 30 individuals: just one Ocle-DAA allele, and three Ocle-DBA alleles differing from each other by single non-synonymous substitutions. In a comparable sample, the two II B genes had nine markedly diverged alleles each. Differences between the α1 domains of Ocle-DAA and Ocle-DBA showed signatures of positive selection, but mainly at non-peptide-binding site (PBS) positions. In contrast, positive selection within and between the II B genes corresponded to putative PBS codons. Phylogenetic analysis of the conserved α2 domain did not reveal deep or well-supported lineages of II A genes in birds, in contrast to the pronounced differentiation of DQA, DPA, and DRA isotypes in mammals. This uncertain homology complicates efforts to compare levels of functional variation and modes of evolution of II A genes across taxa." @default.
• W2973123432 created "2019-09-19" @default.
• W2973123432 creator A5001961737 @default.
• W2973123432 creator A5018908411 @default.
• W2973123432 creator A5028930267 @default.
• W2973123432 creator A5051944786 @default.
• W2973123432 creator A5086136415 @default.
• W2973123432 creator A5089464511 @default.
• W2973123432 creator A5090039940 @default.
• W2973123432 date "2019-09-01" @default.
• W2973123432 modified "2023-09-24" @default.
• W2973123432 title "Divergence between genes but limited allelic polymorphism in two MHC class II A genes in Leach’s storm-petrels Oceanodroma leucorhoa" @default.
• W2973123432 cites W1550819366 @default.
• W2973123432 cites W1608535143 @default.
• W2973123432 cites W1652383174 @default.
• W2973123432 cites W1888067941 @default.
• W2973123432 cites W1967253926 @default.
• W2973123432 cites W1970455769 @default.
• W2973123432 cites W1978166253 @default.
• W2973123432 cites W1981470925 @default.
• W2973123432 cites W1983935363 @default.
• W2973123432 cites W1984316285 @default.
• W2973123432 cites W1988778626 @default.
• W2973123432 cites W1997321853 @default.
• W2973123432 cites W2003100695 @default.
• W2973123432 cites W2003218712 @default.
• W2973123432 cites W2003785366 @default.
• W2973123432 cites W2006995093 @default.
• W2973123432 cites W2027753643 @default.
• W2973123432 cites W2041842205 @default.
• W2973123432 cites W2053553320 @default.
• W2973123432 cites W2054334091 @default.
• W2973123432 cites W2058661270 @default.
• W2973123432 cites W2061304220 @default.
• W2973123432 cites W2067007779 @default.
• W2973123432 cites W2070758477 @default.
• W2973123432 cites W2071936885 @default.
• W2973123432 cites W2075381224 @default.
• W2973123432 cites W2080956086 @default.
• W2973123432 cites W2081123727 @default.
• W2973123432 cites W2108077810 @default.
• W2973123432 cites W2110335151 @default.
• W2973123432 cites W2122051412 @default.
• W2973123432 cites W2127832297 @default.
• W2973123432 cites W2130783116 @default.
• W2973123432 cites W2135622355 @default.
• W2973123432 cites W2137907434 @default.
• W2973123432 cites W2140083627 @default.
• W2973123432 cites W2143197765 @default.
• W2973123432 cites W2152207030 @default.
• W2973123432 cites W2154845780 @default.
• W2973123432 cites W2159409522 @default.
• W2973123432 cites W2167170000 @default.
• W2973123432 cites W2169220682 @default.
• W2973123432 cites W2170565120 @default.
• W2973123432 cites W2190660133 @default.
• W2973123432 cites W2253414912 @default.
• W2973123432 cites W2342987911 @default.
• W2973123432 cites W2469285598 @default.
• W2973123432 cites W2512912852 @default.
• W2973123432 cites W2588435718 @default.
• W2973123432 cites W2606590632 @default.
• W2973123432 cites W2626623941 @default.
• W2973123432 cites W2771006912 @default.
• W2973123432 cites W2787414552 @default.
• W2973123432 cites W2790505494 @default.
• W2973123432 cites W2799794365 @default.
• W2973123432 cites W2799941152 @default.
• W2973123432 cites W2884175033 @default.
• W2973123432 cites W2901783023 @default.
• W2973123432 cites W2919645370 @default.
• W2973123432 doi "https://doi.org/10.1007/s00251-019-01130-z" @default.
• W2973123432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7050443" @default.
• W2973123432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31506710" @default.
• W2973123432 hasPublicationYear "2019" @default.
• W2973123432 type Work @default.
• W2973123432 sameAs 2973123432 @default.
• W2973123432 citedByCount "3" @default.
• W2973123432 countsByYear W29731234322022 @default.
• W2973123432 countsByYear W29731234322023 @default.
• W2973123432 crossrefType "journal-article" @default.
• W2973123432 hasAuthorship W2973123432A5001961737 @default.
• W2973123432 hasAuthorship W2973123432A5018908411 @default.
• W2973123432 hasAuthorship W2973123432A5028930267 @default.
• W2973123432 hasAuthorship W2973123432A5051944786 @default.
• W2973123432 hasAuthorship W2973123432A5086136415 @default.
• W2973123432 hasAuthorship W2973123432A5089464511 @default.
• W2973123432 hasAuthorship W2973123432A5090039940 @default.
• W2973123432 hasBestOaLocation W29731234322 @default.
• W2973123432 hasConcept C104317684 @default.
• W2973123432 hasConcept C137848329 @default.
• W2973123432 hasConcept C180754005 @default.
• W2973123432 hasConcept C193252679 @default.
• W2973123432 hasConcept C207936829 @default.
• W2973123432 hasConcept C2778814158 @default.
• W2973123432 hasConcept C54355233 @default.
• W2973123432 hasConcept C86803240 @default.
• W2973123432 hasConceptScore W2973123432C104317684 @default.
• W2973123432 hasConceptScore W2973123432C137848329 @default.
• W2973123432 hasConceptScore W2973123432C180754005 @default.

• next