Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973134422> ?p ?o ?g. }
- W2973134422 abstract "Protein synthesis ends when a ribosome reaches an mRNA stop codon. Release factors (RFs) decode the stop codon, hydrolyze peptidyl-tRNA to release the nascent protein, and then dissociate to allow ribosome recycling. To visualize termination by RF2, we resolved a cryo-EM ensemble of E. coli 70S•RF2 structures at up to 3.3 Å in a single sample. Five structures suggest a highly dynamic termination pathway. Upon peptidyl-tRNA hydrolysis, the CCA end of deacyl-tRNA departs from the peptidyl transferase center. The catalytic GGQ loop of RF2 is rearranged into a long β-hairpin that plugs the peptide tunnel, biasing a nascent protein toward the ribosome exit. Ribosomal intersubunit rotation destabilizes the catalytic RF2 domain on the 50S subunit and disassembles the central intersubunit bridge B2a, resulting in RF2 departure. Our structures visualize how local rearrangements and spontaneous inter-subunit rotation poise the newly-made protein and RF2 to dissociate in preparation for ribosome recycling." @default.
- W2973134422 created "2019-09-19" @default.
- W2973134422 creator A5004824396 @default.
- W2973134422 creator A5007705088 @default.
- W2973134422 creator A5024535974 @default.
- W2973134422 creator A5025300008 @default.
- W2973134422 creator A5086024663 @default.
- W2973134422 date "2019-09-12" @default.
- W2973134422 modified "2023-09-30" @default.
- W2973134422 title "Extensive ribosome and RF2 rearrangements during translation termination" @default.
- W2973134422 cites W1486850686 @default.
- W2973134422 cites W1677689941 @default.
- W2973134422 cites W1838789895 @default.
- W2973134422 cites W1965875917 @default.
- W2973134422 cites W1974436766 @default.
- W2973134422 cites W1974452426 @default.
- W2973134422 cites W1979632234 @default.
- W2973134422 cites W1985441949 @default.
- W2973134422 cites W1986381105 @default.
- W2973134422 cites W1986576285 @default.
- W2973134422 cites W1987460726 @default.
- W2973134422 cites W1989067983 @default.
- W2973134422 cites W1990868071 @default.
- W2973134422 cites W1992657741 @default.
- W2973134422 cites W1993124128 @default.
- W2973134422 cites W2001109229 @default.
- W2973134422 cites W2002193643 @default.
- W2973134422 cites W2003208597 @default.
- W2973134422 cites W2007220609 @default.
- W2973134422 cites W2008739199 @default.
- W2973134422 cites W2009185547 @default.
- W2973134422 cites W2009642956 @default.
- W2973134422 cites W2009844536 @default.
- W2973134422 cites W2010257676 @default.
- W2973134422 cites W2010696782 @default.
- W2973134422 cites W2011469578 @default.
- W2973134422 cites W2012499642 @default.
- W2973134422 cites W2017421343 @default.
- W2973134422 cites W2020942151 @default.
- W2973134422 cites W2022754910 @default.
- W2973134422 cites W2024858227 @default.
- W2973134422 cites W2026384929 @default.
- W2973134422 cites W2027656887 @default.
- W2973134422 cites W2029101220 @default.
- W2973134422 cites W2029249249 @default.
- W2973134422 cites W2031580496 @default.
- W2973134422 cites W2032146255 @default.
- W2973134422 cites W2032279044 @default.
- W2973134422 cites W2041188328 @default.
- W2973134422 cites W2045458431 @default.
- W2973134422 cites W2046889198 @default.
- W2973134422 cites W2048593866 @default.
- W2973134422 cites W2050788001 @default.
- W2973134422 cites W2051146505 @default.
- W2973134422 cites W2054702783 @default.
- W2973134422 cites W2058886590 @default.
- W2973134422 cites W2061327322 @default.
- W2973134422 cites W2068654340 @default.
- W2973134422 cites W2077167882 @default.
- W2973134422 cites W2078726019 @default.
- W2973134422 cites W2087217881 @default.
- W2973134422 cites W2088307810 @default.
- W2973134422 cites W2088327469 @default.
- W2973134422 cites W2089457247 @default.
- W2973134422 cites W2093041571 @default.
- W2973134422 cites W2094987467 @default.
- W2973134422 cites W2099126195 @default.
- W2973134422 cites W2101404563 @default.
- W2973134422 cites W2101730674 @default.
- W2973134422 cites W2101862091 @default.
- W2973134422 cites W2102916349 @default.
- W2973134422 cites W2104382086 @default.
- W2973134422 cites W2105326796 @default.
- W2973134422 cites W2109184569 @default.
- W2973134422 cites W2116458567 @default.
- W2973134422 cites W2124412561 @default.
- W2973134422 cites W2126920222 @default.
- W2973134422 cites W2127285213 @default.
- W2973134422 cites W2129775801 @default.
- W2973134422 cites W2132629607 @default.
- W2973134422 cites W2135985251 @default.
- W2973134422 cites W2136322092 @default.
- W2973134422 cites W2142161929 @default.
- W2973134422 cites W2146173293 @default.
- W2973134422 cites W2146912125 @default.
- W2973134422 cites W2147981074 @default.
- W2973134422 cites W2148843770 @default.
- W2973134422 cites W2150085257 @default.
- W2973134422 cites W2154714625 @default.
- W2973134422 cites W2163689612 @default.
- W2973134422 cites W2171205452 @default.
- W2973134422 cites W2180229411 @default.
- W2973134422 cites W2259984134 @default.
- W2973134422 cites W2337243072 @default.
- W2973134422 cites W2346206575 @default.
- W2973134422 cites W2462274392 @default.
- W2973134422 cites W2524421408 @default.
- W2973134422 cites W2535930359 @default.
- W2973134422 cites W2548199696 @default.
- W2973134422 cites W2558901611 @default.