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- W2973144377 abstract "Consanguineous or cousin marriages are very common in Saudi Arabia. However, owing to limited studies and insufficient knowledge about genetic diseases/disorders, many couples are unaware of the increased health risks for their offspring. Among the inherited and complex diseases from parents' consanguinity, obesity is common; therefore, we examined the prevalence of obesity in the offspring of first-cousin consanguineous couples in Saudi Arabia. In this questionnaire-based study, 657 individuals (mean age = 18.7 ± 10.2 years; age range = 2-65 years) who were residing in Riyadh, Saudi Arabia participated. Among them, almost 90% were native Saudis. Participants mean body mass index (BMI) was 24.5 ± 9.1 kg/m2. Sex- stratified demographic details confirmed a significant association between age and BMI (p < .001). We confirmed that adolescents and adults were more prone to develop obesity. Adults and non-Saudi participants were three times more likely to develop obesity if they had first-cousin consanguineous parents than those who did not. Of the 30% of participants who were obese, 100 will be selected for Phase II, in which we plan to perform exome sequencing." @default.
- W2973144377 created "2019-09-19" @default.
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- W2973144377 date "2020-01-01" @default.
- W2973144377 modified "2023-10-15" @default.
- W2973144377 title "Screening for obesity in the offspring of first-cousin consanguineous couples: A Phase-I study in Saudi Arabia" @default.
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- W2973144377 doi "https://doi.org/10.1016/j.sjbs.2019.09.001" @default.
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