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• W2973154755 abstract "Individuation and organization in complex living multi-level ecosystem occurs as dynamical processes from early ontogeny. The notion of living “holon” displaying dynamic self-assertion and integration is used here to explain the ecosystems dynamic processes. The update of the living holon state according to the continuous change of the dynamic system allows for its viability. This is interpreted as adaptation, selection and organization by the human that observes the system a posteriori from its level. Our model concerns the complex dynamics of the adaptive immune system, integrating holon-lymphocytes that collectively preserve the identity and integrity of the organism. Each lymphocyte individualizes as a dynamic holon-lymphocyte, with somatic gene individuation leading to an individual, singular antigen immunoreceptor type, promoting the self-assertion. In turn, the “Immunoception” allows for perception of the environmental antigenic context, thus integration of the holon in its environment. The self-assertion/integration of holon-lymphocyte starts from fetal stages and is influenced by mother Lamarckian acquired historicity transmissions, a requisite for the integrity of the holobiont-organism. We propose a dynamic model of the perception by holon-lymphocyte, and at the supra-clonal level of the immune system functions that sustain the identity and integrity of the holon-holobiont organism." @default.
• W2973154755 created "2019-09-19" @default.
• W2973154755 creator A5089978204 @default.
• W2973154755 date "2019-09-20" @default.
• W2973154755 modified "2023-10-16" @default.
• W2973154755 title "Individuation and the Organization in Complex Living Ecosystem: Recursive Integration and Self-assertion by Holon-Lymphocytes" @default.
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• W2973154755 doi "https://doi.org/10.1007/s10441-019-09364-w" @default.
• W2973154755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31541308" @default.
• W2973154755 hasPublicationYear "2019" @default.
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