FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973162289> ?p ?o ?g. }

• W2973162289 abstract "Abstract DNA double strand breaks are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure, with high affinity for double strand breaks. It relocates to sites of damage independently of signalling and known sensors and activates downstream signalling cascades for double strand break repair by triggering ATM recruitment, H2AX phosphorylation and the recruitment of proteins of the Homologous Recombination and Non-Homologous End Joining pathways. Our findings indicate that SIRT6 plays a previously uncharacterized role as DNA damage sensor, which is critical for initiating the DNA damage response (DDR). Moreover, other Sirtuins share some DSB binding capacity and DDR activation. SIRT6 activates the DDR, before the repair pathway is chosen, and prevents genomic instability. Our findings place SIRT6 at the top of the DDR and pave the road to dissect the contributions of distinct double strand break sensors in downstream signalling." @default.
• W2973162289 created "2019-09-19" @default.
• W2973162289 creator A5000590470 @default.
• W2973162289 creator A5008169561 @default.
• W2973162289 creator A5015110234 @default.
• W2973162289 creator A5019785229 @default.
• W2973162289 creator A5032679867 @default.
• W2973162289 creator A5038393817 @default.
• W2973162289 creator A5061428121 @default.
• W2973162289 creator A5063593677 @default.
• W2973162289 creator A5072610849 @default.
• W2973162289 creator A5081499228 @default.
• W2973162289 creator A5085223649 @default.
• W2973162289 creator A5091295712 @default.
• W2973162289 date "2019-09-11" @default.
• W2973162289 modified "2023-09-26" @default.
• W2973162289 title "SIRT6 is a DNA Double-Strand Break Sensor" @default.
• W2973162289 cites W1482046317 @default.
• W2973162289 cites W1965531809 @default.
• W2973162289 cites W1972924731 @default.
• W2973162289 cites W1987615467 @default.
• W2973162289 cites W1988280121 @default.
• W2973162289 cites W1988353584 @default.
• W2973162289 cites W1998974491 @default.
• W2973162289 cites W2004257622 @default.
• W2973162289 cites W2010394540 @default.
• W2973162289 cites W2020311873 @default.
• W2973162289 cites W2021161606 @default.
• W2973162289 cites W2022873453 @default.
• W2973162289 cites W2041552603 @default.
• W2973162289 cites W2044836637 @default.
• W2973162289 cites W2054866841 @default.
• W2973162289 cites W2055373932 @default.
• W2973162289 cites W2060247906 @default.
• W2973162289 cites W2061015483 @default.
• W2973162289 cites W2061576857 @default.
• W2973162289 cites W2067328670 @default.
• W2973162289 cites W2070758111 @default.
• W2973162289 cites W2074343204 @default.
• W2973162289 cites W2077436902 @default.
• W2973162289 cites W2080053685 @default.
• W2973162289 cites W2088938499 @default.
• W2973162289 cites W2114404734 @default.
• W2973162289 cites W2128354543 @default.
• W2973162289 cites W2129488204 @default.
• W2973162289 cites W2143049294 @default.
• W2973162289 cites W2145200068 @default.
• W2973162289 cites W2146204567 @default.
• W2973162289 cites W2146637989 @default.
• W2973162289 cites W2157899948 @default.
• W2973162289 cites W2169741450 @default.
• W2973162289 cites W2227508297 @default.
• W2973162289 cites W2271661412 @default.
• W2973162289 cites W2406576771 @default.
• W2973162289 cites W2425965912 @default.
• W2973162289 cites W245720584 @default.
• W2973162289 cites W2485886299 @default.
• W2973162289 cites W2552184863 @default.
• W2973162289 cites W2561742638 @default.
• W2973162289 cites W2598735320 @default.
• W2973162289 cites W2602238152 @default.
• W2973162289 cites W2753229012 @default.
• W2973162289 cites W2758817194 @default.
• W2973162289 cites W2765112310 @default.
• W2973162289 cites W2792384603 @default.
• W2973162289 cites W2792729825 @default.
• W2973162289 cites W2898928670 @default.
• W2973162289 cites W2937386865 @default.
• W2973162289 cites W4211018930 @default.
• W2973162289 doi "https://doi.org/10.1101/765172" @default.
• W2973162289 hasPublicationYear "2019" @default.
• W2973162289 type Work @default.
• W2973162289 sameAs 2973162289 @default.
• W2973162289 citedByCount "0" @default.
• W2973162289 crossrefType "posted-content" @default.
• W2973162289 hasAuthorship W2973162289A5000590470 @default.
• W2973162289 hasAuthorship W2973162289A5008169561 @default.
• W2973162289 hasAuthorship W2973162289A5015110234 @default.
• W2973162289 hasAuthorship W2973162289A5019785229 @default.
• W2973162289 hasAuthorship W2973162289A5032679867 @default.
• W2973162289 hasAuthorship W2973162289A5038393817 @default.
• W2973162289 hasAuthorship W2973162289A5061428121 @default.
• W2973162289 hasAuthorship W2973162289A5063593677 @default.
• W2973162289 hasAuthorship W2973162289A5072610849 @default.
• W2973162289 hasAuthorship W2973162289A5081499228 @default.
• W2973162289 hasAuthorship W2973162289A5085223649 @default.
• W2973162289 hasAuthorship W2973162289A5091295712 @default.
• W2973162289 hasBestOaLocation W29731622891 @default.
• W2973162289 hasConcept C102744134 @default.
• W2973162289 hasConcept C134935766 @default.
• W2973162289 hasConcept C143425029 @default.
• W2973162289 hasConcept C178169997 @default.
• W2973162289 hasConcept C185592680 @default.
• W2973162289 hasConcept C2992406208 @default.
• W2973162289 hasConcept C39743133 @default.
• W2973162289 hasConcept C54355233 @default.
• W2973162289 hasConcept C552990157 @default.
• W2973162289 hasConcept C86803240 @default.
• W2973162289 hasConcept C95444343 @default.
• W2973162289 hasConceptScore W2973162289C102744134 @default.

• next