Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973165727> ?p ?o ?g. }
- W2973165727 abstract "ABSTRACT Thymocytes bearing αβ T cell receptors (TCRαβ) with high affinity for self-peptide-MHC complexes undergo negative selection or are diverted to alternate T cell lineages, a process termed agonist selection. Among thymocytes bearing TCRs restricted to MHC class I, agonist selection can lead to the development of precursors that can home to the gut and give rise to CD8αα-expressing intraepithelial lymphocytes (CD8αα IELs). The factors that influence the choice between negative selection versus CD8αα IEL development remain largely unknown. Using a synchronized thymic tissue slice model that supports both negative selection and CD8αα̣IEL development, we show that the affinity threshold for CD8αα IEL development is higher than for negative selection. We also investigate the impact of peptide presenting cells and cytokines, and the migration patterns associated with these alternative cell fates. Our data highlight the roles of TCR affinity and the thymic microenvironments on T cell fate." @default.
- W2973165727 created "2019-09-19" @default.
- W2973165727 creator A5009041311 @default.
- W2973165727 creator A5039832950 @default.
- W2973165727 creator A5056600229 @default.
- W2973165727 creator A5056609060 @default.
- W2973165727 creator A5079977765 @default.
- W2973165727 date "2019-09-12" @default.
- W2973165727 modified "2023-10-07" @default.
- W2973165727 title "Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes" @default.
- W2973165727 cites W1512887516 @default.
- W2973165727 cites W1559758724 @default.
- W2973165727 cites W1577309031 @default.
- W2973165727 cites W1588625776 @default.
- W2973165727 cites W1702230595 @default.
- W2973165727 cites W1939904335 @default.
- W2973165727 cites W1967800669 @default.
- W2973165727 cites W1975391393 @default.
- W2973165727 cites W1982161183 @default.
- W2973165727 cites W1987683966 @default.
- W2973165727 cites W1988248740 @default.
- W2973165727 cites W1992547979 @default.
- W2973165727 cites W1998603634 @default.
- W2973165727 cites W2003210909 @default.
- W2973165727 cites W2014575353 @default.
- W2973165727 cites W2014634158 @default.
- W2973165727 cites W2016680738 @default.
- W2973165727 cites W2017053957 @default.
- W2973165727 cites W2022613174 @default.
- W2973165727 cites W2029588570 @default.
- W2973165727 cites W2032477135 @default.
- W2973165727 cites W2034402052 @default.
- W2973165727 cites W2047102094 @default.
- W2973165727 cites W2048659881 @default.
- W2973165727 cites W2052776731 @default.
- W2973165727 cites W2061628822 @default.
- W2973165727 cites W2071049632 @default.
- W2973165727 cites W2072267424 @default.
- W2973165727 cites W2078102740 @default.
- W2973165727 cites W2090239659 @default.
- W2973165727 cites W2093902610 @default.
- W2973165727 cites W2096987374 @default.
- W2973165727 cites W2098838729 @default.
- W2973165727 cites W2119312822 @default.
- W2973165727 cites W2119789840 @default.
- W2973165727 cites W2122523262 @default.
- W2973165727 cites W2124282397 @default.
- W2973165727 cites W2125123991 @default.
- W2973165727 cites W2138853264 @default.
- W2973165727 cites W2143774433 @default.
- W2973165727 cites W2148343285 @default.
- W2973165727 cites W2150644622 @default.
- W2973165727 cites W2158450091 @default.
- W2973165727 cites W2162493503 @default.
- W2973165727 cites W2255115671 @default.
- W2973165727 cites W2618404796 @default.
- W2973165727 cites W2668594481 @default.
- W2973165727 cites W2738424312 @default.
- W2973165727 cites W2901872876 @default.
- W2973165727 cites W2945055008 @default.
- W2973165727 cites W64458079 @default.
- W2973165727 doi "https://doi.org/10.1101/761601" @default.
- W2973165727 hasPublicationYear "2019" @default.
- W2973165727 type Work @default.
- W2973165727 sameAs 2973165727 @default.
- W2973165727 citedByCount "0" @default.
- W2973165727 crossrefType "posted-content" @default.
- W2973165727 hasAuthorship W2973165727A5009041311 @default.
- W2973165727 hasAuthorship W2973165727A5039832950 @default.
- W2973165727 hasAuthorship W2973165727A5056600229 @default.
- W2973165727 hasAuthorship W2973165727A5056609060 @default.
- W2973165727 hasAuthorship W2973165727A5079977765 @default.
- W2973165727 hasBestOaLocation W29731657271 @default.
- W2973165727 hasConcept C104317684 @default.
- W2973165727 hasConcept C141231307 @default.
- W2973165727 hasConcept C147483822 @default.
- W2973165727 hasConcept C152605822 @default.
- W2973165727 hasConcept C154317977 @default.
- W2973165727 hasConcept C167672396 @default.
- W2973165727 hasConcept C170493617 @default.
- W2973165727 hasConcept C170627219 @default.
- W2973165727 hasConcept C19317047 @default.
- W2973165727 hasConcept C202751555 @default.
- W2973165727 hasConcept C203014093 @default.
- W2973165727 hasConcept C207936829 @default.
- W2973165727 hasConcept C2776090121 @default.
- W2973165727 hasConcept C2778938600 @default.
- W2973165727 hasConcept C2778954852 @default.
- W2973165727 hasConcept C54355233 @default.
- W2973165727 hasConcept C7386963 @default.
- W2973165727 hasConcept C86803240 @default.
- W2973165727 hasConcept C8891405 @default.
- W2973165727 hasConcept C95444343 @default.
- W2973165727 hasConceptScore W2973165727C104317684 @default.
- W2973165727 hasConceptScore W2973165727C141231307 @default.
- W2973165727 hasConceptScore W2973165727C147483822 @default.
- W2973165727 hasConceptScore W2973165727C152605822 @default.
- W2973165727 hasConceptScore W2973165727C154317977 @default.
- W2973165727 hasConceptScore W2973165727C167672396 @default.
- W2973165727 hasConceptScore W2973165727C170493617 @default.