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- W2973173698 abstract "Zaire ebolavirus (EBOV) is an enveloped negative-sense single-stranded RNA virus of the Filoviridae family and is the etiologic agent of Ebola virus disease (EVD). 1 Baseler L. Chertow D.S. Johnson K.M. Feldmann H. Morens D.M. The pathogenesis of Ebola virus disease. Annu Rev Pathol. 2017; 12: 387-418 Crossref PubMed Scopus (182) Google Scholar EBOV is transmitted through direct contact with infectious body fluids or tissues of an infected individual. Following an average 6-day asymptomatic incubation period, EVD manifests as high fever, myalgias, and progressive prostration. Within approximately 3 days of symptom onset, severe nausea, vomiting, and large-volume diarrhea ensue, and high-level viremia results in widespread infection of multiple cell types and tissues throughout the body. 2 Martines R.B. Ng D.L. Greer P.W. Rollin P.E. Zaki S.R. Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses. J Pathol. 2015; 235: 153-174 Crossref PubMed Scopus (204) Google Scholar Complex pathogenesis includes virally mediated hepatocellular and renal tubular necrosis and an exuberant host response contributing to disordered coagulation, increased vascular permeability, and multiorgan dysfunction or failure." @default.
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- W2973173698 date "2020-01-01" @default.
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- W2973173698 title "Ebola Virus in the Democratic Republic of the Congo" @default.
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- W2973173698 doi "https://doi.org/10.1016/j.chest.2019.08.2183" @default.
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