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- W2973178081 abstract "Unfolded protein response (UPRs) directs adaption or apoptosis depending on the severity of endoplasmic-reticulum (ER) stress. We found that apoptotic signaling by inositol requiring enzyme 1α (IRE1α), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress." @default.
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- W2973178081 date "2019-09-11" @default.
- W2973178081 modified "2023-09-24" @default.
- W2973178081 title "Mitochondrial retrograde signaling to the endoplasmic-reticulum regulates unfolded protein responses" @default.
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- W2973178081 doi "https://doi.org/10.1080/23723556.2019.1659078" @default.
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