FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973187546> ?p ?o ?g. }

• W2973187546 endingPage "1784" @default.
• W2973187546 startingPage "1780" @default.
• W2973187546 abstract "Patients with tetralogy of Fallot (TOF) have abnormal right ventricular (RV) afterload because of residual or recurrent outflow tract obstruction, often with abnormal pulmonary artery (PA) vascular function. The purpose of this study was to determine if RV afterload was independently associated with death and/or heart transplant in patients with TOF. This is a retrospective study of TOF patients that underwent cardiac catheterization for clinical indications at Mayo clinic between 1990 and 2015. Invasively measured RV systolic pressure (RVSP) was used to define RV afterload. To explore clinical utility for echocardiographic estimates of invasive data, correlations between invasive and Doppler-derived indices of RV afterload were examined. Among 266 patients with TOF (age 35 ± 14 years, TOF-pulmonary atresia 117 [44%]), RVSP was 72 ± 28 mm Hg, PA systolic pressure 45 ± 19 mm Hg, mean PA pressure 27 ± 10 mm Hg, pulmonary vascular resistance 4.2 ± 3.1 WU, and PA wedge pressure 14 ± 5 mm Hg. Over a mean follow up of 12.9 years, there were 35 deaths and 4 heart transplants. Invasively measured RVSP (hazard ratio 1.25, 95% confidence interval 1.12 to 1.37; p <0.001) and TOF-pulmonary atresia (hazard ratio 1.18, 95% confidence interval 1.08 to 1.41; p = 0.023) were independent risk factors for death and/or transplant. Doppler-derived RVSP was well-correlated with invasive RVSP (r = 0.92, p <0.001), and was also independently associated with the combined end point. RVSP, a composite measure of RV afterload, is independently prognostic in patients with TOF, and can be reliably assessed using Doppler echocardiography. Further study is required to test whether interventions to reduce RVSP can improve outcomes in patients with TOF. Patients with tetralogy of Fallot (TOF) have abnormal right ventricular (RV) afterload because of residual or recurrent outflow tract obstruction, often with abnormal pulmonary artery (PA) vascular function. The purpose of this study was to determine if RV afterload was independently associated with death and/or heart transplant in patients with TOF. This is a retrospective study of TOF patients that underwent cardiac catheterization for clinical indications at Mayo clinic between 1990 and 2015. Invasively measured RV systolic pressure (RVSP) was used to define RV afterload. To explore clinical utility for echocardiographic estimates of invasive data, correlations between invasive and Doppler-derived indices of RV afterload were examined. Among 266 patients with TOF (age 35 ± 14 years, TOF-pulmonary atresia 117 [44%]), RVSP was 72 ± 28 mm Hg, PA systolic pressure 45 ± 19 mm Hg, mean PA pressure 27 ± 10 mm Hg, pulmonary vascular resistance 4.2 ± 3.1 WU, and PA wedge pressure 14 ± 5 mm Hg. Over a mean follow up of 12.9 years, there were 35 deaths and 4 heart transplants. Invasively measured RVSP (hazard ratio 1.25, 95% confidence interval 1.12 to 1.37; p <0.001) and TOF-pulmonary atresia (hazard ratio 1.18, 95% confidence interval 1.08 to 1.41; p = 0.023) were independent risk factors for death and/or transplant. Doppler-derived RVSP was well-correlated with invasive RVSP (r = 0.92, p <0.001), and was also independently associated with the combined end point. RVSP, a composite measure of RV afterload, is independently prognostic in patients with TOF, and can be reliably assessed using Doppler echocardiography. Further study is required to test whether interventions to reduce RVSP can improve outcomes in patients with TOF." @default.
• W2973187546 created "2019-09-19" @default.
• W2973187546 creator A5000304605 @default.
• W2973187546 creator A5001298175 @default.
• W2973187546 creator A5023305491 @default.
• W2973187546 creator A5030461468 @default.
• W2973187546 creator A5031317277 @default.
• W2973187546 creator A5032577440 @default.
• W2973187546 creator A5052247800 @default.
• W2973187546 creator A5061999743 @default.
• W2973187546 creator A5073165323 @default.
• W2973187546 creator A5075437654 @default.
• W2973187546 date "2019-12-01" @default.
• W2973187546 modified "2023-09-24" @default.
• W2973187546 title "Assessment and Implications of Right Ventricular Afterload in Tetralogy of Fallot" @default.
• W2973187546 cites W14974779 @default.
• W2973187546 cites W1949353815 @default.
• W2973187546 cites W1970771731 @default.
• W2973187546 cites W1974262142 @default.
• W2973187546 cites W1982483328 @default.
• W2973187546 cites W2003164670 @default.
• W2973187546 cites W2022043412 @default.
• W2973187546 cites W2070987439 @default.
• W2973187546 cites W2105380741 @default.
• W2973187546 cites W2117253993 @default.
• W2973187546 cites W2124624517 @default.
• W2973187546 cites W2151673824 @default.
• W2973187546 cites W2155137238 @default.
• W2973187546 cites W2161450347 @default.
• W2973187546 cites W2163346511 @default.
• W2973187546 cites W2169550276 @default.
• W2973187546 cites W2169821142 @default.
• W2973187546 cites W2268216939 @default.
• W2973187546 cites W2313186535 @default.
• W2973187546 cites W2476146068 @default.
• W2973187546 cites W2732895602 @default.
• W2973187546 cites W2766068570 @default.
• W2973187546 cites W2883049150 @default.
• W2973187546 cites W4289887258 @default.
• W2973187546 doi "https://doi.org/10.1016/j.amjcard.2019.08.035" @default.
• W2973187546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31586531" @default.
• W2973187546 hasPublicationYear "2019" @default.
• W2973187546 type Work @default.
• W2973187546 sameAs 2973187546 @default.
• W2973187546 citedByCount "6" @default.
• W2973187546 countsByYear W29731875462020 @default.
• W2973187546 countsByYear W29731875462021 @default.
• W2973187546 countsByYear W29731875462022 @default.
• W2973187546 crossrefType "journal-article" @default.
• W2973187546 hasAuthorship W2973187546A5000304605 @default.
• W2973187546 hasAuthorship W2973187546A5001298175 @default.
• W2973187546 hasAuthorship W2973187546A5023305491 @default.
• W2973187546 hasAuthorship W2973187546A5030461468 @default.
• W2973187546 hasAuthorship W2973187546A5031317277 @default.
• W2973187546 hasAuthorship W2973187546A5032577440 @default.
• W2973187546 hasAuthorship W2973187546A5052247800 @default.
• W2973187546 hasAuthorship W2973187546A5061999743 @default.
• W2973187546 hasAuthorship W2973187546A5073165323 @default.
• W2973187546 hasAuthorship W2973187546A5075437654 @default.
• W2973187546 hasConcept C123576724 @default.
• W2973187546 hasConcept C126322002 @default.
• W2973187546 hasConcept C146556889 @default.
• W2973187546 hasConcept C164705383 @default.
• W2973187546 hasConcept C178853913 @default.
• W2973187546 hasConcept C207103383 @default.
• W2973187546 hasConcept C26635844 @default.
• W2973187546 hasConcept C2777361368 @default.
• W2973187546 hasConcept C2778646171 @default.
• W2973187546 hasConcept C2780074459 @default.
• W2973187546 hasConcept C2780940725 @default.
• W2973187546 hasConcept C44249647 @default.
• W2973187546 hasConcept C71924100 @default.
• W2973187546 hasConceptScore W2973187546C123576724 @default.
• W2973187546 hasConceptScore W2973187546C126322002 @default.
• W2973187546 hasConceptScore W2973187546C146556889 @default.
• W2973187546 hasConceptScore W2973187546C164705383 @default.
• W2973187546 hasConceptScore W2973187546C178853913 @default.
• W2973187546 hasConceptScore W2973187546C207103383 @default.
• W2973187546 hasConceptScore W2973187546C26635844 @default.
• W2973187546 hasConceptScore W2973187546C2777361368 @default.
• W2973187546 hasConceptScore W2973187546C2778646171 @default.
• W2973187546 hasConceptScore W2973187546C2780074459 @default.
• W2973187546 hasConceptScore W2973187546C2780940725 @default.
• W2973187546 hasConceptScore W2973187546C44249647 @default.
• W2973187546 hasConceptScore W2973187546C71924100 @default.
• W2973187546 hasFunder F4320337338 @default.
• W2973187546 hasIssue "11" @default.
• W2973187546 hasLocation W29731875461 @default.
• W2973187546 hasLocation W29731875462 @default.
• W2973187546 hasOpenAccess W2973187546 @default.
• W2973187546 hasPrimaryLocation W29731875461 @default.
• W2973187546 hasRelatedWork W2001243683 @default.
• W2973187546 hasRelatedWork W2013477135 @default.
• W2973187546 hasRelatedWork W2042946359 @default.
• W2973187546 hasRelatedWork W2073555585 @default.
• W2973187546 hasRelatedWork W2386899787 @default.
• W2973187546 hasRelatedWork W2789308579 @default.
• W2973187546 hasRelatedWork W2973187546 @default.

• next