Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973199068> ?p ?o ?g. }
- W2973199068 endingPage "1270" @default.
- W2973199068 startingPage "1258" @default.
- W2973199068 abstract "Curcumin-loaded hybrid magnetic nanoparticles (HMNPs) were formulated using a simple and green method. At first, surface of Fe3O4 nanoparticles was modified using alginate (ALG), and magnetic ALG/Fe3O4 nanoparticles with a size of 33 nm and a zeta potential of -25 mv were prepared. Then, a complex including bovine serum albumin (BSA) and poly((3-acrylamidopropyl)trimethylammonium chloride) (p(APTMACl)) was prepared and optimized. The behavior of the BSA/p(APTMACl) complex was evaluated as a function of pH and protein/polymer ratio by UV-Vis spectroscopy, zeta potential, and DLS analysis. Finally, the hybrid complex of BSA/p(APTMACl)@ALG/Fe3O4 were prepared using mixing of the BSA/p(APTMACl) and ALG/Fe3O4 systems with opposite charges via electrostatic interactions. The prepared BSA/p(APTMACl) @ALG/Fe3O4 complex was named hybrid magnetic nanoparticles (HMNPs) and characterized by UV-Vis spectroscopy, SEM, FT-IR, TGA, XRD, VSM, and AFM. Three samples including pure Fe3O4, ALG/Fe3O4, and the final HMNPs exhibited no cytotoxic effect on MCF-7 breast cancer cell using the MTT assay. MTT assay to test the antitumor activity of bare and encapsulated-curcumin against MCF-7 cells showed BSA/p(APTMACl)@ALG/Fe3O4 nanoparticles are able to stabilize the curcumin anti-cancer drug and also enhancing the antitumor activity of the encapsulated curcumin. After loading of curcumin with a high efficiency of 95%. The accumulative release profiles of curcumin were investigated at 37 °C in phosphate buffered saline (PBS, pH 3 and 7.4). The release of curcumin-loaded HMNPs followed the Korsmeyer-Peppas equation and anomalous (non-fickian) diffusion mechanism at pHs 3 and 7.4." @default.
- W2973199068 created "2019-09-19" @default.
- W2973199068 creator A5056940953 @default.
- W2973199068 creator A5064585402 @default.
- W2973199068 creator A5088955774 @default.
- W2973199068 date "2019-12-01" @default.
- W2973199068 modified "2023-10-03" @default.
- W2973199068 title "pH-responsive hybrid magnetic polyelectrolyte complex based on alginate/BSA as efficient nanocarrier for curcumin encapsulation and delivery" @default.
- W2973199068 cites W1149376991 @default.
- W2973199068 cites W1974606130 @default.
- W2973199068 cites W1986581020 @default.
- W2973199068 cites W1996045291 @default.
- W2973199068 cites W1998271063 @default.
- W2973199068 cites W2011107152 @default.
- W2973199068 cites W2017916544 @default.
- W2973199068 cites W2029473882 @default.
- W2973199068 cites W2037501943 @default.
- W2973199068 cites W2039937126 @default.
- W2973199068 cites W2040236012 @default.
- W2973199068 cites W2043367418 @default.
- W2973199068 cites W2045304921 @default.
- W2973199068 cites W2055942053 @default.
- W2973199068 cites W2061856830 @default.
- W2973199068 cites W2071825757 @default.
- W2973199068 cites W2073002994 @default.
- W2973199068 cites W2082225136 @default.
- W2973199068 cites W2089466578 @default.
- W2973199068 cites W2090683258 @default.
- W2973199068 cites W2103210148 @default.
- W2973199068 cites W2113583716 @default.
- W2973199068 cites W2115439624 @default.
- W2973199068 cites W2132789515 @default.
- W2973199068 cites W2235357267 @default.
- W2973199068 cites W2320740467 @default.
- W2973199068 cites W2324499350 @default.
- W2973199068 cites W2327182012 @default.
- W2973199068 cites W2515879543 @default.
- W2973199068 cites W2550522497 @default.
- W2973199068 cites W2586491410 @default.
- W2973199068 cites W2588646494 @default.
- W2973199068 cites W2607039912 @default.
- W2973199068 cites W2753337691 @default.
- W2973199068 cites W2767584643 @default.
- W2973199068 cites W2787199040 @default.
- W2973199068 cites W2788975672 @default.
- W2973199068 cites W2792856623 @default.
- W2973199068 cites W2796944494 @default.
- W2973199068 cites W2875751174 @default.
- W2973199068 cites W2893041510 @default.
- W2973199068 cites W2897804429 @default.
- W2973199068 cites W2898941899 @default.
- W2973199068 cites W2945344076 @default.
- W2973199068 cites W3166002690 @default.
- W2973199068 cites W4206315036 @default.
- W2973199068 cites W4256080103 @default.
- W2973199068 cites W49061994 @default.
- W2973199068 doi "https://doi.org/10.1016/j.ijbiomac.2019.09.048" @default.
- W2973199068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31518625" @default.
- W2973199068 hasPublicationYear "2019" @default.
- W2973199068 type Work @default.
- W2973199068 sameAs 2973199068 @default.
- W2973199068 citedByCount "22" @default.
- W2973199068 countsByYear W29731990682019 @default.
- W2973199068 countsByYear W29731990682020 @default.
- W2973199068 countsByYear W29731990682021 @default.
- W2973199068 countsByYear W29731990682022 @default.
- W2973199068 countsByYear W29731990682023 @default.
- W2973199068 crossrefType "journal-article" @default.
- W2973199068 hasAuthorship W2973199068A5056940953 @default.
- W2973199068 hasAuthorship W2973199068A5064585402 @default.
- W2973199068 hasAuthorship W2973199068A5088955774 @default.
- W2973199068 hasConcept C127413603 @default.
- W2973199068 hasConcept C13965031 @default.
- W2973199068 hasConcept C153356533 @default.
- W2973199068 hasConcept C155672457 @default.
- W2973199068 hasConcept C171250308 @default.
- W2973199068 hasConcept C178790620 @default.
- W2973199068 hasConcept C18150654 @default.
- W2973199068 hasConcept C185592680 @default.
- W2973199068 hasConcept C192562407 @default.
- W2973199068 hasConcept C2778250585 @default.
- W2973199068 hasConcept C2779820397 @default.
- W2973199068 hasConcept C2780783641 @default.
- W2973199068 hasConcept C42360764 @default.
- W2973199068 hasConcept C43617362 @default.
- W2973199068 hasConcept C521977710 @default.
- W2973199068 hasConcept C55493867 @default.
- W2973199068 hasConcept C62112901 @default.
- W2973199068 hasConcept C86181022 @default.
- W2973199068 hasConcept C86807702 @default.
- W2973199068 hasConcept C87023908 @default.
- W2973199068 hasConceptScore W2973199068C127413603 @default.
- W2973199068 hasConceptScore W2973199068C13965031 @default.
- W2973199068 hasConceptScore W2973199068C153356533 @default.
- W2973199068 hasConceptScore W2973199068C155672457 @default.
- W2973199068 hasConceptScore W2973199068C171250308 @default.
- W2973199068 hasConceptScore W2973199068C178790620 @default.
- W2973199068 hasConceptScore W2973199068C18150654 @default.