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- W2973201586 abstract "Abstract The vimentin network displays remarkable plasticity to support basic cellular functions and reorganizes during cell division. Here, we show that in several cell types vimentin filaments redistribute to the cell cortex during mitosis, forming a robust framework interwoven with cortical actin and affecting its organization. Importantly, the intrinsically disordered tail domain of vimentin is essential for this redistribution, which allows normal mitotic progression. A tailless vimentin mutant forms curly bundles, which remain entangled with dividing chromosomes leading to mitotic catastrophes or asymmetric partitions. Serial deletions of vimentin tail domain gradually impair cortical association and mitosis progression. Disruption of f-actin, but not of microtubules, causes vimentin bundling near the chromosomes. Pathophysiological stimuli, including HIV-protease and lipoxidation, induce similar alterations. Interestingly, full filament formation is dispensable for cortical association, which also occurs in vimentin particles. These results unveil implications of vimentin dynamics in cell division through its interplay with the actin cortex." @default.
- W2973201586 created "2019-09-19" @default.
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- W2973201586 date "2019-09-13" @default.
- W2973201586 modified "2023-10-01" @default.
- W2973201586 title "Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division" @default.
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- W2973201586 doi "https://doi.org/10.1038/s41467-019-12029-4" @default.
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