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- W2973202109 abstract "Abstract The stability and quality of metazoan mRNAs are under microRNA (miRNA)-mediated and nonsense-mediated control. Although UPF1, a core mediator of nonsense-mediated mRNA decay (NMD), mediates the decay of target mRNA in a 3′UTR-length-dependent manner, the detailed mechanism remains unclear. Here, we suggest that 3′UTR-length-dependent mRNA decay is not mediated by nonsense mRNAs but rather by miRNAs that downregulate target mRNAs via Ago-associated UPF1/SMG7. Global analyses of mRNAs in response to UPF1 RNA interference in miRNA-deficient cells reveal that 3′UTR-length-dependent mRNA decay by UPF1 requires canonical miRNA targeting. The destabilization of miRNA targets is accomplished by the combination of Ago2 and UPF1/SMG7, which may recruit the CCR4-NOT deadenylase complex. Indeed, loss of the SMG7-deadenylase complex interaction increases the levels of transcripts regulated by UPF1-SMG7. This UPF1/SMG7-dependent miRNA-mediated mRNA decay pathway may enable miRNA targeting to become more predictable and expand the miRNA-mRNA regulatory network." @default.
- W2973202109 created "2019-09-19" @default.
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- W2973202109 date "2019-09-13" @default.
- W2973202109 modified "2023-09-27" @default.
- W2973202109 title "UPF1/SMG7-dependent microRNA-mediated gene regulation" @default.
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- W2973202109 doi "https://doi.org/10.1038/s41467-019-12123-7" @default.
- W2973202109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6744440" @default.
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