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- W2973207975 abstract "ASP3627 (1) is a potent Janus kinase inhibitor discovered and developed by Astellas Pharma Inc. Here, we report the development of a practical and scalable method for manufacturing ASP3627 featuring a six-reaction telescoping process consisting of DIBAL reduction, hydrolysis, Wittig reaction, cyclization, and a two-step sequence to remove the SEM group. In addition, a simple palladium removal procedure using l-cysteine is described. This method was used to successfully perform the first multikilogram synthesis of ASP3627, producing 30 kg with high purity in excellent overall yield." @default.
- W2973207975 created "2019-09-19" @default.
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- W2973207975 date "2019-09-09" @default.
- W2973207975 modified "2023-10-01" @default.
- W2973207975 title "A Practical and Scalable Method for Manufacturing JAK Inhibitor ASP3627" @default.
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- W2973207975 doi "https://doi.org/10.1021/acs.oprd.9b00269" @default.
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