Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973256189> ?p ?o ?g. }
- W2973256189 abstract "Abstract Traumatic brain injury is a leading cause of death and disability around the world. So far, drugs are not available to repair brain damage. Human mesenchymal stem cell (hMSC) transplantation therapy is a promising approach, although the inflammatory microenvironment of the injured brain affects the efficacy of transplanted hMSCs. We hypothesize that reducing the inflammation in the cerebral microenvironment by reducing pro-inflammatory chemokines prior to hMSC administration will improve the efficacy of hMSC therapy. In a rat model of lateral fluid percussion injury, combined pioglitazone (PG) and hMSC (combination) treatment showed less anxiety-like behavior and improved sensorimotor responses to a noxious cold stimulus. Significant reduction in brain lesion volume, neurodegeneration, microgliosis and astrogliosis were observed after combination treatment. TBI induced expression of inflammatory chemokine CCL20 and IL1-β were significantly decreased in the combination treatment group. Combination treatment significantly increased brain-derived neurotrophic factor (BDNF) level and subventricular zone (SVZ) neurogenesis. Taken together, reducing proinflammatory cytokine expression in the cerebral tissues after TBI by PG administration and prior to hMSC therapy improves the outcome of the therapy in which BDNF could have a role." @default.
- W2973256189 created "2019-09-26" @default.
- W2973256189 creator A5009589418 @default.
- W2973256189 creator A5010321945 @default.
- W2973256189 creator A5027859130 @default.
- W2973256189 creator A5044182575 @default.
- W2973256189 creator A5054520863 @default.
- W2973256189 creator A5055580140 @default.
- W2973256189 creator A5065405485 @default.
- W2973256189 creator A5089465392 @default.
- W2973256189 date "2019-09-20" @default.
- W2973256189 modified "2023-09-23" @default.
- W2973256189 title "Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats" @default.
- W2973256189 cites W1104958192 @default.
- W2973256189 cites W139260680 @default.
- W2973256189 cites W1548786914 @default.
- W2973256189 cites W1609471181 @default.
- W2973256189 cites W1833381290 @default.
- W2973256189 cites W1911548173 @default.
- W2973256189 cites W1959095543 @default.
- W2973256189 cites W1965425745 @default.
- W2973256189 cites W1967075670 @default.
- W2973256189 cites W1968862818 @default.
- W2973256189 cites W1974630536 @default.
- W2973256189 cites W1976839120 @default.
- W2973256189 cites W1982561969 @default.
- W2973256189 cites W1982702072 @default.
- W2973256189 cites W1983936685 @default.
- W2973256189 cites W1990514899 @default.
- W2973256189 cites W1995052009 @default.
- W2973256189 cites W2012658246 @default.
- W2973256189 cites W2012821843 @default.
- W2973256189 cites W2021858341 @default.
- W2973256189 cites W2027363457 @default.
- W2973256189 cites W2042639961 @default.
- W2973256189 cites W2046037876 @default.
- W2973256189 cites W2046898219 @default.
- W2973256189 cites W2048292311 @default.
- W2973256189 cites W2051755309 @default.
- W2973256189 cites W2054685711 @default.
- W2973256189 cites W2056146193 @default.
- W2973256189 cites W2064536606 @default.
- W2973256189 cites W2079945852 @default.
- W2973256189 cites W2082958780 @default.
- W2973256189 cites W2083086547 @default.
- W2973256189 cites W2084671887 @default.
- W2973256189 cites W2085424855 @default.
- W2973256189 cites W2088754913 @default.
- W2973256189 cites W2088900087 @default.
- W2973256189 cites W2092454407 @default.
- W2973256189 cites W2099026515 @default.
- W2973256189 cites W2115685960 @default.
- W2973256189 cites W2116030730 @default.
- W2973256189 cites W2117674127 @default.
- W2973256189 cites W2118402202 @default.
- W2973256189 cites W2125802564 @default.
- W2973256189 cites W2133226946 @default.
- W2973256189 cites W2133426555 @default.
- W2973256189 cites W2135936181 @default.
- W2973256189 cites W2138152051 @default.
- W2973256189 cites W2143531499 @default.
- W2973256189 cites W2147156629 @default.
- W2973256189 cites W2155044423 @default.
- W2973256189 cites W2159026586 @default.
- W2973256189 cites W2159417266 @default.
- W2973256189 cites W2159999899 @default.
- W2973256189 cites W2162660365 @default.
- W2973256189 cites W2166849813 @default.
- W2973256189 cites W220347558 @default.
- W2973256189 cites W2381661296 @default.
- W2973256189 cites W2416372007 @default.
- W2973256189 cites W2581268949 @default.
- W2973256189 cites W2588683679 @default.
- W2973256189 cites W2595085614 @default.
- W2973256189 cites W2605750225 @default.
- W2973256189 cites W2607501592 @default.
- W2973256189 cites W2615517541 @default.
- W2973256189 cites W2761961449 @default.
- W2973256189 cites W2762153312 @default.
- W2973256189 cites W2797499614 @default.
- W2973256189 doi "https://doi.org/10.1038/s41598-019-49428-y" @default.
- W2973256189 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6754424" @default.
- W2973256189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31541141" @default.
- W2973256189 hasPublicationYear "2019" @default.
- W2973256189 type Work @default.
- W2973256189 sameAs 2973256189 @default.
- W2973256189 citedByCount "18" @default.
- W2973256189 countsByYear W29732561892020 @default.
- W2973256189 countsByYear W29732561892021 @default.
- W2973256189 countsByYear W29732561892022 @default.
- W2973256189 countsByYear W29732561892023 @default.
- W2973256189 crossrefType "journal-article" @default.
- W2973256189 hasAuthorship W2973256189A5009589418 @default.
- W2973256189 hasAuthorship W2973256189A5010321945 @default.
- W2973256189 hasAuthorship W2973256189A5027859130 @default.
- W2973256189 hasAuthorship W2973256189A5044182575 @default.
- W2973256189 hasAuthorship W2973256189A5054520863 @default.
- W2973256189 hasAuthorship W2973256189A5055580140 @default.
- W2973256189 hasAuthorship W2973256189A5065405485 @default.
- W2973256189 hasAuthorship W2973256189A5089465392 @default.