FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973262824> ?p ?o ?g. }

• W2973262824 abstract "Abstract Background The molecular characterization of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) isolates is not well studied. Our goal was to investigate the molecular epidemiology of CR-hvKP strains that were isolated from a Chinese hospital. Results All clinical carbapenem-resistant K. pneumoniae (CR-KP) isolates were collected and identified from patient samples between 2014 and 2017 from a Chinese hospital. The samples were subjected to screening for CR-hvKP by string test and the detection of the aerobactin gene. CR-hvKP isolates were further confirmed through neutrophil phagocytosis and a mice lethality assay. The CR-hvKP isolates were investigated for their capsular genotyping, virulence gene profiles, and the expression of carbapenemase genes by PCR and DNA sequencing. Multilocus sequence type (MLST) and pulsed-field gel electrophoresis (PFGE) were performed to exclude the homology of these isolates. Twenty strains were identified as CR-hvKP. These strains were resistant to imipenem and several other antibiotics, however, most were susceptible to amikacin. Notably, two isolates were not susceptible to tigecycline. Capsular polysaccharide synthesis genotyping revealed that 17 of the 20 CR-hvKP strains belonged to the K2 serotype, while the others belonged to serotypes other than K1, K2, K5, K20, and K57. The strains were found to be positive for 10 types of virulence genes and a variety of these genes coexisted in the same strain. Two carbapenemase genes were identified: bla KPC-2 (13/20) and bla NDM-1 (1/20). PFGE typing revealed eight clusters comprising isolates that belonged to MLST types ST25, ST11 and ST375, respectively. PFGE cluster A was identified as the main cluster, which included 11 isolates that belong to ST25 and mainly from ICU department. Conclusions Our findings suggest that hospital-acquired infections may contribute in part to the CR-hvKP strains identified in this study. It also suggests that ST25 CR-hvKP strain has a clonal distribution in our hospital. Therefore, effective surveillance and strict infection control strategies should be implemented to prevent outbreak by CR-hvKP strains in hospitals setting." @default.
• W2973262824 created "2019-09-26" @default.
• W2973262824 creator A5019298981 @default.
• W2973262824 creator A5027835055 @default.
• W2973262824 creator A5033476436 @default.
• W2973262824 creator A5037819971 @default.
• W2973262824 creator A5049054329 @default.
• W2973262824 creator A5076397217 @default.
• W2973262824 creator A5091835329 @default.
• W2973262824 date "2019-09-18" @default.
• W2973262824 modified "2023-10-12" @default.
• W2973262824 title "Isolation and characterization of a sequence type 25 carbapenem-resistant hypervirulent Klebsiella pneumoniae from the mid-south region of China" @default.
• W2973262824 cites W1955612312 @default.
• W2973262824 cites W1992681989 @default.
• W2973262824 cites W1996213540 @default.
• W2973262824 cites W1998568933 @default.
• W2973262824 cites W2007225459 @default.
• W2973262824 cites W2020811265 @default.
• W2973262824 cites W2030584240 @default.
• W2973262824 cites W2031052487 @default.
• W2973262824 cites W2040419681 @default.
• W2973262824 cites W2059597039 @default.
• W2973262824 cites W2088527369 @default.
• W2973262824 cites W2100475906 @default.
• W2973262824 cites W2106788891 @default.
• W2973262824 cites W2110094100 @default.
• W2973262824 cites W2145111808 @default.
• W2973262824 cites W2145855467 @default.
• W2973262824 cites W2149694043 @default.
• W2973262824 cites W2154556219 @default.
• W2973262824 cites W2165082033 @default.
• W2973262824 cites W2169303192 @default.
• W2973262824 cites W2213108411 @default.
• W2973262824 cites W2462428740 @default.
• W2973262824 cites W2472516215 @default.
• W2973262824 cites W2500996975 @default.
• W2973262824 cites W2558482643 @default.
• W2973262824 cites W2584169226 @default.
• W2973262824 cites W2591867467 @default.
• W2973262824 cites W2604239844 @default.
• W2973262824 cites W2750630201 @default.
• W2973262824 cites W2770546211 @default.
• W2973262824 cites W2778095271 @default.
• W2973262824 cites W2784097207 @default.
• W2973262824 cites W2794622285 @default.
• W2973262824 cites W2800102240 @default.
• W2973262824 cites W2802901438 @default.
• W2973262824 doi "https://doi.org/10.1186/s12866-019-1593-5" @default.
• W2973262824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6749629" @default.
• W2973262824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31533609" @default.
• W2973262824 hasPublicationYear "2019" @default.
• W2973262824 type Work @default.
• W2973262824 sameAs 2973262824 @default.
• W2973262824 citedByCount "32" @default.
• W2973262824 countsByYear W29732628242019 @default.
• W2973262824 countsByYear W29732628242020 @default.
• W2973262824 countsByYear W29732628242021 @default.
• W2973262824 countsByYear W29732628242022 @default.
• W2973262824 countsByYear W29732628242023 @default.
• W2973262824 crossrefType "journal-article" @default.
• W2973262824 hasAuthorship W2973262824A5019298981 @default.
• W2973262824 hasAuthorship W2973262824A5027835055 @default.
• W2973262824 hasAuthorship W2973262824A5033476436 @default.
• W2973262824 hasAuthorship W2973262824A5037819971 @default.
• W2973262824 hasAuthorship W2973262824A5049054329 @default.
• W2973262824 hasAuthorship W2973262824A5076397217 @default.
• W2973262824 hasAuthorship W2973262824A5091835329 @default.
• W2973262824 hasBestOaLocation W29732628241 @default.
• W2973262824 hasConcept C104317684 @default.
• W2973262824 hasConcept C135763542 @default.
• W2973262824 hasConcept C159047783 @default.
• W2973262824 hasConcept C2777027569 @default.
• W2973262824 hasConcept C2777058267 @default.
• W2973262824 hasConcept C2778487981 @default.
• W2973262824 hasConcept C2778910516 @default.
• W2973262824 hasConcept C2779631663 @default.
• W2973262824 hasConcept C31467283 @default.
• W2973262824 hasConcept C42084846 @default.
• W2973262824 hasConcept C501593827 @default.
• W2973262824 hasConcept C54355233 @default.
• W2973262824 hasConcept C547475151 @default.
• W2973262824 hasConcept C60987743 @default.
• W2973262824 hasConcept C77434933 @default.
• W2973262824 hasConcept C86803240 @default.
• W2973262824 hasConcept C89423630 @default.
• W2973262824 hasConcept C94665300 @default.
• W2973262824 hasConcept C97669555 @default.
• W2973262824 hasConceptScore W2973262824C104317684 @default.
• W2973262824 hasConceptScore W2973262824C135763542 @default.
• W2973262824 hasConceptScore W2973262824C159047783 @default.
• W2973262824 hasConceptScore W2973262824C2777027569 @default.
• W2973262824 hasConceptScore W2973262824C2777058267 @default.
• W2973262824 hasConceptScore W2973262824C2778487981 @default.
• W2973262824 hasConceptScore W2973262824C2778910516 @default.
• W2973262824 hasConceptScore W2973262824C2779631663 @default.
• W2973262824 hasConceptScore W2973262824C31467283 @default.
• W2973262824 hasConceptScore W2973262824C42084846 @default.
• W2973262824 hasConceptScore W2973262824C501593827 @default.
• W2973262824 hasConceptScore W2973262824C54355233 @default.
• W2973262824 hasConceptScore W2973262824C547475151 @default.

• next