Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973288220> ?p ?o ?g. }
- W2973288220 abstract "Summary The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations. Although it is known that inhibitory synaptic strength is malleable, induction of long-term plasticity at distinct inhibitory synapses and its regulation of hippocampal network activity is not well understood. Here, we show that inhibitory synapses from parvalbumin and somatostatin expressing interneurons undergo long-term depression and potentiation respectively (PV-iLTD and SST-iLTP) during physiological activity patterns. Both forms of plasticity rely on T-type calcium channel activation to confer synapse specificity but otherwise employ distinct mechanisms. Since parvalbumin and somatostatin interneurons preferentially target perisomatic and distal dendritic regions respectively of CA1 pyramidal cells, PV-iLTD and SST-iLTP coordinate a reprioritisation of excitatory inputs from entorhinal cortex and CA3. Furthermore, circuit-level modelling reveals that PV-iLTD and SST-iLTP cooperate to stabilise place cells while facilitating representation of multiple unique environments within the hippocampal network." @default.
- W2973288220 created "2019-09-26" @default.
- W2973288220 creator A5022940492 @default.
- W2973288220 creator A5023011366 @default.
- W2973288220 creator A5039497694 @default.
- W2973288220 creator A5059209717 @default.
- W2973288220 creator A5072294078 @default.
- W2973288220 date "2019-09-24" @default.
- W2973288220 modified "2023-10-06" @default.
- W2973288220 title "Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output" @default.
- W2973288220 cites W1480770914 @default.
- W2973288220 cites W1536871616 @default.
- W2973288220 cites W1604219090 @default.
- W2973288220 cites W1845046061 @default.
- W2973288220 cites W1944255113 @default.
- W2973288220 cites W1964092556 @default.
- W2973288220 cites W1966647250 @default.
- W2973288220 cites W1971977136 @default.
- W2973288220 cites W1976070765 @default.
- W2973288220 cites W1976763493 @default.
- W2973288220 cites W1979854415 @default.
- W2973288220 cites W1990083144 @default.
- W2973288220 cites W1999328319 @default.
- W2973288220 cites W2008027377 @default.
- W2973288220 cites W2011483739 @default.
- W2973288220 cites W2013427111 @default.
- W2973288220 cites W2016405036 @default.
- W2973288220 cites W2022856399 @default.
- W2973288220 cites W2025806474 @default.
- W2973288220 cites W2029638208 @default.
- W2973288220 cites W2030159093 @default.
- W2973288220 cites W2033129564 @default.
- W2973288220 cites W2041656098 @default.
- W2973288220 cites W2044124598 @default.
- W2973288220 cites W2045927851 @default.
- W2973288220 cites W2047106437 @default.
- W2973288220 cites W2047347093 @default.
- W2973288220 cites W2047464323 @default.
- W2973288220 cites W2049517487 @default.
- W2973288220 cites W2053696585 @default.
- W2973288220 cites W2056336718 @default.
- W2973288220 cites W2061960110 @default.
- W2973288220 cites W2063144485 @default.
- W2973288220 cites W2065620757 @default.
- W2973288220 cites W2066144751 @default.
- W2973288220 cites W2067501282 @default.
- W2973288220 cites W2069164397 @default.
- W2973288220 cites W2071549768 @default.
- W2973288220 cites W2072233684 @default.
- W2973288220 cites W2083547018 @default.
- W2973288220 cites W2084079308 @default.
- W2973288220 cites W2087298647 @default.
- W2973288220 cites W2090585744 @default.
- W2973288220 cites W2097237250 @default.
- W2973288220 cites W2146263938 @default.
- W2973288220 cites W2149615516 @default.
- W2973288220 cites W2151093700 @default.
- W2973288220 cites W2161627797 @default.
- W2973288220 cites W2163233331 @default.
- W2973288220 cites W2165039060 @default.
- W2973288220 cites W2171390108 @default.
- W2973288220 cites W2171830917 @default.
- W2973288220 cites W2237700610 @default.
- W2973288220 cites W2275929617 @default.
- W2973288220 cites W2277467641 @default.
- W2973288220 cites W2286267847 @default.
- W2973288220 cites W2345447579 @default.
- W2973288220 cites W2380705552 @default.
- W2973288220 cites W2419198261 @default.
- W2973288220 cites W2536391716 @default.
- W2973288220 cites W2606468927 @default.
- W2973288220 cites W2695501819 @default.
- W2973288220 cites W2737337224 @default.
- W2973288220 cites W2751166226 @default.
- W2973288220 cites W2759536331 @default.
- W2973288220 cites W2763166029 @default.
- W2973288220 cites W2781975760 @default.
- W2973288220 cites W2790032173 @default.
- W2973288220 cites W2885684158 @default.
- W2973288220 cites W2887094843 @default.
- W2973288220 cites W2889189141 @default.
- W2973288220 cites W2897182875 @default.
- W2973288220 cites W2919932807 @default.
- W2973288220 cites W2951619011 @default.
- W2973288220 cites W2963349042 @default.
- W2973288220 cites W4245746501 @default.
- W2973288220 cites W954230352 @default.
- W2973288220 doi "https://doi.org/10.1101/774562" @default.
- W2973288220 hasPublicationYear "2019" @default.
- W2973288220 type Work @default.
- W2973288220 sameAs 2973288220 @default.
- W2973288220 citedByCount "0" @default.
- W2973288220 crossrefType "posted-content" @default.
- W2973288220 hasAuthorship W2973288220A5022940492 @default.
- W2973288220 hasAuthorship W2973288220A5023011366 @default.
- W2973288220 hasAuthorship W2973288220A5039497694 @default.
- W2973288220 hasAuthorship W2973288220A5059209717 @default.
- W2973288220 hasAuthorship W2973288220A5072294078 @default.
- W2973288220 hasBestOaLocation W29732882201 @default.
- W2973288220 hasConcept C112592302 @default.