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- W2973306056 abstract "N-Methyl-D-aspartatový (NMDA) receptor patři do skupiny glutamatových receptorů, ktere se dale děli na ionotropni a metabotropni. V CNS ma vliv na synaptickou plasticitu a rozvoj neuronalnich synapsi. Ionotropni NMDA receptory jsou aktivovany glutamatem, diky cemuž proudi pozitivně nabite ionty skrz membranu po svem koncentracnim gradientu. Nicmeně nadměrne hladiny glutamatu působi excitotoxicky diky vysokým intracelularnim hladinam Ca2+ a mohou vest k buněcne smrti neuronů pozorovane např. u neurodegenerativnich onemocněni. Antagoniste NMDA receptorů, mezi ktere patři napřiklad dizocilpin, ovlivňuji prostupnost NMDA receptoru a zamezuji tak vstupu iontů Ca2+ do buňky. Dizocilpin působi jako nekompetitivni antagonista NMDA receptoru, ma antikonvulzivni a anesteticke ucinky. Jeho terapeuticke použiti u lidi neni vhodne z důvodu výskytu cetných vedlejsich ucinků, experimentalně je vsak využivan jako farmakologicky indukovaný animalni model schizofrenie." @default.
- W2973306056 created "2019-09-26" @default.
- W2973306056 creator A5011323357 @default.
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- W2973306056 creator A5087115321 @default.
- W2973306056 date "2019-12-06" @default.
- W2973306056 modified "2023-09-23" @default.
- W2973306056 title "PHARMACOLOGICAL PROFILE OF DIZOCILPINE (MK-801) AND ITS POTENTIAL USE IN ANIMAL MODEL OF SCHIZOPHRENIA" @default.
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- W2973306056 doi "https://doi.org/10.31482/mmsl.2019.019" @default.
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