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- W2973359362 endingPage "1055" @default.
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- W2973359362 abstract "Introduction: The major cause of morbidity and mortality in patients with cystic fibrosis (CF) is lung disease. Inflammation in the CF airways occurs from a young age and contributes significantly to disease progression and shortened life expectancy.Areas covered: In this review, we discuss the key immune cells involved in airway inflammation in CF, the contribution of the intrinsic genetic defect to the CF inflammatory phenotype, and anti-inflammatory strategies designed to overcome what is a critical factor in the pathogenesis of CF lung disease. Review of the literature was carried out using the MEDLINE (from 1975 to 2018), Google Scholar and The Cochrane Library databases.Expert opinion: Therapeutic interventions specifically targeting the defective CF transmembrane conductance regulator (CFTR) protein have changed the clinical landscape and significantly improved the outlook for CF. As survival estimates for people with CF increase, long-term management has become an important focus, with an increased need for therapies targeted at specific elements of inflammation, to complement CFTR modulator therapies." @default.
- W2973359362 created "2019-09-26" @default.
- W2973359362 creator A5011260841 @default.
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- W2973359362 creator A5023945170 @default.
- W2973359362 creator A5028004559 @default.
- W2973359362 creator A5062384147 @default.
- W2973359362 date "2019-10-10" @default.
- W2973359362 modified "2023-09-30" @default.
- W2973359362 title "Targeting airway inflammation in cystic fibrosis" @default.
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