Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973377655> ?p ?o ?g. }
- W2973377655 endingPage "197762" @default.
- W2973377655 startingPage "197762" @default.
- W2973377655 abstract "To analyze the hepatitis B virus (HBV) quasi-subgenotype B3 characters and molecular evolution in Southeast Asia, 411 serum samples with HBsAg positive were collected from Xishuangbanna, China. After DNA extraction, PCR amplification and sequencing, a total of 183 HBV full-length genomes were obtained. Phylogenetic analysis showed 139 stains (76.0%) were genotype B, 41 strains were genotype C (22.4%) and 3 strains were genotype I (1.6%). Among genotype B, 34 sequences were identified as quasi-subgenotype B3. Quasi-subgenotype B3 sequences from this study and quasi-subgenotype B3 sequences from the GenBank (total of 141 complete genome sequences) were grouped into quasi-subgenotype B3 (B3, formerly B5, Chinese B6 and B7-9). Sixteen peculiar nucleotides distributed in quasi-subgenotype B3 were identified, which were differ from B1, B2, B4 and B5(formerly B6) (nt93 T, nt100C, nt355 G, nt843 T, nt861C, nt912C, nt929 T, nt930 G, nt1023 T, nt1041 T, nt2651C, nt2693 T, nt2970C, nt3054A, nt3087A and nt3171 G). Then Evolutionary dynamics analysis of HBV quasi-subgenotype B3 was performed. The mean rate of nucleotide substitution for HBV quasi-subgenotype B3 was estimated to be around 5.556-5.660 × 10-4 substitutions/site/year. Estimated time to most recent ancestor of quasi-subgenotype B3 was around the 1847-1945(95%HPD), and Yunnan strains might be the parental strains. The Bayesian sky plot showed a steady spreading of HBV quasi-genotype B3 from early of 1940s to 90 s. In summary, HBV quasi-subgenotype B3 infection is prevalent in Southeast Asia based on the current reports and still with a high prevalence rate based on the evolutionary dynamics analysis. Current vaccine and nucleotide analogues might have effective prevention and treatment for HBV quasi-subgenotype B3 based on the rare clinically relevant mutation sites included in quasi-subgenotype B3." @default.
- W2973377655 created "2019-09-26" @default.
- W2973377655 creator A5043273399 @default.
- W2973377655 creator A5044418600 @default.
- W2973377655 creator A5056924860 @default.
- W2973377655 creator A5064678562 @default.
- W2973377655 date "2019-11-01" @default.
- W2973377655 modified "2023-09-24" @default.
- W2973377655 title "Characteristics and evolutionary history of hepatitis B virus quasi-subgenotype B3 in Southeast Asia" @default.
- W2973377655 cites W1506042258 @default.
- W2973377655 cites W1532462036 @default.
- W2973377655 cites W1587072911 @default.
- W2973377655 cites W1836518043 @default.
- W2973377655 cites W1901300243 @default.
- W2973377655 cites W1903589011 @default.
- W2973377655 cites W1973271690 @default.
- W2973377655 cites W1975953151 @default.
- W2973377655 cites W1991040699 @default.
- W2973377655 cites W1994936808 @default.
- W2973377655 cites W2000870362 @default.
- W2973377655 cites W2007343420 @default.
- W2973377655 cites W2017416275 @default.
- W2973377655 cites W2020770066 @default.
- W2973377655 cites W2021149489 @default.
- W2973377655 cites W2026192891 @default.
- W2973377655 cites W2029671846 @default.
- W2973377655 cites W2031876582 @default.
- W2973377655 cites W2032161987 @default.
- W2973377655 cites W2032706525 @default.
- W2973377655 cites W2047803534 @default.
- W2973377655 cites W2071881392 @default.
- W2973377655 cites W2075510419 @default.
- W2973377655 cites W2092152428 @default.
- W2973377655 cites W2094078491 @default.
- W2973377655 cites W2099428897 @default.
- W2973377655 cites W2104387741 @default.
- W2973377655 cites W2113439848 @default.
- W2973377655 cites W2130638850 @default.
- W2973377655 cites W2132068270 @default.
- W2973377655 cites W2144375124 @default.
- W2973377655 cites W2145811893 @default.
- W2973377655 cites W2145831539 @default.
- W2973377655 cites W2145850754 @default.
- W2973377655 cites W2147363669 @default.
- W2973377655 cites W2158723472 @default.
- W2973377655 cites W2162484338 @default.
- W2973377655 cites W2442985902 @default.
- W2973377655 cites W2540877939 @default.
- W2973377655 cites W2548518295 @default.
- W2973377655 doi "https://doi.org/10.1016/j.virusres.2019.197762" @default.
- W2973377655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31541667" @default.
- W2973377655 hasPublicationYear "2019" @default.
- W2973377655 type Work @default.
- W2973377655 sameAs 2973377655 @default.
- W2973377655 citedByCount "5" @default.
- W2973377655 countsByYear W29733776552019 @default.
- W2973377655 countsByYear W29733776552022 @default.
- W2973377655 countsByYear W29733776552023 @default.
- W2973377655 crossrefType "journal-article" @default.
- W2973377655 hasAuthorship W2973377655A5043273399 @default.
- W2973377655 hasAuthorship W2973377655A5044418600 @default.
- W2973377655 hasAuthorship W2973377655A5056924860 @default.
- W2973377655 hasAuthorship W2973377655A5064678562 @default.
- W2973377655 hasConcept C104317684 @default.
- W2973377655 hasConcept C135763542 @default.
- W2973377655 hasConcept C141231307 @default.
- W2973377655 hasConcept C159047783 @default.
- W2973377655 hasConcept C193252679 @default.
- W2973377655 hasConcept C2522874641 @default.
- W2973377655 hasConcept C2777410769 @default.
- W2973377655 hasConcept C2780593183 @default.
- W2973377655 hasConcept C54355233 @default.
- W2973377655 hasConcept C79029880 @default.
- W2973377655 hasConcept C86803240 @default.
- W2973377655 hasConceptScore W2973377655C104317684 @default.
- W2973377655 hasConceptScore W2973377655C135763542 @default.
- W2973377655 hasConceptScore W2973377655C141231307 @default.
- W2973377655 hasConceptScore W2973377655C159047783 @default.
- W2973377655 hasConceptScore W2973377655C193252679 @default.
- W2973377655 hasConceptScore W2973377655C2522874641 @default.
- W2973377655 hasConceptScore W2973377655C2777410769 @default.
- W2973377655 hasConceptScore W2973377655C2780593183 @default.
- W2973377655 hasConceptScore W2973377655C54355233 @default.
- W2973377655 hasConceptScore W2973377655C79029880 @default.
- W2973377655 hasConceptScore W2973377655C86803240 @default.
- W2973377655 hasFunder F4320325440 @default.
- W2973377655 hasLocation W29733776551 @default.
- W2973377655 hasLocation W29733776552 @default.
- W2973377655 hasOpenAccess W2973377655 @default.
- W2973377655 hasPrimaryLocation W29733776551 @default.
- W2973377655 hasRelatedWork W1598303988 @default.
- W2973377655 hasRelatedWork W1977280254 @default.
- W2973377655 hasRelatedWork W1995844038 @default.
- W2973377655 hasRelatedWork W2058381089 @default.
- W2973377655 hasRelatedWork W206078874 @default.
- W2973377655 hasRelatedWork W2064248292 @default.
- W2973377655 hasRelatedWork W2085800828 @default.
- W2973377655 hasRelatedWork W2308869671 @default.