FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973416177> ?p ?o ?g. }

• W2973416177 endingPage "608" @default.
• W2973416177 startingPage "602" @default.
• W2973416177 abstract "Abstract Ceftiofur, a third‐generation cephalosporin antibiotic, is being extensively used by pet doctors in China. In the current study, the detection method was developed for ceftiofur and its metabolites, desfuroylceftiofur (DCE) and desfuroylceftiofur conjugates (DCEC), in feline plasma. Then, the pharmacokinetics studies were performed following one single intravenous and subcutaneous injection of ceftiofur sodium in cats both at 5 mg/kg body weight (BW) (calculated as pure ceftiofur). Ceftiofur, DCE, and DCEC were extracted from plasma samples, then derivatized and further quantified by high‐performance liquid chromatography. The concentrations versus time data were subjected to noncompartmental analysis to obtain the pharmacokinetics parameters. The terminal half‐life ( t 1/2λz ) was calculated as 11.29 ± 1.09 and 10.69 ± 1.31 hr following intravenous and subcutaneous injections, respectively. After intravenous treatment, the total body clearance (Cl) and volume of distribution at steady‐state ( V SS ) were determined as 14.14 ± 1.09 ml hr ‐1 kg ‐1 and 241.71 ± 22.40 ml/kg, respectively. After subcutaneous injection, the peak concentration ( C max ; 14.99 ± 2.29 μg/ml) was observed at 4.17 ± 0.41 hr, and the absorption half‐life ( t 1/2ka ) and absolute bioavailability (F) were calculated as 2.83 ± 0.46 hr and 82.95%±9.59%, respectively. The pharmacokinetic profiles of ceftiofur sodium and its related metabolites demonstrated their relatively slow, however, good absorption after subcutaneous administration, poor distribution, and slow elimination in cats. Based on the time of drug concentration above the minimum inhibitory concentration (MIC) (T>MIC) calculated in the current study, an intravenous or subcutaneous dose at 5 mg/kg BW of ceftiofur sodium once daily is predicted to be effective for treating feline bacteria with a MIC value of ≤4.0 μg/ml." @default.
• W2973416177 created "2019-09-26" @default.
• W2973416177 creator A5000075730 @default.
• W2973416177 creator A5011272018 @default.
• W2973416177 creator A5013552704 @default.
• W2973416177 creator A5032225811 @default.
• W2973416177 creator A5041993066 @default.
• W2973416177 creator A5049281977 @default.
• W2973416177 creator A5051993838 @default.
• W2973416177 creator A5083419311 @default.
• W2973416177 date "2019-09-17" @default.
• W2973416177 modified "2023-09-27" @default.
• W2973416177 title "Pharmacokinetics of ceftiofur sodium in cats following a single intravenous and subcutaneous injection" @default.
• W2973416177 cites W1583540321 @default.
• W2973416177 cites W1960640744 @default.
• W2973416177 cites W1970400998 @default.
• W2973416177 cites W2014183196 @default.
• W2973416177 cites W2019657277 @default.
• W2973416177 cites W2035247324 @default.
• W2973416177 cites W2044612307 @default.
• W2973416177 cites W2069145048 @default.
• W2973416177 cites W2079691262 @default.
• W2973416177 cites W2092721328 @default.
• W2973416177 cites W2095488178 @default.
• W2973416177 cites W2114425867 @default.
• W2973416177 cites W2122183617 @default.
• W2973416177 cites W2131171455 @default.
• W2973416177 cites W2150336584 @default.
• W2973416177 cites W2169819148 @default.
• W2973416177 cites W2322986256 @default.
• W2973416177 cites W2346694037 @default.
• W2973416177 cites W2404840038 @default.
• W2973416177 cites W2436762395 @default.
• W2973416177 cites W2502670554 @default.
• W2973416177 cites W2531460542 @default.
• W2973416177 cites W2553296209 @default.
• W2973416177 cites W2563699717 @default.
• W2973416177 cites W2565537108 @default.
• W2973416177 cites W2602657493 @default.
• W2973416177 cites W2768416121 @default.
• W2973416177 cites W2808493159 @default.
• W2973416177 cites W2810706988 @default.
• W2973416177 cites W2898740760 @default.
• W2973416177 cites W4244553104 @default.
• W2973416177 doi "https://doi.org/10.1111/jvp.12814" @default.
• W2973416177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32281146" @default.
• W2973416177 hasPublicationYear "2019" @default.
• W2973416177 type Work @default.
• W2973416177 sameAs 2973416177 @default.
• W2973416177 citedByCount "2" @default.
• W2973416177 countsByYear W29734161772020 @default.
• W2973416177 countsByYear W29734161772021 @default.
• W2973416177 crossrefType "journal-article" @default.
• W2973416177 hasAuthorship W2973416177A5000075730 @default.
• W2973416177 hasAuthorship W2973416177A5011272018 @default.
• W2973416177 hasAuthorship W2973416177A5013552704 @default.
• W2973416177 hasAuthorship W2973416177A5032225811 @default.
• W2973416177 hasAuthorship W2973416177A5041993066 @default.
• W2973416177 hasAuthorship W2973416177A5049281977 @default.
• W2973416177 hasAuthorship W2973416177A5051993838 @default.
• W2973416177 hasAuthorship W2973416177A5083419311 @default.
• W2973416177 hasConcept C112705442 @default.
• W2973416177 hasConcept C125287762 @default.
• W2973416177 hasConcept C139254425 @default.
• W2973416177 hasConcept C159985019 @default.
• W2973416177 hasConcept C181389837 @default.
• W2973416177 hasConcept C185592680 @default.
• W2973416177 hasConcept C192562407 @default.
• W2973416177 hasConcept C2780122547 @default.
• W2973416177 hasConcept C43617362 @default.
• W2973416177 hasConcept C501593827 @default.
• W2973416177 hasConcept C55493867 @default.
• W2973416177 hasConcept C64778159 @default.
• W2973416177 hasConcept C71924100 @default.
• W2973416177 hasConcept C98274493 @default.
• W2973416177 hasConceptScore W2973416177C112705442 @default.
• W2973416177 hasConceptScore W2973416177C125287762 @default.
• W2973416177 hasConceptScore W2973416177C139254425 @default.
• W2973416177 hasConceptScore W2973416177C159985019 @default.
• W2973416177 hasConceptScore W2973416177C181389837 @default.
• W2973416177 hasConceptScore W2973416177C185592680 @default.
• W2973416177 hasConceptScore W2973416177C192562407 @default.
• W2973416177 hasConceptScore W2973416177C2780122547 @default.
• W2973416177 hasConceptScore W2973416177C43617362 @default.
• W2973416177 hasConceptScore W2973416177C501593827 @default.
• W2973416177 hasConceptScore W2973416177C55493867 @default.
• W2973416177 hasConceptScore W2973416177C64778159 @default.
• W2973416177 hasConceptScore W2973416177C71924100 @default.
• W2973416177 hasConceptScore W2973416177C98274493 @default.
• W2973416177 hasFunder F4320321001 @default.
• W2973416177 hasIssue "6" @default.
• W2973416177 hasLocation W29734161771 @default.
• W2973416177 hasLocation W29734161772 @default.
• W2973416177 hasOpenAccess W2973416177 @default.
• W2973416177 hasPrimaryLocation W29734161771 @default.
• W2973416177 hasRelatedWork W2005031996 @default.
• W2973416177 hasRelatedWork W2020343058 @default.
• W2973416177 hasRelatedWork W2032585344 @default.

• next