Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973443323> ?p ?o ?g. }
- W2973443323 endingPage "116" @default.
- W2973443323 startingPage "108" @default.
- W2973443323 abstract "B cells express various inhibitory co-receptors including CD22 (also known as Siglec-2), Siglec-10 (Siglec-G in mice), CD72, LILRB (PIR-B in mice) and FcγRIIB that contain immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region and negatively regulate BCR signaling by recruiting phosphatases to the ITIMs. Some of the inhibitory B cell co-receptors suppress development of SLE. Among these, CD72 most strongly regulates SLE. CD72 recognizes Sm/RNP, a lupus self-antigen and an endogenous TLR7 ligand, as a specific ligand, and suppresses B cell response to this TLR7 ligand. This suppression may inhibit development of SLE because TLR7 is indispensable in multiple mouse SLE models. In contrast, inhibitory B cell co-receptors such as CD22 and CD72 inhibit expansion of regulatory B cells that are known to regulate development of autoimmune diseases including type 1 diabetes (T1D) and multiple sclerosis. CD72 strongly exacerbate development of T1D in NOD mice probably by limiting expansion of regulatory B cells. Thus, inhibitory B cell co-receptors especially CD72 regulates distinct autoimmune diseases either positively or negatively. As B cell depletion therapy clearly reveals crucial roles of B cells in the regulation of various autoimmune diseases, CD72 may be a novel therapeutic target for treatment of autoimmune diseases." @default.
- W2973443323 created "2019-09-26" @default.
- W2973443323 creator A5078122217 @default.
- W2973443323 date "2019-07-03" @default.
- W2973443323 modified "2023-10-16" @default.
- W2973443323 title "Inhibitory B cell co-receptors and autoimmune diseases" @default.
- W2973443323 cites W1567114372 @default.
- W2973443323 cites W1608469865 @default.
- W2973443323 cites W1638118783 @default.
- W2973443323 cites W1715124350 @default.
- W2973443323 cites W1781404721 @default.
- W2973443323 cites W1790240239 @default.
- W2973443323 cites W1896868877 @default.
- W2973443323 cites W1918941126 @default.
- W2973443323 cites W1964724870 @default.
- W2973443323 cites W1969784842 @default.
- W2973443323 cites W1978262930 @default.
- W2973443323 cites W1984198105 @default.
- W2973443323 cites W1993116843 @default.
- W2973443323 cites W1994613799 @default.
- W2973443323 cites W1999049076 @default.
- W2973443323 cites W2011444435 @default.
- W2973443323 cites W2014993261 @default.
- W2973443323 cites W2023216402 @default.
- W2973443323 cites W2025412364 @default.
- W2973443323 cites W2029182344 @default.
- W2973443323 cites W2042797177 @default.
- W2973443323 cites W2046037953 @default.
- W2973443323 cites W2052756021 @default.
- W2973443323 cites W2053283871 @default.
- W2973443323 cites W2063413550 @default.
- W2973443323 cites W2063470653 @default.
- W2973443323 cites W2064431167 @default.
- W2973443323 cites W2069545269 @default.
- W2973443323 cites W2070666617 @default.
- W2973443323 cites W2077297620 @default.
- W2973443323 cites W2088328410 @default.
- W2973443323 cites W2092331016 @default.
- W2973443323 cites W2095547255 @default.
- W2973443323 cites W2099752901 @default.
- W2973443323 cites W2103093622 @default.
- W2973443323 cites W2106211249 @default.
- W2973443323 cites W2107455390 @default.
- W2973443323 cites W2109491705 @default.
- W2973443323 cites W2110528006 @default.
- W2973443323 cites W2110711414 @default.
- W2973443323 cites W2117269042 @default.
- W2973443323 cites W2120571886 @default.
- W2973443323 cites W2130775443 @default.
- W2973443323 cites W2134106169 @default.
- W2973443323 cites W2136752250 @default.
- W2973443323 cites W2140115940 @default.
- W2973443323 cites W2143592689 @default.
- W2973443323 cites W2143642734 @default.
- W2973443323 cites W2165025975 @default.
- W2973443323 cites W2166307427 @default.
- W2973443323 cites W2170324175 @default.
- W2973443323 cites W2172208544 @default.
- W2973443323 cites W2279785978 @default.
- W2973443323 cites W2287248643 @default.
- W2973443323 cites W2494587789 @default.
- W2973443323 cites W2538447572 @default.
- W2973443323 cites W2558035065 @default.
- W2973443323 cites W256420945 @default.
- W2973443323 cites W2583676372 @default.
- W2973443323 cites W2592584994 @default.
- W2973443323 cites W2601897680 @default.
- W2973443323 cites W2782948866 @default.
- W2973443323 cites W2795875233 @default.
- W2973443323 cites W2800778103 @default.
- W2973443323 cites W2803960655 @default.
- W2973443323 cites W2809821375 @default.
- W2973443323 cites W2878282601 @default.
- W2973443323 cites W2891608559 @default.
- W2973443323 cites W2907217606 @default.
- W2973443323 cites W2913361359 @default.
- W2973443323 cites W4233145220 @default.
- W2973443323 doi "https://doi.org/10.1080/25785826.2019.1660038" @default.
- W2973443323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31532707" @default.
- W2973443323 hasPublicationYear "2019" @default.
- W2973443323 type Work @default.
- W2973443323 sameAs 2973443323 @default.
- W2973443323 citedByCount "13" @default.
- W2973443323 countsByYear W29734433232020 @default.
- W2973443323 countsByYear W29734433232021 @default.
- W2973443323 countsByYear W29734433232022 @default.
- W2973443323 countsByYear W29734433232023 @default.
- W2973443323 crossrefType "journal-article" @default.
- W2973443323 hasAuthorship W2973443323A5078122217 @default.
- W2973443323 hasBestOaLocation W29734433231 @default.
- W2973443323 hasConcept C111700020 @default.
- W2973443323 hasConcept C136449434 @default.
- W2973443323 hasConcept C157695867 @default.
- W2973443323 hasConcept C159654299 @default.
- W2973443323 hasConcept C170493617 @default.
- W2973443323 hasConcept C203014093 @default.
- W2973443323 hasConcept C2776709828 @default.
- W2973443323 hasConcept C2778453870 @default.