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- W2973462023 startingPage "1648" @default.
- W2973462023 abstract "The extinct marsupial Tasmanian tiger, or thylacine, and the eutherian gray wolf are among the most widely recognized examples of convergent evolution in mammals. Despite being distantly related, these large predators independently evolved extremely similar craniofacial morphologies, and evidence suggests that they filled similar ecological niches. Previous analyses revealed little evidence of adaptive convergence between their protein-coding genes. Thus, the genetic basis of their convergence is still unclear. Here, we identified candidate craniofacial cis -regulatory elements across vertebrates and compared their evolutionary rates in the thylacine and wolf, revealing abundant signatures of convergent positive selection. Craniofacial thylacine–wolf accelerated regions were enriched near genes involved in TGF beta (TGFB) and BMP signaling, both of which are key morphological signaling pathways with critical roles in establishing the identities and boundaries between craniofacial tissues. Similarly, enhancers of genes involved in craniofacial nerve development showed convergent selection and involvement in these pathways. Taken together, these results suggest that adaptation in cis -regulators of TGF beta and BMP signaling may provide a mechanism to explain the coevolution of developmentally and functionally integrated craniofacial structures in these species. We also found that despite major structural differences in marsupial and eutherian brains, accelerated regions in both species were common near genes with roles in brain development. Our findings support the hypothesis that, relative to protein-coding genes, positive selection on cis -regulatory elements is likely to be an essential driver of adaptive convergent evolution and may underpin thylacine–wolf phenotypic similarities." @default.
- W2973462023 created "2019-09-26" @default.
- W2973462023 creator A5021054750 @default.
- W2973462023 creator A5060317968 @default.
- W2973462023 creator A5083732158 @default.
- W2973462023 date "2019-09-18" @default.
- W2973462023 modified "2023-10-03" @default.
- W2973462023 title "Widespread <i>cis</i>-regulatory convergence between the extinct Tasmanian tiger and gray wolf" @default.
- W2973462023 cites W1743872520 @default.
- W2973462023 cites W1793785632 @default.
- W2973462023 cites W1916587464 @default.
- W2973462023 cites W1952264567 @default.
- W2973462023 cites W1968899084 @default.
- W2973462023 cites W1970245599 @default.
- W2973462023 cites W1970574657 @default.
- W2973462023 cites W1976720438 @default.
- W2973462023 cites W1976957743 @default.
- W2973462023 cites W1979594866 @default.
- W2973462023 cites W1988554495 @default.
- W2973462023 cites W1992797254 @default.
- W2973462023 cites W1999027354 @default.
- W2973462023 cites W2000611393 @default.
- W2973462023 cites W2016791091 @default.
- W2973462023 cites W2028902486 @default.
- W2973462023 cites W2033201031 @default.
- W2973462023 cites W2035465868 @default.
- W2973462023 cites W2036507321 @default.
- W2973462023 cites W2041745288 @default.
- W2973462023 cites W2045362835 @default.
- W2973462023 cites W2045946031 @default.
- W2973462023 cites W2046842005 @default.
- W2973462023 cites W2049880398 @default.
- W2973462023 cites W2054831731 @default.
- W2973462023 cites W2056927577 @default.
- W2973462023 cites W2059652560 @default.
- W2973462023 cites W2061992493 @default.
- W2973462023 cites W2063014741 @default.
- W2973462023 cites W2064978553 @default.
- W2973462023 cites W2071932292 @default.
- W2973462023 cites W2072179839 @default.
- W2973462023 cites W2074801305 @default.
- W2973462023 cites W2086802511 @default.
- W2973462023 cites W2088608383 @default.
- W2973462023 cites W2090444218 @default.
- W2973462023 cites W2091851394 @default.
- W2973462023 cites W2093704993 @default.
- W2973462023 cites W2094005099 @default.
- W2973462023 cites W2101791034 @default.
- W2973462023 cites W2102029197 @default.
- W2973462023 cites W2102659607 @default.
- W2973462023 cites W2103886275 @default.
- W2973462023 cites W2108234281 @default.
- W2973462023 cites W2110065044 @default.
- W2973462023 cites W2114611642 @default.
- W2973462023 cites W2116805444 @default.
- W2973462023 cites W2118945051 @default.
- W2973462023 cites W2122152054 @default.
- W2973462023 cites W2127774996 @default.
- W2973462023 cites W2130122556 @default.
- W2973462023 cites W2131823580 @default.
- W2973462023 cites W2134825774 @default.
- W2973462023 cites W2139947682 @default.
- W2973462023 cites W2140164060 @default.
- W2973462023 cites W2141110565 @default.
- W2973462023 cites W2145191876 @default.
- W2973462023 cites W2145410965 @default.
- W2973462023 cites W2146120203 @default.
- W2973462023 cites W2146127418 @default.
- W2973462023 cites W2146640191 @default.
- W2973462023 cites W2147822820 @default.
- W2973462023 cites W2149771342 @default.
- W2973462023 cites W2150934173 @default.
- W2973462023 cites W2151754128 @default.
- W2973462023 cites W2154077612 @default.
- W2973462023 cites W2156634381 @default.
- W2973462023 cites W2159675211 @default.
- W2973462023 cites W2162063184 @default.
- W2973462023 cites W2167726811 @default.
- W2973462023 cites W2167852161 @default.
- W2973462023 cites W2170301165 @default.
- W2973462023 cites W2176686025 @default.
- W2973462023 cites W2199523235 @default.
- W2973462023 cites W2227278846 @default.
- W2973462023 cites W2259938310 @default.
- W2973462023 cites W2274993389 @default.
- W2973462023 cites W228843169 @default.
- W2973462023 cites W2305784951 @default.
- W2973462023 cites W2320106101 @default.
- W2973462023 cites W2343938601 @default.
- W2973462023 cites W2345356016 @default.
- W2973462023 cites W2414680576 @default.
- W2973462023 cites W2537623931 @default.
- W2973462023 cites W2557493613 @default.
- W2973462023 cites W2559482520 @default.
- W2973462023 cites W2581259096 @default.
- W2973462023 cites W2603014344 @default.
- W2973462023 cites W2604739425 @default.
- W2973462023 cites W2610851752 @default.