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• W2973595704 abstract "Abstract To have epidemic potential, a pathogen must be able to spread in human populations, but of human-infective RNA viruses only a minority can do so. We investigated the evolution of human transmissibility through parallel analyses of 1755 virus genome sequences from 39 RNA virus genera. We identified 57 lineages containing human-transmissible species and estimated that at least 74% of these lineages have evolved directly from non-human viruses in other mammals or birds, a public health threat recently designated “Disease X”. Human-transmissible viruses rarely evolve from virus lineages that can infect but not transmit between humans. This result cautions against focussing surveillance and mitigation efforts narrowly on currently known human-infective virus lineages and supports calls for a better understanding of RNA virus diversity in non-human hosts." @default.
• W2973595704 created "2019-09-26" @default.
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• W2973595704 date "2019-09-18" @default.
• W2973595704 modified "2023-09-26" @default.
• W2973595704 title "Evolutionary origins of epidemic potential among human RNA viruses" @default.
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• W2973595704 doi "https://doi.org/10.1101/771394" @default.
• W2973595704 hasPublicationYear "2019" @default.
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