Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973642758> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2973642758 endingPage "8538" @default.
- W2973642758 startingPage "8529" @default.
- W2973642758 abstract "Assessing the efficacy of anticancer agents in animal models remains a necessary step in the development of new treatment options and plays an important role in their optimization and comparison. Often, however, interpretation of the results is flawed by excessive trust in scores traditionally handed down, but whose origin and limitations have been lost. Here I examine the theories and assumptions underlying the most common rating scales, suggesting improvements to the old scores and proposing the adoption of multi-parameter analysis and interpretation of the results, considering different time-windows. I examined case examples of different scenarios of antiproliferative effects induced by treatment, demonstrating that common scores fail to distinguish between completely different responses to treatment or, in other circumstances, indicate a different outcome when the response is the same. I found that a combination of parameters, including the percent tumor growth between the start and end of treatment, the relative tumor burden at nadir and the absolute growth delay, may distinguish among the different cases and support a correct interpretation of the antitumor response. All these parameters can be derived from individual tumor growth curves in a simple way, without any change to common experimental procedures." @default.
- W2973642758 created "2019-09-26" @default.
- W2973642758 creator A5080096851 @default.
- W2973642758 date "2019-09-01" @default.
- W2973642758 modified "2023-10-18" @default.
- W2973642758 title "<p>Beyond The T/C Ratio: Old And New Anticancer Activity Scores In Vivo</p>" @default.
- W2973642758 cites W1510803587 @default.
- W2973642758 cites W1568817023 @default.
- W2973642758 cites W1571073982 @default.
- W2973642758 cites W1577378579 @default.
- W2973642758 cites W1907962006 @default.
- W2973642758 cites W1982367716 @default.
- W2973642758 cites W1985301080 @default.
- W2973642758 cites W2008401436 @default.
- W2973642758 cites W2041969498 @default.
- W2973642758 cites W2076293226 @default.
- W2973642758 cites W2081537733 @default.
- W2973642758 cites W2087312216 @default.
- W2973642758 cites W2097132502 @default.
- W2973642758 cites W2116780606 @default.
- W2973642758 cites W2126953820 @default.
- W2973642758 cites W2129297473 @default.
- W2973642758 cites W2174629180 @default.
- W2973642758 cites W2289550863 @default.
- W2973642758 cites W2410007300 @default.
- W2973642758 cites W2416068842 @default.
- W2973642758 cites W2758262796 @default.
- W2973642758 cites W2800254125 @default.
- W2973642758 doi "https://doi.org/10.2147/cmar.s215729" @default.
- W2973642758 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6756833" @default.
- W2973642758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31572007" @default.
- W2973642758 hasPublicationYear "2019" @default.
- W2973642758 type Work @default.
- W2973642758 sameAs 2973642758 @default.
- W2973642758 citedByCount "5" @default.
- W2973642758 countsByYear W29736427582021 @default.
- W2973642758 countsByYear W29736427582022 @default.
- W2973642758 countsByYear W29736427582023 @default.
- W2973642758 crossrefType "journal-article" @default.
- W2973642758 hasAuthorship W2973642758A5080096851 @default.
- W2973642758 hasBestOaLocation W29736427581 @default.
- W2973642758 hasConcept C126322002 @default.
- W2973642758 hasConcept C143998085 @default.
- W2973642758 hasConcept C149782125 @default.
- W2973642758 hasConcept C150903083 @default.
- W2973642758 hasConcept C199360897 @default.
- W2973642758 hasConcept C207001950 @default.
- W2973642758 hasConcept C33923547 @default.
- W2973642758 hasConcept C41008148 @default.
- W2973642758 hasConcept C527412718 @default.
- W2973642758 hasConcept C71924100 @default.
- W2973642758 hasConcept C86803240 @default.
- W2973642758 hasConcept C98274493 @default.
- W2973642758 hasConceptScore W2973642758C126322002 @default.
- W2973642758 hasConceptScore W2973642758C143998085 @default.
- W2973642758 hasConceptScore W2973642758C149782125 @default.
- W2973642758 hasConceptScore W2973642758C150903083 @default.
- W2973642758 hasConceptScore W2973642758C199360897 @default.
- W2973642758 hasConceptScore W2973642758C207001950 @default.
- W2973642758 hasConceptScore W2973642758C33923547 @default.
- W2973642758 hasConceptScore W2973642758C41008148 @default.
- W2973642758 hasConceptScore W2973642758C527412718 @default.
- W2973642758 hasConceptScore W2973642758C71924100 @default.
- W2973642758 hasConceptScore W2973642758C86803240 @default.
- W2973642758 hasConceptScore W2973642758C98274493 @default.
- W2973642758 hasLocation W29736427581 @default.
- W2973642758 hasLocation W29736427582 @default.
- W2973642758 hasLocation W29736427583 @default.
- W2973642758 hasLocation W29736427584 @default.
- W2973642758 hasOpenAccess W2973642758 @default.
- W2973642758 hasPrimaryLocation W29736427581 @default.
- W2973642758 hasRelatedWork W1990414540 @default.
- W2973642758 hasRelatedWork W1990453785 @default.
- W2973642758 hasRelatedWork W2004556784 @default.
- W2973642758 hasRelatedWork W2079763637 @default.
- W2973642758 hasRelatedWork W2468184599 @default.
- W2973642758 hasRelatedWork W2582907174 @default.
- W2973642758 hasRelatedWork W2748952813 @default.
- W2973642758 hasRelatedWork W2886928388 @default.
- W2973642758 hasRelatedWork W2899084033 @default.
- W2973642758 hasRelatedWork W4206587034 @default.
- W2973642758 hasVolume "Volume 11" @default.
- W2973642758 isParatext "false" @default.
- W2973642758 isRetracted "false" @default.
- W2973642758 magId "2973642758" @default.
- W2973642758 workType "article" @default.