FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973643921> ?p ?o ?g. }

• W2973643921 abstract "Bladder cancer (BC) is one of the most common malignant tumors in males globally. Its progression imposes a heavy burden on patients; however, the expression profile of circular (circ)RNAs in BC progression remains unclear. This study explored changes in circRNA expression during BC progression by sequencing different grade BC samples and normal controls to reveal the circRNA expression profiles of different BC grades. Gene Ontology (GO) and Kyoto Encyclopedia of Gens and Genomes (KEGG) pathway analyses, and protein‑protein interaction network construction were used to predict pathways that the differentially expressed circRNAs may participate in. circRNA expression levels were detected using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and dual‑luciferase reporter assays were used to investigate the interactions between circRNA and microRNA (miR). Cell Counting Kit‑8 and Transwell assays were also performed to detect cell proliferation, migration, and invasion. In total, 244 circRNAs were found to be differentially expressed in high‑grade BC compared to low‑grade BC, whilst 316 dysregulated circRNAs were detected in high‑grade BC compared with normal urothelium. Furthermore, 42 circRNAs overlapped between the two groups, seven of which were randomly selected and detected by RT‑qPCR to validate the sequencing results. GO analysis and KEGG pathway analyses revealed that the differentially expressed circRNAs may participate in BC via 'GTPase activity regulation', 'cell junction', and 'focal adhesion' pathways. Of note, we proposed that a novel circRNA in BC progression, hsa_circ_0137606, could suppress BC proliferation and metastasis by sponging miR‑1231. Through bioinformatics analysis, we predicted that PH domain and leucine rich repeat protein phosphatase 2 could be a target of the hsa_circ_0137606/miR‑1231 axis in BC progression. Using high‑throughput sequencing, this study revealed the circRNA expression profiles of different grades of BC and proposed that the novel circRNA, hsa_circ_0137606, suppresses BC proliferation and metastasis by sponging miR‑1231. Our findings may provide novel insight into potential therapeutic targets for treating BC." @default.
• W2973643921 created "2019-09-26" @default.
• W2973643921 creator A5013694736 @default.
• W2973643921 creator A5014789701 @default.
• W2973643921 creator A5019055948 @default.
• W2973643921 creator A5030449893 @default.
• W2973643921 creator A5040985281 @default.
• W2973643921 creator A5068996081 @default.
• W2973643921 creator A5070793235 @default.
• W2973643921 creator A5079126766 @default.
• W2973643921 date "2019-09-17" @default.
• W2973643921 modified "2023-10-13" @default.
• W2973643921 title "Comprehensive circular RNA profiling reveals the�regulatory role of the hsa_circ_0137606/miR‑1231 pathway in bladder cancer progression" @default.
• W2973643921 cites W1989141974 @default.
• W2973643921 cites W1991401661 @default.
• W2973643921 cites W2017919052 @default.
• W2973643921 cites W2029583475 @default.
• W2973643921 cites W2035618305 @default.
• W2973643921 cites W2055920203 @default.
• W2973643921 cites W2058835062 @default.
• W2973643921 cites W2064165694 @default.
• W2973643921 cites W2107277218 @default.
• W2973643921 cites W2116537347 @default.
• W2973643921 cites W2119238187 @default.
• W2973643921 cites W2119352376 @default.
• W2973643921 cites W2129189579 @default.
• W2973643921 cites W2169423074 @default.
• W2973643921 cites W2192080449 @default.
• W2973643921 cites W2272984102 @default.
• W2973643921 cites W2346058091 @default.
• W2973643921 cites W2473162054 @default.
• W2973643921 cites W2511152819 @default.
• W2973643921 cites W2550294854 @default.
• W2973643921 cites W2586427318 @default.
• W2973643921 cites W2587954422 @default.
• W2973643921 cites W2593581914 @default.
• W2973643921 cites W2609464379 @default.
• W2973643921 cites W2616072553 @default.
• W2973643921 cites W2621692635 @default.
• W2973643921 cites W2742872127 @default.
• W2973643921 cites W2764294957 @default.
• W2973643921 cites W2767546566 @default.
• W2973643921 cites W2767999015 @default.
• W2973643921 cites W2768927286 @default.
• W2973643921 cites W2774702547 @default.
• W2973643921 cites W2789403589 @default.
• W2973643921 cites W2803249602 @default.
• W2973643921 cites W2883062882 @default.
• W2973643921 cites W2883475115 @default.
• W2973643921 cites W2883894274 @default.
• W2973643921 cites W2892569486 @default.
• W2973643921 cites W2895298348 @default.
• W2973643921 cites W2896620973 @default.
• W2973643921 cites W2897904531 @default.
• W2973643921 cites W2897972067 @default.
• W2973643921 cites W2902302216 @default.
• W2973643921 cites W2911472947 @default.
• W2973643921 cites W2912017471 @default.
• W2973643921 cites W2916328247 @default.
• W2973643921 cites W2944606734 @default.
• W2973643921 cites W2946915114 @default.
• W2973643921 cites W2962699208 @default.
• W2973643921 cites W2963503833 @default.
• W2973643921 cites W4211115520 @default.
• W2973643921 doi "https://doi.org/10.3892/ijmm.2019.4340" @default.
• W2973643921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6777690" @default.
• W2973643921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31545480" @default.
• W2973643921 hasPublicationYear "2019" @default.
• W2973643921 type Work @default.
• W2973643921 sameAs 2973643921 @default.
• W2973643921 citedByCount "6" @default.
• W2973643921 countsByYear W29736439212020 @default.
• W2973643921 countsByYear W29736439212021 @default.
• W2973643921 countsByYear W29736439212022 @default.
• W2973643921 crossrefType "journal-article" @default.
• W2973643921 hasAuthorship W2973643921A5013694736 @default.
• W2973643921 hasAuthorship W2973643921A5014789701 @default.
• W2973643921 hasAuthorship W2973643921A5019055948 @default.
• W2973643921 hasAuthorship W2973643921A5030449893 @default.
• W2973643921 hasAuthorship W2973643921A5040985281 @default.
• W2973643921 hasAuthorship W2973643921A5068996081 @default.
• W2973643921 hasAuthorship W2973643921A5070793235 @default.
• W2973643921 hasAuthorship W2973643921A5079126766 @default.
• W2973643921 hasBestOaLocation W29736439211 @default.
• W2973643921 hasConcept C104317684 @default.
• W2973643921 hasConcept C121608353 @default.
• W2973643921 hasConcept C145059251 @default.
• W2973643921 hasConcept C150194340 @default.
• W2973643921 hasConcept C152724338 @default.
• W2973643921 hasConcept C153911025 @default.
• W2973643921 hasConcept C162317418 @default.
• W2973643921 hasConcept C2775893923 @default.
• W2973643921 hasConcept C2779256057 @default.
• W2973643921 hasConcept C2780352672 @default.
• W2973643921 hasConcept C2781018059 @default.
• W2973643921 hasConcept C29537977 @default.
• W2973643921 hasConcept C502942594 @default.
• W2973643921 hasConcept C54355233 @default.
• W2973643921 hasConcept C555283112 @default.
• W2973643921 hasConcept C62112901 @default.

• next