Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973692726> ?p ?o ?g. }
- W2973692726 endingPage "127086" @default.
- W2973692726 startingPage "127086" @default.
- W2973692726 abstract "The impact of pharmaceutical co-crystallization with pyromellitic dianhydride (PMDA) on the aqueous solubility of the poorly water-soluble drug Berberine (Bb+), an isoquinoline alkaloid has been investigated. The design of multicomponent solids (especially different stoichiomorphs with same coformer) using principles of crystal engineering was undertaken to achieve salt/ionic cocrystal hydrate of Bb+ with PMDA [which converts into pyromellitic acid (PMA)/pyromellitic dicarboxylate (PMA2−) during liquid-assisted grinding]. Four multicomponent stoichiomorphs, namely, two salts (1Bb+:0.5PMA2−, 1Bb+:0.5PMA2−:0.5PMA), one salt polymorph (1Bb+:0.5PMA2−:0.5PMA), and one ionic cocrystal hydrate (2Bb+:1PMA:2Cl-:2H2O), were successfully obtained from liquid-assisted grinding followed by crystallization in different solvents. The aqueous solubility of the drug, its corresponding salts and hydrate were determined in phosphate buffer (pH = 7) at 25 °C using UV–vis absorption spectroscopy experiments, and it was found that the co-crystals exhibit much reduced water solubility in comparison to its parent drug." @default.
- W2973692726 created "2019-09-26" @default.
- W2973692726 creator A5024574823 @default.
- W2973692726 creator A5048882136 @default.
- W2973692726 creator A5055445932 @default.
- W2973692726 creator A5076709103 @default.
- W2973692726 date "2020-01-01" @default.
- W2973692726 modified "2023-10-17" @default.
- W2973692726 title "Assessing the impact on aqueous solubility of berberine chloride via co-crystallization with different stoichiometric ratios of pyromellitic dianhydride" @default.
- W2973692726 cites W1910406007 @default.
- W2973692726 cites W1911902119 @default.
- W2973692726 cites W1951885505 @default.
- W2973692726 cites W1972493784 @default.
- W2973692726 cites W1974520031 @default.
- W2973692726 cites W1976555953 @default.
- W2973692726 cites W1976968874 @default.
- W2973692726 cites W1978542730 @default.
- W2973692726 cites W1978633893 @default.
- W2973692726 cites W1990170643 @default.
- W2973692726 cites W2008313230 @default.
- W2973692726 cites W2012488984 @default.
- W2973692726 cites W2013176211 @default.
- W2973692726 cites W2021720051 @default.
- W2973692726 cites W2030841140 @default.
- W2973692726 cites W2034678442 @default.
- W2973692726 cites W2049881395 @default.
- W2973692726 cites W2052193587 @default.
- W2973692726 cites W2067294686 @default.
- W2973692726 cites W2083046045 @default.
- W2973692726 cites W2085105898 @default.
- W2973692726 cites W2086945873 @default.
- W2973692726 cites W2122655172 @default.
- W2973692726 cites W2129582474 @default.
- W2973692726 cites W2145538332 @default.
- W2973692726 cites W2167713409 @default.
- W2973692726 cites W2335172167 @default.
- W2973692726 cites W2593523402 @default.
- W2973692726 cites W2731568958 @default.
- W2973692726 cites W2789618332 @default.
- W2973692726 cites W2894402667 @default.
- W2973692726 cites W2901226322 @default.
- W2973692726 cites W4231572371 @default.
- W2973692726 cites W4376542677 @default.
- W2973692726 doi "https://doi.org/10.1016/j.molstruc.2019.127086" @default.
- W2973692726 hasPublicationYear "2020" @default.
- W2973692726 type Work @default.
- W2973692726 sameAs 2973692726 @default.
- W2973692726 citedByCount "11" @default.
- W2973692726 countsByYear W29736927262020 @default.
- W2973692726 countsByYear W29736927262021 @default.
- W2973692726 countsByYear W29736927262022 @default.
- W2973692726 countsByYear W29736927262023 @default.
- W2973692726 crossrefType "journal-article" @default.
- W2973692726 hasAuthorship W2973692726A5024574823 @default.
- W2973692726 hasAuthorship W2973692726A5048882136 @default.
- W2973692726 hasAuthorship W2973692726A5055445932 @default.
- W2973692726 hasAuthorship W2973692726A5076709103 @default.
- W2973692726 hasConcept C100687433 @default.
- W2973692726 hasConcept C112887158 @default.
- W2973692726 hasConcept C13965031 @default.
- W2973692726 hasConcept C155574463 @default.
- W2973692726 hasConcept C178790620 @default.
- W2973692726 hasConcept C179104552 @default.
- W2973692726 hasConcept C184651966 @default.
- W2973692726 hasConcept C185592680 @default.
- W2973692726 hasConcept C203036418 @default.
- W2973692726 hasConcept C2776371256 @default.
- W2973692726 hasConcept C2778093655 @default.
- W2973692726 hasConcept C2779227376 @default.
- W2973692726 hasConcept C2780965675 @default.
- W2973692726 hasConcept C2781060337 @default.
- W2973692726 hasConcept C32909587 @default.
- W2973692726 hasConcept C88380143 @default.
- W2973692726 hasConceptScore W2973692726C100687433 @default.
- W2973692726 hasConceptScore W2973692726C112887158 @default.
- W2973692726 hasConceptScore W2973692726C13965031 @default.
- W2973692726 hasConceptScore W2973692726C155574463 @default.
- W2973692726 hasConceptScore W2973692726C178790620 @default.
- W2973692726 hasConceptScore W2973692726C179104552 @default.
- W2973692726 hasConceptScore W2973692726C184651966 @default.
- W2973692726 hasConceptScore W2973692726C185592680 @default.
- W2973692726 hasConceptScore W2973692726C203036418 @default.
- W2973692726 hasConceptScore W2973692726C2776371256 @default.
- W2973692726 hasConceptScore W2973692726C2778093655 @default.
- W2973692726 hasConceptScore W2973692726C2779227376 @default.
- W2973692726 hasConceptScore W2973692726C2780965675 @default.
- W2973692726 hasConceptScore W2973692726C2781060337 @default.
- W2973692726 hasConceptScore W2973692726C32909587 @default.
- W2973692726 hasConceptScore W2973692726C88380143 @default.
- W2973692726 hasFunder F4320334771 @default.
- W2973692726 hasLocation W29736927261 @default.
- W2973692726 hasOpenAccess W2973692726 @default.
- W2973692726 hasPrimaryLocation W29736927261 @default.
- W2973692726 hasRelatedWork W2013568325 @default.
- W2973692726 hasRelatedWork W2028676228 @default.
- W2973692726 hasRelatedWork W2047086033 @default.
- W2973692726 hasRelatedWork W2060007400 @default.
- W2973692726 hasRelatedWork W2761804702 @default.