Matches in SemOpenAlex for { <https://semopenalex.org/work/W2973696834> ?p ?o ?g. }
- W2973696834 abstract "The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range interaction, recurrent local connectivity and the modularity in neuronal networks. We investigated how this mesoscale architecture develops by interaction of neurite outgrowth, cell migration and activity in cultured networks of rat cortical neurons and show that simple rules can explain variations of network modularity. In contrast to theoretical studies on activity-dependent outgrowth but consistent with predictions for modular networks, spontaneous activity and the rate of synchronized bursts increased with clustering, whereas peak firing rates in bursts increased in highly interconnected homogeneous networks. As Ca2+ influx increased exponentially with increasing network recruitment during bursts, its modulation was highly correlated to peak firing rates. During network maturation, long-term estimates of Ca2+ influx showed convergence, even for highly different mesoscale architectures, neurite extent, connectivity, modularity and average activity levels, indicating homeostatic regulation towards a common set-point of Ca2+ influx." @default.
- W2973696834 created "2019-09-26" @default.
- W2973696834 creator A5006221301 @default.
- W2973696834 creator A5089848704 @default.
- W2973696834 date "2019-09-17" @default.
- W2973696834 modified "2023-09-27" @default.
- W2973696834 title "Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth" @default.
- W2973696834 cites W13189579 @default.
- W2973696834 cites W1480873606 @default.
- W2973696834 cites W1498691783 @default.
- W2973696834 cites W1515500856 @default.
- W2973696834 cites W1521404049 @default.
- W2973696834 cites W1529448825 @default.
- W2973696834 cites W1532724981 @default.
- W2973696834 cites W1553648336 @default.
- W2973696834 cites W1565722988 @default.
- W2973696834 cites W1599277155 @default.
- W2973696834 cites W1604333472 @default.
- W2973696834 cites W1821468701 @default.
- W2973696834 cites W1867894663 @default.
- W2973696834 cites W1885870414 @default.
- W2973696834 cites W1929828037 @default.
- W2973696834 cites W1946158946 @default.
- W2973696834 cites W1976054166 @default.
- W2973696834 cites W1981195606 @default.
- W2973696834 cites W1981588862 @default.
- W2973696834 cites W1985169302 @default.
- W2973696834 cites W1985232764 @default.
- W2973696834 cites W1990853579 @default.
- W2973696834 cites W1993899334 @default.
- W2973696834 cites W1994117161 @default.
- W2973696834 cites W1997551335 @default.
- W2973696834 cites W2001073277 @default.
- W2973696834 cites W2001963062 @default.
- W2973696834 cites W2003216601 @default.
- W2973696834 cites W2007897892 @default.
- W2973696834 cites W2012661701 @default.
- W2973696834 cites W2014491054 @default.
- W2973696834 cites W2014928828 @default.
- W2973696834 cites W2015195822 @default.
- W2973696834 cites W2015426350 @default.
- W2973696834 cites W2018127946 @default.
- W2973696834 cites W2021796006 @default.
- W2973696834 cites W2023175942 @default.
- W2973696834 cites W2026258429 @default.
- W2973696834 cites W2030914859 @default.
- W2973696834 cites W2037902675 @default.
- W2973696834 cites W2043737720 @default.
- W2973696834 cites W2044312508 @default.
- W2973696834 cites W2049763161 @default.
- W2973696834 cites W2051013962 @default.
- W2973696834 cites W2053457382 @default.
- W2973696834 cites W2053978255 @default.
- W2973696834 cites W2057084985 @default.
- W2973696834 cites W2057381986 @default.
- W2973696834 cites W2059743066 @default.
- W2973696834 cites W2060161122 @default.
- W2973696834 cites W2065515412 @default.
- W2973696834 cites W2066492342 @default.
- W2973696834 cites W2066508276 @default.
- W2973696834 cites W2067572306 @default.
- W2973696834 cites W2069751701 @default.
- W2973696834 cites W2070188676 @default.
- W2973696834 cites W2072363424 @default.
- W2973696834 cites W2074083222 @default.
- W2973696834 cites W2079779004 @default.
- W2973696834 cites W2082369243 @default.
- W2973696834 cites W2084722042 @default.
- W2973696834 cites W2086174087 @default.
- W2973696834 cites W2090094794 @default.
- W2973696834 cites W2091741164 @default.
- W2973696834 cites W2096827445 @default.
- W2973696834 cites W2099540110 @default.
- W2973696834 cites W2103744641 @default.
- W2973696834 cites W2103934527 @default.
- W2973696834 cites W2106545408 @default.
- W2973696834 cites W2106768378 @default.
- W2973696834 cites W2109807917 @default.
- W2973696834 cites W2112697051 @default.
- W2973696834 cites W2114079854 @default.
- W2973696834 cites W2122955029 @default.
- W2973696834 cites W2125199559 @default.
- W2973696834 cites W2131681506 @default.
- W2973696834 cites W2141005335 @default.
- W2973696834 cites W2153919162 @default.
- W2973696834 cites W2155332440 @default.
- W2973696834 cites W2156728993 @default.
- W2973696834 cites W2160913788 @default.
- W2973696834 cites W2161036636 @default.
- W2973696834 cites W2165541514 @default.
- W2973696834 cites W2167822639 @default.
- W2973696834 cites W2396075472 @default.
- W2973696834 cites W2490261221 @default.
- W2973696834 cites W2520025142 @default.
- W2973696834 cites W2533953219 @default.
- W2973696834 cites W2596420846 @default.
- W2973696834 cites W2604467167 @default.
- W2973696834 cites W2616404764 @default.
- W2973696834 cites W2885451615 @default.
- W2973696834 cites W2885808274 @default.